Advanced SearchSearch Tips
Association between periodontitis and preterm birth and low birth weight
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Association between periodontitis and preterm birth and low birth weight
Ha, Jung-Eun;
  PDF(new window)
The purpose of the review article is to investigate the influence of periodontal diseases on preterm birth(PTB) and low birth weight(LBW). PTB and LBW are the main risk factors of infant mortality and a major public health problem. PTB is defined as delivery at less than 37 weeks and LBW is less than 2,500 grams. Over Approximately 60 percent of perinatal mortality results from PTB or LBW. Although the causes of PTB and LBW are not fully understood, infection is the leading cause of PTB and LBW. Periodontal diseases are serious disease burdens because they are caused by bacterial endotoxin, inflammatory reaction, and cytokine. The periodontal diseases are the predisposing factors of cerebrovascular and cardiovascular diseases including atherosclerosis. Over the past 15 years, previous studies revealed that periodontitis had adverse outcomes including PTB and LBW in pregnancy.
low birth weight;periodontitis;pregnancy;preterm birth;
 Cited by
Amar S, Cung KM. Influence of hormonal variation on the periodontium in women. Periodontol 2000 1994; 6(1): 79-87. crossref(new window)

Gursoy M, Pajukanta R, Sorsa T, Kononen E. Clinical changes in periodontium during pregnancy and post-partum. J Clin Periodontol 2008; 35(7): 576-83. crossref(new window)

Carrillo-de-Albornoz A, Figuero E, Herrera D, Bascones-Martinez A. Gingival changes during pregnancy: II. Influence of hormonal variations on the subgingival biofilm. J Clin Periodontol 2010; 37(3): 230-40. crossref(new window)

Boggess KA, Edelstein BL. Oral health in women during preconception and pregnancy: implications for birth outcomes and infant oral health. Matern Child Health J 2006; 10(Suppl 5): 169S-74S. crossref(new window)

Khader Y, Taani Q. Periodontal diseases and the risk of preterm birth and low birth weight: a meta-analysis. J Periodontol 2005; 76(2): 161-5. crossref(new window)

Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 1996; 67(Suppl 10): 1103S-13S. crossref(new window)

Dasanayake AP. Poor periodontal health of the pregnant woman as a risk factor for low birth weight. Ann Periodontol 1998; 3(1): 206-12. crossref(new window)

Cohen DW, Shapiro J, Friedman L, Kyle GC, Franklin S. A longitudinal investigation of the periodontal changes during pregnancy and fifteen months post-partum. II. J Periodontol 1971; 42(10): 653-7. crossref(new window)

Kornman KS, Loesche WJ. The subgingival microbial flora during pregnancy. J Periodontal Res 1980; 15(2): 111-22. crossref(new window)

Miyazaki H, Yamashita Y, Shirahama R, Goto-Kimura K, Shimada N, Sogame A, et al. Periodontal condition of pregnant women assessed by CPITN. J Clin Periodontol 1991; 18(10): 751-4. crossref(new window)

Tilakaratne A, Soory M, Ranasinghe AW, Corea SM, Ekanayake SL, De Silva M. Effects of hormonal contraceptives on the periodontium, in a population of rural Sri-Lankan women. J Clin Periodontol 2000; 27(10): 753-7. crossref(new window)

Buduneli N, Becerik S, Buduneli E, Baylas H, Kinnby B. Gingival status, crevicular fluid tissue-type plasminogen activator, plasminogen activator inhibitor-2 levels in pregnancy versus post-partum. Aust Dent J 2010; 55(3): 292-7. crossref(new window)

Xie Y, Xiong X, Elkind-Hirsch KE, Pridjian G, Maney P, Delarosa RL, et al. Change of periodontal disease status during and after pregnancy. J Periodontol 2013; 84(6): 725-31. crossref(new window)

Gursoy M, Haraldsson G, Hyvonen M, Sorsa T, Pajukanta R, Kononen E. Does the frequency of Prevotella intermedia increase during pregnancy? Oral Microbiol Immunol 2009; 24(4): 299-303. crossref(new window)

