Advanced SearchSearch Tips
Seaweed Derived Oligosaccharides and its Health Beneficial Effects on Gut Health
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Seaweed Derived Oligosaccharides and its Health Beneficial Effects on Gut Health
Yang, Hyosun; Lee, Yunkyoung;
  PDF(new window)
The incidence of inflammatory bowel disease(IBD) has increased continuously in worldwide, but no cure have been discovered. The etiology of IBD may include various factors such as genetics, epigenetic, environment as well as host immune system. Among the environmental factors of IBD, diet heavily influences gut health, especially non-digestible dietary fiber can have a great impact on selective growth of beneficial gut microbiota called probiotics. Seaweeds have been consumed in Asia countries and are a rich source for dietary fiber. Accumulated data have suggested the possibility of utilizing seaweed derived oligosaccharides as prebiotics to prevent IBD and its recurrence. In this review, seaweed derived oligosaccharides such as fucoidan and laminarin regarding gut health and potential therapeutic tools for IBD will be discussed based on studies conducted in vitro and in vivo models.
Seaweed;Oligosaccharides;Gut Health;Inflammatory Bowel Disease;Prebiotics;
 Cited by
P. Bourlioux, B. Koletzko, and F. Guarner, "The Intestine and its Microflora are Partners for the Protection of the Host," Am J. of Clinical Nutrition, Vol.78, No.4, pp.675-683, 2003. crossref(new window)

D. Hollander, "Intestinal Permeability, Leaky Gut, and Intestinal Disorders," Current Gastroenterology Reports, Vol.1, No.5, pp.410-416, 1999. crossref(new window)

M. Silverman and M. Ostro, "Bacterial Endotoxin in Human Disease," Princeton, NJ: KPMG, Vol.35, 1999.

E. Y. Choi, K. K. Cho, and I. S. Choi, "Inflammatory Bowel Disease and Cytokine," J Life Sciences, Vol.23, No.3, pp.448-461, 2013.

장병익, "염증성 장질환의 최신지견," 영남의대학술지, 제24권, 제2호, pp.S221-S233, 2007.

R. Rahimi, S. Nikfar, and M. Abdollahi, "Induction of Clinical Response and Remission of Inflammatory Bowel Disease by use of Herbal Medicines: A Meta-Analysis," World J gastroenterol, Vol.19, No.34, pp.5738-5749, 2003.

L. J. Dixon, A. Kabi, and K. P. Nickerson, "Combinatorial effects of diet and genetics inflammatory bowel disease pathogenesis," Inflammatory bowel diseases, Vol.21, pp.912-922, 2015. crossref(new window)

G. D. Wu, J. Chen, and C. Hoffmann, "Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes," Science, Vol.334, No.6052, pp.105-108, 2011. crossref(new window)

D. E. Serban, "Microbiota in inflammatory bowel disease pathogenesis and therapy: Is it all about diet?," Nutrition in Clinical Practice, Vol.30, pp.760-779, 2015. crossref(new window)

P. Louis, G. L. Hold, and H. J. Flint, "The Gut Microbiota, Bacterial Metabolites and Colorectal Cancer," Nature reviews Microbiology, Vol.12, pp.661-672, 2014 crossref(new window)

G. R. Glenn and M. B. Roberfroid, "Dietary modulation of the human colonic microbiota," J of nutrition, Vol.125, No.6, pp.1401-1412, 1995.

P. R. Marteau, M. de Vrese, and C. J. Cellier, "Protection from Gastrointestinal Diseases with the use of Probiotics," The American J of Clinical Nutrition, Vol.73, No.2, pp.430S-436S, 2001. crossref(new window)

이신지, 이명종, 정지은, "장내 상피세포 점막 투과성에 대한 유산균 및 금은화의 효과," 한국식품영양과학회지, 제41권, 제7호, pp.881-887, 2012.

S. U. Kadam, B. K. Tiwari, and C. P. O'Donnell, "Extraction, Structure and Biofunctional Activities of Laminarin from Brown Algae," International J of Food Science and Technology, Vol.50, No.1, pp.24-31, 2015 crossref(new window)

J. Kang, M. Khan, and N. Park, "Antipyretic, Analgesic, and Anti-Inflammatory Activities of the Seaweed Sargassum Fulvellum and Sargassum Thunbergii in Mice," J of Ethnopharmacology, Vol.116, No.1, pp.187-190, 2008. crossref(new window)

Y. V. Yuan and N. A. Walsh, "Antioxidant and Antiproliferative Activities of Extracts from a Variety of Edible Seaweeds," Food and Chemical Toxicology, Vol.44, No.7, pp.1144-1150, 2006. crossref(new window)

A. Val, G. Platas, and A. Basilio, "Screening of Antimicrobial Activities in Red, Green and Brown Macroalgae from Gran Canaria," International Microbiology, Vol.4, No.1, pp.35-40, 2001.

