JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Outpatient Antibiotic Prescription Patterns for Respiratory Tract Infections of Infants
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Health Policy and Management
  • Volume 25, Issue 4,  2015, pp.323-332
  • Publisher : The Korean Society of Health Policy and Administration
  • DOI : 10.4332/KJHPA.2015.25.4.323
 Title & Authors
Outpatient Antibiotic Prescription Patterns for Respiratory Tract Infections of Infants
Kim, Yejee; Lee, Suehyung; Park, Sylvia; Na, Hyen Oh; Tchoe, Byongho;
  PDF(new window)
 Abstract
Background: Antibiotic resistance has been becoming serious challenge to human beings. Overuse of antibiotics, especially, for infants is concerned, but studies are very few for the prescribing pattern of antibiotic use for infants. This study analyzes prescribing patterns of antibiotics in outpatients of preschool children with acute respiratory tract infections in South Korea. Methods: Data are used from 2011 Health Insurance Review & Assessment Services-pediatric patients sample. Inclusion criteria is outpatient children (0 to 5 years) with top five frequent diseases. Prescription rates are analyzed by types of disease, provider, specialty, region, and ages. Binary or multinomial logit models are used to analyze determinants of providers' prescription pattern. Results: The main findings are as follows. First, distributions of prescription rates are shown as L-shape or M-shape depending on the types of disease. Second, the prescription variation is so large among providers, where providers are polarized as a group with low prescription rates and the other group with high prescription rates, though the shapes are shown diversified across types of disease. Third, prescription rates appear to be lower in pediatrics and higher in ENT (ear-nose-throat). Fourth, broad spectrum antibiotics are widely used among children. Finally, the logit analysis shows similar results with descriptive statistics, but partly different results across types of disease. Conclusion: Antibiotics for respiratory tract infections of infants are used excessively with a large variation among providers, and especially broad spectrum antibiotics are used. The prescription guideline for antibiotics should be provided for each specific disease to reduce antibiotic resistance in the future.
 Keywords
Antibiotics;Prescription pattern;Respiratory disease;Infant;Logit analysis;
 Language
Korean
 Cited by
 References
1.
Pichichero ME, Green JL, Francis AB, Marsocci SM, Murphy ML. Outcomes after judicious antibiotic use for respiratory tract infections seen in a private pediatric practice. Pediatrics 2000;105(4 Pt 1):753-759. DOI: http://dx.doi.org/10.1542/peds.105.4.753. crossref(new window)

2.
Spurling GK, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev 2007;(3):CD004417. DOI: http://dx.doi.org/10.1002/14651858.CD004417.pub3. crossref(new window)

3.
Fahey T, Stocks N, Thomas T. Systematic review of the treatment of upper respiratory tract infection. Arch Dis Child 1998;79(3):225-230. DOI: http://dx.doi.org/10.1136/adc.79.3.225. crossref(new window)

4.
Kim SC, Kim YR, Hwang JY, Chang HW, Nam DH. Outpatient prescription pattern of anti-inflammatory drugs by pediatricians and ENT physicians in Ulsan City. Korean J Clin Pharm 2010;20(3):203-212.

5.
Park KD. Variation of prescription patterns for acute respiratory infection patients [dissertation]. Seoul: Seoul National University; 2003.

6.
Lee YS, Kim MK, Kim YI, Shin YS, Lee HJ, Ahn HS. Private practitioners' antimicrobial prescription patterns for acute respiratory infections in children. J Korean Public Health Assoc 1991;17(2):3-19.

7.
Ochoa Sangrador C, Gonzalez de Dios J; Research Group of the aBREVIADo Project. Overuse of bronchodilators and steroids in bronchiolitis of different severity: bronchiolitis-study of variability, appropriateness, and adequacy. Allergol Immunopathol (Madr) 2014;42(4):307-315. DOI: http://dx.doi.org/10.1016/j.aller.2013.02.010. crossref(new window)

8.
Kuna P. Longterm effects of steroid therapy. Wiad Lek 1998;51 Suppl 1:12-18.

9.
Chun YJ, Kim CY. The factors influencing variation by local areas in antibiotics prescription rate according to the public reporting. Korean J Health Policy Admin 2012;2(3):427-450.

10.
Kumari S, Borroni V, Chaudhry A, Chanda B, Massol R, Mayor S, et al. Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway. J Cell Biol 2008;181(7):1179-1193. crossref(new window)

11.
Choi KH, Park SM, Lee JH, Kwon S. Factors affecting the prescribing patterns of antibiotics and injections. J Korean Med Sci 2012;27(2):120-127. DOI: http://dx.doi.org/10.3346/jkms.2012.27.2.120. crossref(new window)

12.
Gjelstad S, Dalen I, Lindbaek M. GPs' antibiotic prescription patterns for respiratory tract infections: still room for improvement. Scand J Prim Health Care 2009;27(4):208-215. DOI: http://dx.doi.org/10.3109/02813430903438718. crossref(new window)

13.
Livni G, Ashkenazi S. Treatment of resistant bacterial infections in children: thinking inside and outside the box. Adv Exp Med Biol 2013;764:123-132. DOI: http://dx.doi.org/10.1007/978-1-4614-4726-9_9.

