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Effect of Pig Skin Gelatin Hydrolysates on the Bone Mineral Density of Ovariectomized Rats
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 Title & Authors
Effect of Pig Skin Gelatin Hydrolysates on the Bone Mineral Density of Ovariectomized Rats
Park, Jeong-Eun; Ham, Jun-Sang; Kim, Hey-Kyung; Lee, Chi-Ho; Kim, Dong-Wook; Seol, Kuk-Hwan; Oh, Mi-Hwa; Kim, Dong-Hun; Jang, Ae-Ra;
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This study was conducted to examine the effects of low molecular weight gelatin hydrolysates (GH, less than 3kDa), extracted from pig skin collagen on the bone metabolism of ovariectomized (OVX) rats. The rats in the experimental groups were randomly segregated into six different treatment groups such as 1) NC, the normal rat fed AIN 93 diet (basal diet) only; 2) OC, the OVX rat fed the basal diet only; 3) GH 0.1, the OVX rat fed the basal diet with 0.1% GH; 4) GH 0.8, the OVX rat fed the basal diet with 0.8% GH; 5) G 0.1, the OVX rat fed the basal diet with 0.1% gelatin; 6) G 0.8, the OVX rat fed the basal diet with 0.8% gelatin. Body weight gain in the GH 0.1, GH 0.8, and G 0.8 was significantly higher than those in the NC and OC. Feed intake of the GH 0.1 and GH 0.8 was higher than that of the NC and OC, while no significant difference was found in feed efficiency ratio (FER). BMD of the GH 0.8 was higher than that of the OC. However, gelatin hydrolysates and gelatin resulted in higher BMC level compare to the OC. Serum HDL-cholesterol of rat fed GH and gelatin was higher than that of OC (p<0.05). LDL-C of the GH 0.1 and the GH 0.8 tended to be less than that of OC. Serum alkaline phosphatase (ALP) of the GH 0.1 was lower than that of the OC. The serum of GH 0.8 showed lower osteocalcin value than the OC (p<0.05). In addition, GOT and GPT levels significantly decreased in all treatment groups. These results indicated that gelatin hydrolysates from pig skin gelatin hydrolysates enhanced BMD and serum biochemical parameters related to bone metabolism. Therefore, the gelatin hydrolysates could be used as a beneficial material to improve bone health.
gelatin;collagen;osteoporosis;bone metabolism;pig skin;
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멸치(Engraulis japonicus)젓 잔사 분말칼슘이 난소적출 흰쥐의 골다공증에 미치는 영향,문지영;조은지;주성제;박종훈;윤성호;김만도;김영만;현숙경;임은서;김태훈;손병일;권현주;김병우;이은우;

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