Adriaens LM, Alessandri R, Sporri S, Lang NP, Persson GR. Does pregnancy have an impact on the subgingival microbiota? J Periodontol 2009; 80(1): 72-81. . crossref(new window)

Figuero E, Carrillo-de-Albornoz A, Herrera D, Bascones-Martinez A. Gingival changes during pregnancy: I. Influence of hormonal variations on clinical and immunological parameters. J Clin Periodontol 2010; 37(3): 220-9. crossref(new window)

Ha JE, Yeo BM, Roh HY, Paik DI, Bae KH. Periodontal condition and pathogens distribution of pregnant women. J Korean Acad Oral Health 2010; 34(4): 587-94.

Centers for Disease Control. The update: incidence of low birth weight. MMWR Morb Mortal Wkly Rep 1984; 33(32): 459-60.

Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, et al. The preterm parturition syndrome. BJOG 2006; 113(Suppl 3): 17S-42S.

Goldenberg RL, Culhane JF. Prepregnancy health status and the risk of preterm delivery. Arch Pediatr Adolesc Med 2005; 159(1): 89-90. crossref(new window)

Kramer MS. Determinants of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ 1987; 65(5): 663-737.

Williams RL, Creasy RK, Cunningham GC, Hawes WE, Norris FD, Tashiro M. Fetal growth and perinatal viability in California. Obstet Gynecol 1982; 59(5): 624-32.

Kramer MS. The epidemiology of adverse pregnancy outcomes: an overview. J Nutr 2003; 133(Suppl 5): 1592S-6S. crossref(new window)

Miller WD. The human mouth as a focus of infection. Lancet 1891; 138(3546): 340-2.. crossref(new window)

Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect 2007; 13(Suppl 4): 3S-10S. crossref(new window)

Hung HC, Willet W, Merchant A, Rosner BA, Ascherio A, Joshipura KJ. Oral health and peripheral arterial disease. Circulation 2003; 107(8): 1152-7. crossref(new window)

Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol 2006; 77(8): 1289-1303. crossref(new window)

Madianos PN, Bobetsis YA, Offenbacher S. Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms. J Clin Periodontol 2013; 40(Suppl 4): 170S-80S. crossref(new window)

Haram K, Mortensen JH, Wollen AL. Preterm delivery:an overview. Acta Obstet Gynecol Scand 2003; 82(8): 687-704. crossref(new window)

Collins JG, Smith MA, Arnold RR, Offenbacher S. Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. Infect Immun 1994; 62(10): 4652-5.

Offenbacher S, Jared HL, O'Reilly PG, Wells SR, Salvi GE, Lawrence HP, et al. Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol 1998; 3(1): 233-50. crossref(new window)

Madianos PN, Lieff S, Murtha AP, Boggess KA, Auten RL Jr, Beck JD, et al. Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Ann Periodontol 2001; 6(1): 175-82. crossref(new window)

Buduneli N, Baylas H, Buduneli E, Turkoglu O, Kose T, Dahlen G. Periodontal infections and pre-term low birth weight: a case-control study. J Clin Periodontol 2005; 32(2): 174-81. crossref(new window)

Davenport ES, Williams CE, Sterne JA, Murad S, Sivapathasundram V, Curtis MA. Maternal periodontal disease and preterm low birthweight: case-control study. J Dent Res 2002; 81(5): 313-8. crossref(new window)

Moore S, Randhawa M, Ide M. A case-control study to investigate an association between adverse pregnancy outcome and periodontal disease. J Clin Periodontol 2005; 32(1): 1-5. crossref(new window)

Noack B, Klingenberg J, Weigelt J, Hoffmann T. Periodontal status and preterm low birth weight: a case control study. J Periodontal Res 2005; 40(4): 339-45. crossref(new window)

Skuldbol T, Johansen KH, Dahlen G, Stoltze K, Holmstrup P. Is pre-term labour associated with periodontitis in a Danish maternity ward? J Clin Periodontol 2006; 33(3): 177-83. crossref(new window)

