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Bioassay in BALB/c mice exposed to low dose rate radiation
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 Title & Authors
Bioassay in BALB/c mice exposed to low dose rate radiation
Kim, Sung-Dae; Gong, Eun-Ji; Bae, Min-Ji; Yang, Kwang-Mo; Kim, Joong-Sun;
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 Abstract
The present study was performed to investigate the toxicity of low-dose-rate irradiation in BALB/c mice. Twenty mice of each sex were randomly assigned to four groups of five mice each and were exposed to 0 (sham), 0.02, 0.2, or 2 Gy, equivalents to low-dose-rate irradiation to 3.49 . Urine, blood, and blood biochemistry were analyzed, and organ weight was measured. The low-dose-rate irradiation did not induce any toxicologically significant changes in mortality, clinical signs, body weight, food and water consumption, urinalysis, and serum biochemistry. However, the weights of reproductive organs including the testis, ovary, and uterus decreased in a dose-dependent manner. Irradiation at 2 Gy significantly decreased the testis, ovary, and uterus weights, but did not change the weights of other organs. There were no adverse effects on hematology in any irradiated group and only the number of neutrophils increased dose dependently. The low-dose-rate irradiation exposure did not cause adverse effects in mice at dose levels of 2 Gy or less, but the reproductive systems of male and female mice showed toxic effects.
 Keywords
Low-dose-rate irradiation;Toxicity;Mice;Testis;Ovary;
 Language
Korean
 Cited by
1.
DOSE AND DOSE RATE EFFECTS OF IRRADIATION ON BLOOD COUNT AND CYTOKINE LEVEL IN BALB/c MICE,;;;;;;

Journal of Radiation Protection and Research, 2013. vol.38. 4, pp.179-184 crossref(new window)
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Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma, PLOS ONE, 2015, 10, 11, e0143403  crossref(new windwow)
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Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis, Journal of Radiation Research, 2014, 55, 1, 54  crossref(new windwow)
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DOSE AND DOSE RATE EFFECTS OF IRRADIATION ON BLOOD COUNT AND CYTOKINE LEVEL IN BALB/c MICE, Journal of Radiation Protection and Research, 2013, 38, 4, 179  crossref(new windwow)
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