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Consumption of Water-Soluble Egg Yolk Extract on Growth Rate, Changes in Blood Cholesterol Levels, and Immune Modulation in BALB/c Mice
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 Title & Authors
Consumption of Water-Soluble Egg Yolk Extract on Growth Rate, Changes in Blood Cholesterol Levels, and Immune Modulation in BALB/c Mice
Lee, Won-Young; Lee, Ran; Kim, Hee-Chan; Lee, Kyung-Hoon; Noh, Kyung Sook; Kim, Hyoun Wook; Kim, Ji-Hyuk; Ahn, Dong-Uk; Jang, In-Surk; Jang, Aera; Lee, Hoon-Taek; Song, Hyuk;
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 Abstract
Egg consumption has been limited to avoid cardiovascular diseases such as atherosclerosis and hyperlipidemia, because the yolk contains high levels of cholesterol. This study was conducted to evaluate the effect of the water-soluble component of egg-yolk on the growth efficiency, immune modulation, and changes in serum lipid levels in BALB/c mice. A total 5 wk old 120 BALB/c male mice were divided into 4 groups and were fed 0, 2, 10, and 20 mg/d water-soluble egg yolk extract (WSEYE) for 5 wk. Water-soluble egg yolk extract (WSEYE) uptake resulted in a significant reduction in daily weight gain and feed efficiency rate (FER). The mouse groups treated with 2 and 20 mg/d WSEYE showed a significant increase in populations of monocytes at the third wk and B-lymphocyte activity at the fifth wk. In addition, WSEYE uptake did not influence serum immunoglobulin E levels. In serum lipid-profile studies, treatment of WSEYE did not alter total cholesterol and low-density lipoprotein levels; however, blood triglyceride levels were significantly diminished in mice treated with 2 mg/d at the third wk (p<0.05), and the level of high-density lipoprotein was significantly increased in the mice group treated with 2 and 10 mg/d WSEYE after 5 wk (p<0.05). Taken together, the data demonstrate the beneficial effects of WSEYE in the diet on immune modulation and serum lipid profiles in mouse models; therefore, this study suggests that ingestion of water-soluble fraction of egg yolk might not be related to the increased risk of heart disease, but can be an excellent candidate for maintaining health.
 Keywords
water-soluble egg yolk extract (WSEYE);cholesterol;immunoglobulin;lymphocyte activation;
 Language
English
 Cited by
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2.
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 References
1.
American Heart Association (AHA) (1973) Diet and Coronary Heart Disease. Dallas: American Heart Association.

2.
Ahrens, B., Gruber, G. C., Rha, R. D., Freund, T., Quarcoo, D., Awagyan, A., Hutloff, A., Dittrich, A. M., Wahn, U., and Hamelmann, E. (2009) BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivo. Int. Arch. Allergy. Immunol.150, 210-220. crossref(new window)

3.
Anet, J., Back, J. F., Baker, R. S., Barnett, D., Burley, R. W., and Howden, M. E. (1985) Allergens in the white and yolk of hen's egg. A study of IgE binding by egg proteins. Int. Arch. Allergy Appl. Immunol. 77, 364-371. crossref(new window)

4.
Burrows, B., Martinez, F. D., Halonen, M., Barbee, R. A., and Cline, M. G. (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 320, 271-277. crossref(new window)

5.
Cheong, C., Matos, A., Choi, J. H., Dandamudi, D, B., Shrestha, E., Longhi, M, P., Jeffrey, K, L., Anthony, R, M., Kluger, C., Nchinda, G., Kho, H., Rodriguez, A., Idoyaga, J., Pack, M., Velinzon, K., Park, C, G., and Steinman, R, M. (2010) Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas. Cell 143, 416-429. crossref(new window)

6.
Clarke, R., Frost, C., Collins, R., Appleby, P., and Peto, R. (1997) Dietary lipids and blood cholesterol: Quantitative meta-analysis of metabolic ward studies. Brit. Med. J. 314, 112-117. crossref(new window)

7.
Coombs, R. R. and McLaughlan, P. (1984) Allergenicity of food proteins and its possible modification. Ann. Allergy 53, 592-596.

8.
Eckhardt, E. R., Wang, D. Q., Donovan, J. M., and Carey, M. C. (2002) Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers. Gastroenterol. 122, 948-956. crossref(new window)

9.
Farrelly, C. O., Branton, D., and Wanke, C. A. (1992) Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain. Infect. Immun. 60, 2593-2597

10.
Heine, R. G., Laske, N., and Hill, D. J. (2006) The diagnosis and management of egg allergy. Curr. Allergy Asthma. Rep. 6, 145-152 crossref(new window)

11.
Howell, W. H., McNamara, D. J., Tosca, M. A., Smith, B. T., and Gaines, J. A. (1997) Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis. Am. J. Clin. Nutr. 65, 1747-1764.

12.
Hu, F. B., Stampfer, M. J., Rimm, E. B., Manson, J. E., Ascherio, A., Colditz, G. A., Rosner, B. A., Spiegelman, D., Speizer, F. E., Sacks, F. M., Hennekens, C. H., and Willett, W. C. (1999) A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 281, 1387-1394. crossref(new window)

13.
Ikemori, Y., Kuroki, M., Peralta, R. C., Yokoyama, H., and Kodama, Y. (1992) Protection of neonatal calves against fetal enteric colibacillosis by administration of egg yolk powder from hens immunized with k99-piliated enterotoxigenic Escherichia coli. Am. J. Vet. Res. 53, 2005-2008.

