Advanced SearchSearch Tips
Effect of Garcinia cambogia Extract-containing Dip-sauce for Meat on Lipid Accumulation and Body Weight Reduction in Rats Fed High-fat Diet
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effect of Garcinia cambogia Extract-containing Dip-sauce for Meat on Lipid Accumulation and Body Weight Reduction in Rats Fed High-fat Diet
Kang, Eun Sil; Hwang, Jung Seok; Kim, Min-Hwa; Kim, Hye Jung; Lee, Chang-Kwon; Seo, Han Geuk;
  PDF(new window)
Obesity, the leading metabolic disease, is a prevalent health problem in industrialized countries and is closely associated with coronary heart disease, hypertension, diabetes, and even cancer. In this study, we investigated the effects of dip-sauce for meat containing Garcinia cambogia extract (GC) on the lipid accumulation and body weight reduction in rats fed high-fat diet for three months. Eighteen Sprague Dawley male rats of five-week-old were randomly assigned to one of three groups; normal chew diet (NCD) group, high-fat diet plus GC-noncontaining dip-sauce (HFD) group, and HFD plus GC-containing dip-sauce (HFD+GC) group. Co-administration of GC-containing dip-sauce (5 g/kg body weight/day) with HFD significantly attenuated cumulative body weight gain, compared with NCD or HFD groups. Both epididymal and perirenal fat pad weights in the HFD plus GC group were significantly lower than those of HFD or NCD groups. Administration of GC-containing dip-sauce also resulted in significant reduction in the serum levels of total cholesterol, total lipid, and triglyceride, compared with NCD or HFD groups. Thus, GC-containing dip-sauce confers beneficial effects to pathological states associated with metabolic disorder via its anti-obesity and lipid lowering properties.
anti-obesity;Garcinia cambogia;lipid accumulation;high-fat diet;
 Cited by
A comprehensive scientific overview of Garcinia cambogia, Fitoterapia, 2015, 102, 134  crossref(new windwow)
Gatta, B., Zuberbuehler, C., Arnold, M., Aubert, R., Langhans, W., and Chapelot, D. (2009) Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. Br. J. Nutr. 101, 867-1877.

Jena, B. S., Jayaprakasha, G. K., Singh, R. P., and Sakariah, K. K. (2002) Chemistry and biochemistry of (-)-hydroxycitric acid from garcinia. J. Agric. Food Chem. 50, 10-22. crossref(new window)

Kim, S. M., Seo, K. I., Park K. W., Jeong, Y. K., Cho, Y. S., Kim, M. J., Kim, E., and Lee M. K. (2009) Effects of crude saponins from soybean cake on body weight and glucose tolerance in high-fat induced obese mice. J. Korean Soc. Food Sci. Nutr. 38, 39-46. crossref(new window)

Kim, Y. H., Yoo, J. Y., Lee, E. G., Kim, K. B., Jo, D. H., and Hwang, J. Y. (2004) Effects of a dietary supplement consisting of Phaseolus vulgaris and Garcinia cambogia (HCA) on the lipid level and body weight. J. Korean Soc. Food Sci. Nutr. 33, 518-522. crossref(new window)

Kim, Y. J., Jun, H.-S., Park, I. S., Kim, M., Lee, J., Lee, K., and Park, T. (2005) Effect of treadmill exercise training and dietary intake of Garcinia cambogia extract. Soypeptide and L-carnitine mixyure on body weight reduction in rats fed high-fat diet. Korean Nutr. Soc. 38, 626-636.

Korea Food and Drug Administration (KFDA). (2010) Health Functional Food Code. Available from 368&cateIdx=69&categoryCode=18 Accessed Oct. 19, 2010.

Korea Health Industry Development Institute (KHIDI). (2012) KHIDI Brief Vol. 40. Available from 07611485&wj_vcs=. Accessed Sep. 17, 2012.

Korea Restaurant Industry (KRI). (2011) Trend of Food Restaurant Industry. No. 704. Available from§ion=001003&back =I&cat_sel=. Accessed Aug. 12, 2011.

Lee, J. J., Shin, H. D., Lee, Y. M., Kim, A. R., and Lee, M. Y. (2009) Effects of broccoli sprouts on cholesterol-lowering and anti-obesity effects in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 38, 309-318. crossref(new window)

Marquez, F., Babio, N., Bullo, M., and Salas-Salvado, J. (2012) Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit. Rev. Food Sci. Nutr. 52, 585-594. crossref(new window)

Ministry of Health and Welfare (2010) Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Available from http://www. 5771475. Accessed May. 2, 2012.

Park, H. J., Lee, E. J., Kim, J., Kim J. Y., Kwan, O., and Kim, M. K. (2009) Effect of leucine intake on body weight reduction in rats fed high fat diet. Korean J. Nutr. 42, 714-722. crossref(new window)

Park, J. Y. and Kim M. K. (2005) Effects of feeding Garcinia cambogia extract (HCA) and/or L-carnitine and exercise on body weight in rats. Korean J. Nutr. 38, 637-648.

Rícný, J. and Tucek, S. (1982) Acetyl coenzyme A and acetylcholine in slices of rat caudate nuc1eie incubated with (-)-hydroxycitrate, citrate and EGTA. J. Neurochem. 39, 668-673. crossref(new window)

Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J., and Takeuchi, M. (2005) High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obsess rats, but highly toxic to the testis. Food Chem. Toxicol. 43, 411-419. crossref(new window)

Sallis, J. F., Floyd, M. F., Rodríguez, D. A., and Saelens, B. E. (2012) Role of built environments in physical activity, obesity, and cardiovascular disease. Circulation 125, 729-737. crossref(new window)

Soni, M. G., Burdock, G. A., Preuss, H. G., Stohs, S. J., Ohia, S. E., and Bagchi, D. (2004) Safety assessment of (-)-hydroxycitric acid and Super CitriMax‚, a novel calcium/potassium salt. Food Chem. Toxicol. 42, 1513-1529. crossref(new window)

Vander, A., Shennan, J., and Luciano, D. (2001) Human Physiology: The mechanism of body function. 8th ed, McGraw- Hill, NY, pp.572-573.

World Health Organization (2006) Obesity and overweight. Fact sheet No. 311. Available from: http://www.mclveganway. Accessed Sep. 2006.

World Health Organization (2012) Obesity and overweight. Fact sheet No. 311. Available from: factsheets/fs311/en/index. html. Accessed May. 2012.