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Composition of Biologically Active Substances and Antioxidant Activity of New Zealand Deer Velvet Antler Extracts
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 Title & Authors
Composition of Biologically Active Substances and Antioxidant Activity of New Zealand Deer Velvet Antler Extracts
Je, Jae-Young; Park, Pyo-Jam; Kim, Eun-Kyung; Kim, Hyun-A; Lim, Dong-Hwan; Jeon, Byong-Tae; Ahn, Chang-Bum;
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Deer velvet antler was subjected to the extraction process using boiling water at three different temperatures (100, 110 and ) and 70% ethanol solution. Functional components such as uronic acid, sulfated-glycosaminoglycans (sulfated-GAGs) and sialic acid in the extracts were analyzed, and their antioxidant activities were investigated using several in vitro models. Uronic acid and sulfated-GAGs content of each extract significantly decreased with increasing extraction temperature (p<0.05), while the residues obtained from the upper and middle part of the antler had a higher uronic acid content than the residues obtained from the base section. Sialic acid contents were highest in compounds extracted at , followed by 120 and . The 70% ethanol extracts also had a high levels of uronic acid content, but not for sulfated-GAGs and sialic acid. All extracts showed good antioxidant ability in a dose-dependant manner, with the residue exhibiting the strongest activity compared to the 110 and extracts. In relation to the hydroxyl radical scavenging activity and reduction power, the 70% ethanol extract exhibited the strongest activity. Furthermore, the velvet antler extracts inhibited apoptosis in hydrogen peroxide-induced PC-12 cells.
velvet antler;uronic acid;sulfated-GAGs;sialic acid;antioxidant activity;
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