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DOSE AND DOSE RATE EFFECTS OF IRRADIATION ON BLOOD COUNT AND CYTOKINE LEVEL IN BALB/c MICE
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 Title & Authors
DOSE AND DOSE RATE EFFECTS OF IRRADIATION ON BLOOD COUNT AND CYTOKINE LEVEL IN BALB/c MICE
Son, Yeonghoon; Jung, Dong Hyuk; Kim, Sung Dae; Lee, Chang Geun; Yang, Kwangmo; Kim, Joong Sun;
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 Abstract
The biological effects of radiation are dependent on the dose rate and dose of radiation. In this study, effects of dose and dose rate using whole body radiation on plasma cytokines and blood count from male BALB/c mice were evaluated. We examined the blood and cytokine changes in mice exposed to a low (3.49m Gy ) and high (2.6 Gy ) dose rate of radiation at a total dose of 0.5 and 2 Gy, respectively. Blood from mice exposed to radiation were evaluated using cytokine assays and complete blood count. Peripheral lymphocytes and neutrophils decreased in a dose dependent manner following high dose rate radiation. The peripheral lymphocytes population remained unchanged following low dose rate radiation; however, the neutrophils population increased after radiation. The sera from these mice exhibited elevated levels of flt3 ligand and granulocyte-colony-stimulating factor (G-CSF), after high/low dose rate radiation. These results suggest that low-dose-rate radiation does not induce blood damage, which was unlike high-dose-rate radiation treatment; low-dose-rate radiation exposure activated the hematopoiesis through the increase of flt3 ligand and G-CSF.
 Keywords
Radiation;Dose rate;Blood;Cytokine assay;G-CSF;flt3 ligand;
 Language
English
 Cited by
1.
마우스에서 전신 저선량 분할 방사선 조사에 의한 면역학적 변화 평가,김미형;유상영;임대석;송지영;

Journal of Radiation Protection and Research, 2014. vol.39. 3, pp.134-141 crossref(new window)
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Effects of Low-Dose Fractionated Total Body Irradiation on Murine Immune System, Journal of Radiation Protection, 2014, 39, 3, 134  crossref(new windwow)
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