14.
Health Insurance Review & Assessment Service. Report on the appropriateness of pharmaceutical benefits. Seoul: Health Insurance Review & Assessment Services; 2013.

15.
Britt H, Harrison C, Miller G. The real story, GP prescribing of antibiotics for respiratory tract infections-from BEACH [Internet]. Sydney: FMRC, University of Sydney; 2012 [cited 2015 Sep 20]. Available from: http://sydney.edu.au/medicine/fmrc/beach/bytes/2012-002/.

16.
Akkerman AE, Kuyvenhoven MM, Verheij TJ, van Dijk L. Antibiotics in Dutch general practice: nationwide electronic GP database and national reimbursement rates. Pharmacoepidemiol Drug Saf 2008;17(4):378-383. DOI: http://dx.doi.org/10.1002/pds.1501. crossref(new window)

17.
Wang EE, Einarson TR, Kellner JD, Conly JM. Antibiotic prescribing for Canadian preschool children: evidence of overprescribing for viral respiratory infections. Clin Infect Dis 1999;29(1):155-160. DOI: http://dx.doi.org/10.1086/520145. crossref(new window)

18.
Bronzwaer SL, Cars O, Buchholz U, Molstad S, Goettsch W, Veldhuijzen IK, et al. A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerg Infect Dis 2002;8(3):278-282. DOI: http://dx.doi.org/10.3201/eid0803.010192. crossref(new window)

19.
Goossens H, Ferech M, Vander Stichele R, Elseviers M; ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 2005;365(9459):579-587. DOI: http://dx.doi.org/10.1016/s0140-6736(05)17907-0. crossref(new window)

20.
Coenen S, Ferech M, Haaijer-Ruskamp FM, Butler CC, Vander Stichele RH, Verheij TJ, et al. European Surveillance of Antimicrobial Consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Qual Saf Health Care 2007;16(6):440-445. DOI: http://dx.doi.org/10.1136/qshc.2006.021121. crossref(new window)

21.
Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, et al. European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe (1997-2009). J Antimicrob Chemother 2011;66 Suppl 6:vi3-12. DOI: http://dx.doi.org/10.1093/jac/dkr453.

22.
Harbarth S, Albrich W, Brun-Buisson C. Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective. Emerg Infect Dis 2002;8(12):1460-1467. DOI: http://dx.doi.org/10.3201/eid0812.010533. crossref(new window)

23.
Gonzales R, Anderer T, McCulloch CE, Maselli JH, Bloom FJ Jr, Graf TR, et al. A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. JAMA Intern Med 2013;173(4):267-273. DOI: http://dx.doi.org/10.1001/jamainternmed.2013.1589. crossref(new window)

24.
Tabatabaei SA, Fahimzad SA, Shamshiri AR, Shiva F, Salehpor S, Sayyahfar S, et al. Assessment of a new algorithm in the management of acute respiratory tract infections in children. J Res Med Sci 2012;17(2):182-185.

25.
Hersberger KE, Botomino A, Sarkar R, Tschudi P, Bucher HC, Briel M. Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary care. J Clin Pharm Ther 2009;34(4):387-395. DOI: http://dx.doi.org/10.1111/j.1365-2710.2009.01049.x. crossref(new window)

26.
Little P, Moore M, Kelly J, Williamson I, Leydon G, McDermott L, et al. Delayed antibiotic prescribing strategies for respiratory tract infections in primary care: pragmatic, factorial, randomised controlled trial. BMJ 2014;348:g1606. DOI: http://dx.doi.org/10.1136/bmj.g1606. crossref(new window)

27.
Angoulvant F, Skurnik D, Bellanger H, Abdoul H, Bellettre X, Morin L, et al. Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005-2009. Eur J Clin Microbiol Infect Dis 2012;31(7):1295-1303. DOI: http://dx.doi.org/10.1007/s10096-011-1442-4. crossref(new window)

28.
Kang H. Efforts to improve antibiotic prescribing trends for acute upper respiratory infections in a South Korean University hospital. Korean J Clin Pharm 2012:22(1);47-54.

29.
Pulcini C, Gyssens IC. How to educate prescribers in antimicrobial stewardship practices. Virulence 2013;4(2):192-202. DOI: http://dx.doi.org/10.4161/viru.23706. crossref(new window)

30.
Kim DS, Kim YJ, Lee HS, Bae G, Kim SK, Lee SH. Retrospective drug utilization review of antibiotics for respiratory tract infection (RTI) in ambulatory outpatient care. Korean J Clin Pharm 2012:22(4);291-303.