14.
Jang, A., Kim, D. W., Park, J. E., Choe, J. H., Kang, K. H., Ham, J. S., Oh, M. H., Seol, K. H., Lee, S. K., Kim, D. H., Kim, H. W., Hwang, K. H., Hwang, Y. J., and Kim H. K. (2011) Effect of hen egg supplementation on blood lipid profile and fecal bile acid of C57BL/6 mouse fed normal and high cholesterol diet. Korean J. Food. Sci. An. 31, 250-256. crossref(new window)

15.
Jiang, Y., Noh, S. K., and Koo, S. I. (2001) Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats. J. Nutr. 131, 2358-2363.

16.
Kim, I. H., Lee, Y. T., Lee, C. H., and Chung, B. H. (1999) Purification of egg immunoglobulin IgY. Korean J. Biotechnol. Bioeng. 14, 677-981.

17.
Kritchevsky, S.B. and Kritchevsky, D. (2000) Egg consumption and coronary heart disease: An Epidemiologic Overview. J. Am. Coll.Nutr. 19, 549-555. crossref(new window)

18.
Kritchevsky, S.B. (2004) A review of scientific research and recommendation regarding eggs. J. Am. Coll.Nutr. 23, 596-600. crossref(new window)

19.
Krumholz, H. M., Seeman, T. E., Merrill, S. S., Mendes de Leon, C. F., Vaccarino, V., Silverman, D. I., Tsukahara, R., Ostfeld, A. M., and Berkman, L. F. (1994) Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 272, 1335-1340. crossref(new window)

20.
Li, X., Su, Y., Sun, J., and Yang, Y. (2012) Chicken embryo extracts enhance spleen lymphocyte and peritoneal macrophages function. J. Ethnophamacol. 144, 255-260. crossref(new window)

21.
McNamara, D. J. (2000) The impact of egg limitations on coronary heart disease risk: do the numbers add up? J. Am. Coll. Nutr. 19, 540S-548S. crossref(new window)

22.
Moussion, C. and Girard, J, P. (2011) Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479, 542-546. crossref(new window)

23.
Nagaoka, S., Masaoka, M., Zhang, Q., Hasegawa, M., and Watanabe, K. (2002) Egg ovomucin attenuates hypercholesterolemia in rats and inhibits cholesterol absorption in Caco2 cells. Lipids 37, 267-272. crossref(new window)

24.
Niggemann, B., Sielaff, B., Beyer, K., Binder, C., and Wahn, U. (1999) Outcome of double-bind, placebo-controlled food challenge tests in 107 children with atopic dermatitis. Clin. Exp. Allergy 29, 91-96. crossref(new window)

25.
Noh, S. K. and Koo, S. I. (2003) Egg sphingomyelin lowers the lymphatic absorption of cholesterol and alpha-tocopherol in rats. J. Nutr. 133, 3571-3576.

26.
Sampson, H. A. (2004) Update on food allergy. J. Allergy Clin. Immunol. 113, 805-819. crossref(new window)

27.
Seo, J. H., Lee, J. W., Lee, Y. S., Lee,S. Y., Kim, M. R., Yook, H. S., and Byun, M. W. (2004) Change of an egg allergen in a white layer cake containing gamma irradiated egg white. J. Food. Prot.6 7, 1725-1730.

28.
Song, W.O. and Kerver, J. M. (2000) Nutritional contribution of eggs to American diets. J. Am. Coll. Nutr. 19, 556-562. crossref(new window)

29.
Stamler, J. and Shekelle, R. (1998) Dietary cholesterol and human coronary heart disease. Arch. Pathol. Lab. Med. 112, 1032-1040.

30.
Sunwoo, H. H., Lee, E. N., Gujral, N., and Suresh, M. R. (2010) Growth inhibition of Escherichia coli 987P by neutralizing IgY antibodies. Open Immunol. J. 3. 1-8 crossref(new window)

31.
Szepfalusi, Z., Ebner, C., Pandjaitan, R., Orlicek, F., Scheiner, O., Boltz-Nitulescu, G., Kraft, D., and Ebner, H. (1994) Egg yolk alpha-livetin (chicken serum albumin) is a cross-reactive allergen in the bird-egg syndrome. J. Allergy Clin. Immunol. 93, 932-942. crossref(new window)

32.
Van der Wal, J. S., Marth, J. M., Khosla, P., Jen, K. L., and Dhurandhar, N. V. (2005) Short-term effect of eggs on satiety in overweight and obese subjects. J. Am. Coll. Nutr. 24, 510-515. crossref(new window)

33.
Van der Plancken, I., Delattre, M., Indrawati, I., Van Loey, A., and Hendrickx, M. E. (2004) Kinetic study on the changes in the susceptibility of egg white proteins to enzymatic hydrolysis induced by heat and high hydrostatic pressure pretreatment. J. Agric. Food. Chem.52, 5621-5626. crossref(new window)

34.
Wallach, M. G., Webby, R. J., Islam, F., Walkden-Brown, S., Emmoth, E., Feinstein, R., and Gronvik, K. O. (2011) Cross-protection of chicken immunoglobulin Y antibodies against H5N1 and H1N1 viruses passively administered in mice. Clin. Vaccine Immunol. 18, 1083-1090. crossref(new window)

35.
Walsh, B. J., Barnett, D., Burley, R. W., Elliott, C., Hill, D. J., and Howden, M. E. H. (1988) New allergens from hen's egg white and egg yolk. Int. Arch. Allergy Immunol. 87, 81-86. crossref(new window)