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Screening of Antiviral Medicinal Plants against Avian Influenza Virus H1N1 for Food Safety
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 Title & Authors
Screening of Antiviral Medicinal Plants against Avian Influenza Virus H1N1 for Food Safety
Lee, Jang-Hyun; Van, Nguyen Dinh; Ma, Jin-Yeul; Kim, Young-Bong; Kim, Soo-Ki; Paik, Hyun-Dong;
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 Abstract
Various extracts from 30 medicinal plants were evaluated for their antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) and cytotoxicity in MDCK cell culture. The plant material (30 g) was extracted with methanol (300 mL) at room temperature for 24 h, after which the methanolic extracts were filtered, evaporated, and subsequently lyophilized. Evaluation of the potential antiviral activity was conducted by a viral replication inhibition test. Among these medicinal plants, Tussilago farfara, Brassica juncea, Prunus armeniaca, Astragalus membranaceus, Patrinia villosa, and Citrus unshiu showed marked antiviral activity against influenza virus A/H1N1 at concentrations ranging from 0.15625 mg/mL to 1.25 mg/mL, 0.3125 mg/mL to 10 mg/mL, 5 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL, and 0.3125 mg/mL to 5 mg/mL, respectively. The extracts of Tussilago farfara showed cytotoxicity at concentrations greater than 2.5 mg/mL, whereas the other five main extracts showed no cytotoxicity at concentrations of 10 mg/mL. Taken together, the present results indicated that methanolic extracts of the six main plants might be useful for the treatment of influenza virus H1N1.
 Keywords
influenza virus H1N1;avian influenza;antiviral activity;medicinal plant;Tussilago farfara;Brassica juncea;Prunus armeniaca;Astragalus membranaceus;Patrinia villosa;Citrus unshiu;
 Language
English
 Cited by
1.
Methicillin 저항성 Staphylococcus aureus에 대한 선복화(Inula britannica flowers) 추출물의 항균효과,이나경;이장현;이용주;안신혜;엄수진;백현동;

한국미생물생명공학회지, 2013. vol.41. 3, pp.335-340 crossref(new window)
1.
Short communication: Antiviral activity of subcritical water extract of Brassica juncea against influenza virus A/H1N1 in nonfat milk, Journal of Dairy Science, 2014, 97, 9, 5383  crossref(new windwow)
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