Advanced SearchSearch Tips
A study of relationship between stomach cancer and selenoproteins in Korean human blood serum
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Analytical Science and Technology
  • Volume 28, Issue 6,  2015, pp.417-424
  • Publisher : The Korean Society of Analytical Science
  • DOI : 10.5806/AST.2015.28.6.417
 Title & Authors
A study of relationship between stomach cancer and selenoproteins in Korean human blood serum
Park, Myungsun; Pak, Yong-Nam;
  PDF(new window)
In this study, the relationship between selenoprotein concentrations in blood and stomach cancer have been searched for Korean. The concentration of each selenoprotein in blood serum was analyzed and the correlation between the concentration and stomach cancer was studied to find a potential for using Selenium as a biomarker. In concentration determination, a simple calibration curve method was used with the monitoring of m/z 78 without the use of solid phase extraction. This is a lot more simple than the method using SPE with post column isotope dilution. The result obtained from the analysis of CRM BCR-637, 72.20±3.35 ng·g−1, showed similar value of reference value (81±7 ng·g−1). The total concentration of Se for the controlled group, cardiovascular patients group, was 105.70±21.20 ng·g−1. This value was the same as normal healthy person reported earlier. Each selenoprotein concentration of GPx, SelP and SeAlb was 26.12±7.84, 65.15±14.50, 14.43±6.99 ng·g−1, respectively. The distribution of each selenoprotein was 24.7%, 61.6%, and 13.7%, which was similar to the normal person. The result of stomach cancer patients, the total concentration of Se was 76.11±28.12 ng·g−1 and each concentration of GPx, SelP and SeAlb was 15.41±9.01, 50.83±17.91, and 9.87±5.21 ng·g−1, respectively. The total and each selenoprotein concentration level showed significant decrease for the stomach cancer patients. The level of decrease was 41.0% for GPx, 22.0% for SelP, and 31.6% for SeAlb. However, the distribution of each selenoprotein was not much different. Either total Selenium or each selenoprotein could be used as a possible index for the diagnosis of cancer. However, in age group study, it is shown that young age group (30's-40's) did not show much difference.
stomach cancer;selenoproteins;Korean blood serum;AF HPLC-ICP/MS;GPx;SelP;SeAlb;
 Cited by
J. T. Daegen, M. A. Beilstein and P. D. Whanger, J. Inorg. Biochem., 41, 261-271 (1991). crossref(new window)

H. Koyama, K. Omura, A. Ejima, Y. Kasanuma, C. Watanabe and H. Satoh, Anal. Biochem., 267, 84-91 (1999). crossref(new window)

L. H. Duntas, Thyroid, 16(5), 455-460 (2006). crossref(new window)

M. H. Borawska, K. Socha, B. Lazarcxyk, E. Czyzewska, R. Markiewicz and B. Darewicz, Nutr. Cancer, 61(5), 629-633 (2009). crossref(new window)

W. C. Hawkes and Z. Alkan, Biol. Trace Elem. Res., 134, 235-251 (2010). crossref(new window)

P. Jitaru, H. Goenaga-Infante, S. Vaslin-Reimann and P. Fisicaro, Anal. Chim. Acta, 657, 100-107 (2010). crossref(new window)

B. Mukherjee, M. Basu and M. Chatterjee, Eur. J. Cancer. Prev., 10, 347-355 (2001). crossref(new window)

B. Hollenbach, N. G. Morgenthaler, J. Struck, C. Alonso, A. Bergmann and J. Kohrle, J. Trace Elem. Med. Biol., 22, 24-32 (2008). crossref(new window)

C. D. Davis, P. A. Tsuji and J. Milner, Annu. Rev. Nutr., 32, 73-95 (2012). crossref(new window)

U. Schweizer, F. Streckfuss, B. A. Pelt, P. Carlson, D. L. Hatfield and J. Kohrle, Biochem J., 386, 221-226 (2005). crossref(new window)

Food and Nutrition Board, Institute of Medicine, Dietary reference intakes for vitamin C, vitamin E, Selenium, and Carotenoids. Washington DC, 2000.

H. Meyer, B. Hollenbach, C. Stephan, T. S. Endermann, N. Morgenthaler, H. Cammann, J. Kohrle, K. Jung and L. Schomburg, AACR, 1158, 1055-9965 (2009).

H. Meyer, T. Endermann, C. Stephan, M. Stoedter, T. Behrends, I. Wolff, K. Jung and L. Schomburg, PLoS ONE, 7(10), e46644 (2012). crossref(new window)

B. A. Muzembo, N. Dumavibhat, N. R.r Ngatu, M. Eitoku, R. Hirota, S. Kondo, Y. Deguchi, Y. Saito, K. Takahashi and N. Suganuma, J. Trace Elem. Med. Biol., 27, 40-44, (2013). crossref(new window)

M. Roman, P. Jitaru, M. Agostini, G. Cozzi, S. Pucciarelli, D. Nitti and C. Bedin, Microch. J., 105, 124-132 (2012). crossref(new window)

M. Roman, P. Jitarub and C. Barbante, Metallomics, 6, 25-54 (2014). crossref(new window)

J. Ahn, H. Kwon and Y. Pak, Anal. Sci. Tech., 27(2), 92-99 (2014). crossref(new window)

J. Jeong, J. Lee and Y. N. Pak, Bull. Kor. Chem. Soc. 34(12), 3817-3824 (2013). crossref(new window)

H. Y. Jang, H. Min, J. Lee and Y. N. Pak, Anal. Sci. Tech., 26(3), 182-189 (2013). crossref(new window)

S. H. Song, K. Song, S. Lee and C. Kim, Kor. J. Urol., 47, 150-153 (2006). crossref(new window)

H. T. Doo, ‘The relationships between serum selenium level and papillary thyroid carcinoma in Korean’ M. S. Thesis, Ulsan University (2012).