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Organ Weights and Splenocytic Apoptosis in γ-irradiated Korean Dark-Striped Field Mice, Apodemus Agrarius Coreae
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 Title & Authors
Organ Weights and Splenocytic Apoptosis in γ-irradiated Korean Dark-Striped Field Mice, Apodemus Agrarius Coreae
Joo, Hyunjin; Choi, Hoon; Yang, Kwang-hee; Keum, Dong-kwon; Kim, Hee sun;
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The present investigation was planned to estimate potential possibility of striped field mice, Apodemus agrarius coreae (A. a. coreae), as a biological dosimeter in radio-environmental ecology. We bred captured wild A. a. coreae at laboratory and classified taxonomically based on external, cranial and tooth characters. Organ weights and splenocytic apoptosis were observed in order to establish a basic data on radiation biology of A. a. coreae (male, 40 weeks old). The biological effects was observed at 24hrs following irradiation (doses : 0, 0.5, 1, 2 Gy, dose rate : , ). Only thymus weights was significantly decreased. Splenocytic apoptosis was increased after irradiation. But splenocytic apoptosis was decreased in 0.5 Gy -irradiated mice compared to those of 0, 1, 2 Gy (P < 0.05). These data suggested that events in thymus and spleen of Korean dark-striped field mice, A. a. coreae THOMAS, could be a potential radio-biological indicator in human environments.
Radio-environmental indicator;Apodemus;Radiation;Organ weights;Spleenocytes;Apoptosis;
 Cited by
International Atomic Energy Agency. A methodology for assessing impacts of radioactivity on aquatic ecosystems. IAEA Technical Reports Series No 190. 1979.

International Atomic Energy Agency. Assessing the effect of deep sea disposal of low level radioactive waste on living organisms. IAEA Technical Reports Series No 288. 1988.

International Atomic Energy Agency. Effects of ionizing radiation on plants and animals at levels implied by current radiation protection standards. IAEA Technical Reports Series No 322. 1992.

International Atomic Energy Agency. Ethical considerations in protecting the environment from the effects of ionizing radiation. IAEA. 2002.

Shirashi K, Yamamoto M. Internal dose from ingestion for Japanese adult males. Health Phys. 1996;71(5):700-704. crossref(new window)

Tagami K, Uchiyama S. Analysis of Technetium-99 in soil and deposition samples by inductively coupled plasma mass spectrometry. Appl Radiat Isotopes. 1996;47:1057-1060. crossref(new window)

Yukawa M, Watanabe Y, Nishimura Y, Guo Y, Yongru Z, Lu H, Wei L, Tao Z. Determination of U and Th in soil and plants obtained from a high natural radiation area in China using ICP-MS and ${\gamma}$-counting. Fresenius J Anal Chem. 1999;363: 760-777. crossref(new window)

Kim JK, Lee YK, Kim JS, Shin HS, Hyun HS. Effects of combined irradiation of neutrons and gamma rays on the pink mutation frequencies in Tradescantia. J Radiat Prot. 2000;25(2):67-73.

Kim R, Han DU, Lim JT, Jo SK, Kim TH. Induction of micronuclei in human, goat, rabbit peripheral blood lymphocytes and mouse splenic lymphocytes irradiated in vitro with gamma radiation. Mutat Res. 1997;393(3):207-214. crossref(new window)

Roderick T. The response of twenty-seven inbred strains of mice to dairy doses of whole-body X-irradiation. Radiation Res. 1963;20:631-639. crossref(new window)

Yonezawa M, Misonoh J, Hosokawa Y. Two types of X-ray-induced radioresistance in mice: Presence of 4 dose ranges with distinct biological effects. Mutat Res. 1996;358:237-243. crossref(new window)

Wickliffe JK, Chesser RK, Rodgers BE, Baker RJ. Assessing the genotoxicity of chronic environmental irradiation by using mitochondria DNA heteroplasmy in the bank vole (Clethrionomys glareolus) at Chornobyl. Ukraine Environ Toxicol Chem. 2005;21(6):1249-1254.

Abramsson-Zetterberg LJG, Zetterberg G. Spontaneous and radiation-induced micronuclei in erythrocytes from four species of wild rodents: a comparison with CBA mice. Mutat Res. 1997;393(1-2): 55-71. crossref(new window)

Tsiperson VP, Soloviev MY. The impact of chronic radioactive stress on the immuno- physiological condition of small mammals. Sci Total Environ. 1997;203(2):105-113. crossref(new window)

Woon BO. Illustrated encyclopedia of fauna and flora of Korea. Vol. 7. Mammals. 1967:214-222.

Koh HS. A study on age variation and secondary sexual dimorphism in morphometric characters of korean rodents: I. An analysis on striped field mice, Apodemus agrarius coreae Thomas, from Cheongju. Korean J Zool. 1983;26(2):125-134.

Jones JK, Johnson DH. Synopsis of the lagomorphs and rodents of Korea. University of Kansas Publications, Museum of Natural History. 1965;16(2):357-407.

Cobet GB. The mammals of the palaearctic region: a taxonomic review. British Museum (Natural History), Cornell University Press. 1978: 130-137.

Choi JM, Kim HS, Yang KH, Kim CS, Lim YK, Kim CS, Woon JH. Acridine orange stained micronucleus assay in human B and T-lymphocytes after low dose ${\gamma}$-irradiation. J Radiat Prot. 2004; 29(1):9-15.

Vral A, Louagie H, Thierens H, Philippe M, Ridder L. Micronucleus frequences in cytokinesis-blocked human B lymphocytes after low dose gamma-irradiation. Int J Radiat Biol. 1998;73: 549-555. crossref(new window)

Bong JJ, Kang YM, Shin SC, Choi SJ, Lee KM, Kim HS. Differential expression on thymic DNA repair genes in low-dose-rate irradiate AKR/J mice. J Vet Sci. 2013;14(3):271-279. crossref(new window)