Vettore MV, Leal Md, Leao AT, da Silva AM, Lamarca GA, Sheiham A. The relationship between periodontitis and preterm low birthweight. J Dent Res 2008; 87(1): 73-8. crossref(new window)

Nabet C, Lelong N, Colombier ML, Sixou M, Musset AM, Goffinet F, et al. Maternal periodontitis and the causes of preterm birth: the case-control Epipap study. J Clin Periodontol 2010; 37(1): 37-45. crossref(new window)

Choi EC, Ku Y, Rhyu IC, Hahm BD, Yoon BH, Han SB, et al. Relationship between Preterm Low Birth Weight and Periodontal Disease Activity in Pregnancy. J Korean Acad Periodontol 2000; 30(1): 111-9. crossref(new window)

Ryu JI, Oh K, Yang H, Choi BK, Ha JE, Jin BH, et al. Health behaviors, periodontal conditions, and periodontal pathogens in spontaneous preterm birth: a case-control study in Korea. J Periodontol 2010; 81(6): 855-63. crossref(new window)

Goepfert AR, Jeffcoat MK, Andrews WW, Faye-Petersen O, Cliver SP, Goldenberg RL, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004; 104(4): 777-83. crossref(new window)

Radnai M, Gorzo I, Urban E, Eller J, Novak T, Pal A. Possible association between mother's periodontal status and preterm delivery. J Clin Periodontol 2006; 33(11): 791-6. crossref(new window)

Jeffcoat MK, Geurs NC, Reddy MS, Cliver SP, Goldenberg RL, Hauth JC. Periodontal infection and preterm birth: results of a prospective study. J Am Dent Assoc 2001; 132(7): 875-80. crossref(new window)

Lopez NJ, Smith PC, Gutierrez J. Higher risk of preterm birth and low birth weight in women with periodontal disease. J Dent Res 2002; 81(1): 58-63. crossref(new window)

Moore S, Ide M, Coward PY, Randhawa M, Borkowska E, Baylis R, et al. A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome. Br Dent J 2004; 197(5): 251-8. crossref(new window)

Rajapakse PS, Nagarathne M, Chandrasekra KB, Dasanayake AP. Periodontal disease and prematurity among non-smoking Sri Lankan women. J Dent Res 2005; 84(3): 274-7. crossref(new window)

Farrell S, Ide M, Wilson RF. The relationship between maternal periodontitis, adverse pregnancy outcome and miscarriage in never smokers. J Clin Periodontol 2006; 33(2): 115-20. crossref(new window)

Offenbacher S, Boggess KA, Murtha AP, Jared HL, Lieff S, McKaig RG, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol 2006; 107(1): 29-36. crossref(new window)

Toygar HU, Seydaoglu G, Kurklu S, Guzeldemir E, Arpak N. Periodontal health and adverse pregnancy outcome in 3,576 Turkish women. J Periodontol 2007; 78(11): 2081-94. crossref(new window)

Agueda A, Ramón JM, Manau C, Guerrero A, Echeverria JJ. Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 2008; 35(1): 16-22.

Vogt M, Sallum AW, Cecatti JG, Morais SS. Periodontal disease and some adverse perinatal outcomes in a cohort of low risk pregnant women. Reprod Health 2010; 7(1): 29. crossref(new window)

Al Habashneh R, Khader YS, Jabali OA, Alchalabi H. Prediction of preterm and low birth weight delivery by maternal periodontal parameters: receiver operating characteristic (ROC) curve analysis. Matern Child Health J 2013; 17(2): 299-306. crossref(new window)

Lee KY, Won BY. A study on the oral health care of pregnant women in a region. J Korean Soc Dent Hyg 2009; 9(1): 1-14. crossref(new window)

Kim MJ, Lee HK, Kim YI. Some areas of oral health status of pregnant women. J Korean Soc Dent Hyg 2010; 10(2): 323-34.