W. A. Pushpamali, C. Nikapitiya, and M. De Zoysa, "Isolation and Purification of an Anticoagulant from Fermented Red Seaweed Lomentaria Catenata," Carbohydrate Polymers, Vol.73, No.2, pp.274-279, 2008. crossref(new window)

L. O'Sullivan, B. Murphy, and P. McLoughlin, "Prebiotics from Marine Macroalgae for Human and Animal Health Applications," Marine drugs, Vol.8, No.7, pp.2038-2064, 2010. crossref(new window)

E. V. Loftus, "Clinical Epidemiology of Inflammatory Bowel Disease: Incidence, Prevalence, and Environmental Influences," Gastroenterology, Vol.126, No.6, pp.1504-1517, 2004. crossref(new window)

D. H. Shin, D. H. Sinn, and Y. Kim, "Increasing Incidence of Inflammatory Bowel Disease among Young Men in Korea between 2003 and 2008," Digestive Diseases and Science, Vol.56, No.4, pp.1154-1159, 2011. crossref(new window)

W. Strober, I. Fuss, and P. Mannon, "The Fundamental Basis of Inflammatory Bowel Disease," J of Clinical Investigation, Vol.117, No.3, pp.514-521, 2007. crossref(new window)

S. Wirtz and M. F. Neurath, "Mouse models of inflammatory bowel disease," Advanced Drug Delivery Reviews, Vol.59, No.11, pp.1073-1083, 2007. crossref(new window)

J. O. Clarke and G. E. Mullin, "A Review of Complementary and Alternative Approaches to Immunomodulation," Nutrition in Clinical Practice, Vol.23, No.1, pp.49-62, 2008. crossref(new window)

A. Iraha, H. Chinen, and A. Hokama, "Fucoidan Enhances Intestinal Barrier Function by Upregulating the Expression of Claudin-1," World J of Gastroenterology, Vol.19, No.33, pp.5500-5507, 2013. crossref(new window)

G. Rogler, "Gastrointestinal and Liver Adverse Effects of Drugs used for Treating IBD," Best Practice & Research Clinical Gastroenterology, Vol.24, No.2, pp.157-165, 2010. crossref(new window)

S. Matsumoto, M. Nagaoka, and T. Hara, "Fucoidan Derived from Cladosiphon Okamuranus Tokida Ameliorates Murine Chronic Colitis through the Down Regulation of IL-6 Production on Colonic Epithelial Cells," Clinical and Experimental Immunology, Vol.136, No.3, pp.432-439, 2004. crossref(new window)

C. Deville, M. Gharbi, and G. Dandrifosse, "Study on the Effects of Laminarin, a Polysaccharide from Seaweed, on Gut Characteristics," J of the Science of Food and Agriculture, Vol.87, No.9, pp.1717-1725, 2007. crossref(new window)

P. Reilly, J. O'doherty, and K. Pierce, "The Effects of Seaweed Extract Inclusion on Gut Morphology, Selected Intestinal Microbiota, Nutrient Digestibility, VFA Concentrations and the Immune Status of the Weaned Pig," Animal, Vol.2, No.10, pp.1465-1473, 2008.

T. Tanoue, Y. Nishitani, and K. Kanazawa, "In Vitro Model to Estimate Gut Inflammation using Co-Cultured Caco-2 and RAW264. 7 Cells," Biochemical and Biophysical ResearchCommunications, Vol.374, No.3, pp.565-569, 2008. crossref(new window)

A. G. Smith, J. O'Doherty, and P. Reilly, "The Effects of Laminarin Derived from Laminaria Digitata on Measurements of Gut Health," British J of Nutrition, Vol.105, No.5, pp.669-677, 2011. crossref(new window)

S. J. Ko, Y. Bu, and J. Bae, "Protective Effect of Laminaria Japonica with Probiotics on Murine Colitis," Mediators of Inflammation, Vol.2014, pp.1-10, 2014.

M. Lahaye, "Marine Algae as Sources of Fibres: Determination of Soluble and Insoluble Dietary Fibre Contents in some 'sea Vegetables'," Journal of Science of Food and Agriculture, Vol.54, No.4, pp.587-594, 1991. crossref(new window)

M. Miyata, T. Koyama, and T. Kamitani, "Anti-Obesity Effect on Rodents of the Traditional Japanese Food, Tororokombu, Shaved Laminaria," Bioscience, Biotechnology, and Biochemistry, Vol.73, No.10, pp.2326-2328, 2009. crossref(new window)

A. Jimenez-Escrig and F. Sanchez-Muniz, "Dietary Fibre from Edible Seaweeds: Chemical Structure, Physicochemical Properties and Effects on Cholesterol Metabolism," Nutritional Research, Vol.20, No.4, pp.585-598, 2000. crossref(new window)

E. Gomez-Ordonez, A. Jimenez-Escrig, and P. Ruperez, "Dietary Fibre and Physicochemical Properties of several Edible Seaweeds from the Northwestern Spanish Coast," Food Research International, Vol.43, No.9, pp.2289-2294, 2010. crossref(new window)

이명숙, 이윤경, "해조류의 섭취가 비만과 식이섭취에 미치는 영향," 한국콘텐츠학회논문지, 제14권, 제12호, pp.478-485, 2014.

J. Y. Oh, Bioactivity of secondary metabolites and growth activity of lactic acid bacteria (LAB) under modified seaweed culture medium, MS Thesis, Jeju National University, 2014.

T. Debnath, D. H. Kim, and B. O. Lim, "Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease," Molecules, Vol.18, No.6, pp.7253-7270, 2013. crossref(new window)

J. H. Cummings, "Short chain fatty acids in the human colon," Gut, Vol.22, No.9, pp.763-779, 1981. crossref(new window)

D. R. Donohoe, G. Nikhil, and X. Zhang, "The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon," Cell Metabolism, Vol.13, No.5, pp.517-526, 2011. crossref(new window)