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Influence of Coating Materials and Emulsifiers on Nanoparticles in Manufacturing Process
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 Title & Authors
Influence of Coating Materials and Emulsifiers on Nanoparticles in Manufacturing Process
Kim, Byeong-Cheol; Chun, Ji-Yeon; Park, Young-Mi; Hong, Geun-Pyo; Lee, Si-Kyong; Choi, Mi-Jung;
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The objective of this study was to investigate the influence of emulsion processing with various homogenization treatments on the physical properties of nanoparticles. For the manufacturing of nanoparticles, by taking the emulsion-diffusion method, various coating materials, such as gum arabic, hydroxyethyl starch, polycarprolactone, paraffin wax, -carrageenan and emulsifiers like Tween60, Tween80, monoglyceride and PluronicF68, were added into the emulsion system. Furthermore, the various speeds (7,000 rpm to 10,000 rpm), and times (15 s to 60 s) of homogenization were treated during the emulsion- diffusion process. NEO II homomixer was the most effective homogenizer for making nanoparticles as 51 nm () and 26 nm (). To manufacture smaller nanoparticles, by using NEO II homomixer, 10,000 rpm of agitation speed, polycaprolactone as coating material, and PluronicF68 as an emulsifier were the optimum operating conditions and components. For the stability of nanoparticles for 7 days, of storage temperature was appropriate to maintain the particle size. From these results, the type of homogenizer, homogenization speed, homogenization time and storage temperature could affect the particle size. Moreover, type of coating materials and emulsifier also influenced the size and stability of the nanoparticles.
nanoparticle;encapsulation;type of homogenizer;coating material;emulsifier;
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고압 균질기를 이용한 커큐민 함유 나노에멀젼의 제조,조연지;이슬비;이재권;권윤중;

산업식품공학, 2014. vol.18. 4, pp.341-347 crossref(new window)
Physical and antimicrobial properties of trans-cinnamaldehyde nanoemulsions in water melon juice, LWT - Food Science and Technology, 2015, 60, 1, 444  crossref(new windwow)
Preparation of Nanoemulsions Containing Curcumin by High Pressure Homogenization, Food Engineering Progress, 2014, 18, 4, 341  crossref(new windwow)
Adamson, A. W. (1990) Physical chemistry of surfaces, fifth edition. John Wiley & Sons, Chichester, NY, Chapter. 10.

Arriagada, F. J. and Osseo, A. K. (1999) Synthesis of nanosize silica in a nonionic water-in oil microemulsion: Effects of the water/surfactant molar ratio and ammonia concentration. J. Colloid. Interface. Sci. 211, 210-220. crossref(new window)

Bedu-Addo, F. K. and Huang, L. (1995) Interaction of PEGphospholipid conjugates with phospholipid: implications in liposomal drug delivery. Adv. Drug Delivery Rev. 16, 235-247. crossref(new window)

Chang, C. L. and Fogler, H. S. (1997) Controlled Formation of Silica Particles from Tetraethyl Orthosilicate in Nonionic Water-in-Oil Microemulsions. Langmuir. 13, 3295-3307. crossref(new window)

Deasy, P. B. (1984) Microencapsulation and Related Drug Processes. Marcel Dekker Inc; NY, USA.

Deng, X., Liu, Y., and Yuan, M. (2002) Study on biodegradable polymer; Synthesis and charateriztion of poly (DL-lactic acid)-co-poly(ethylene glycol)-co-poly(L-lysine) copolymer. Eur. Polym. J. 38, 1435-1441. crossref(new window)

Dziezak, J. D. (1988) Microencapsulation and encapsulated ingredients. Food Technol. 42, 136-148.

Fanger, G. O. (1974) Microencapsulation: A Brief History and Introduction. In Vandegaer J.E. (Ed.). Microencapsulation- Processes and Applications. Plenum Press, NY, pp. 1-20.

Giese, J. (1993) Packaging, storage and delivery of ingredients. Food Thechnol. 47, 54-63.

Griffin, W. C. (1951) Solid essential oil concentrate and process of preparing the same. U.S. Patent No. 2556410.

Huppertz, T. (2011) Homogenization of Milk; Other Types of Homogenizer (High-Speed Mixing, Ultrasonics, Microfluidizers, Membrane Emulsification). Encyclopedia of Dairy Sciences, 2nd ed., Academinc Press, Elsevier, Amsterdam.

Jackson, L. S. and Lee, K. (1991) Microencapsulated Iron for Food Fortification. J. Food Sci. 56, 1047-1050. crossref(new window)

Kester, J. J. and Fennema, O. R. (1986) Edible films and coatings: a review, Food Thechnol. 40, 47-59.

Lee, M. Y., Min S. G., Bourgeois, S., and Choi, M. J. (2008) Development of a novel nanocapsule formulation by emulsion diffusion combined with high hydrostatic pressure. J. Microencapsul. 26, 122-129.

McGinity, J. W. and O'Donnell, P. B., (1997) Preparation of Microspheres by the solvent evaporation technique. Adv. Drug Del. Rev. 28, 25-42. crossref(new window)

Park, G. Y., Mun, S., Park, Y., Rhee, S., and Decker, E. A. (2007) Influence of encapsulation of emulsified lipids with chitosan on their in vivo digestibility. Food Chem. 104, 761-767. crossref(new window)

Perumal, D. (2001) Microencapsulation of ibuprofen and $Eudragit^{(R)}$ RS 100 by the emulsion solvent diffusion technique. Int. J. Phytorem. 218, 1-11.

Rafati, H., Coombes, A. G. A., Adler, J., Holland ,J., and Davis, S. S. (1997) Protein-loaded poly(DL-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics. J. Control. Release 43, 89-102. crossref(new window)

Risch, S. J. and Reineccius, G. A. (1988) Flavor encapsulation, ACS symposium series No 370, American Chemical Society. Washington DC.

Risch, S. J. and Reineocius, G. A. (1995) Encapsulation and controlled release of food ingredients. ACS symposium series No 590, American Chemical Society. Washington DC.

Ramchandani, M. and Robinson, D. (1998) In vitro and in vivo release of ciprofloxin from PLGA 50:50 implants. J. Control. Release 54, 167-175. crossref(new window)

Shahi, F. S. and Han, X. (1993) Encapsulation of food ingredients. CRC Crit. Rev. Food Sci. Nutr. 33, 501-547. crossref(new window)

Takada, S., Yamagata, Y., Misaki, M., Taira, K., and Kurokawa, T. (2003) Sustained release of human growth hormon from microcapsules prepared by a solvent evaporation technique. J. Control. Release 88, 229-242. crossref(new window)

Taylor, Y. M., Davidson, P. M., Bruce, B. D., and Weiss, J. (2005) Liposomal nanocapsules in food science and agriculture. CRC Crit. Rev. Food. Sci. Nutr. 45, 587-605. crossref(new window)