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The Preventive Effects of Nanopowdered Peanut Sprout-added Caciocavallo Cheese on Collagen-induced Arthritic Mice
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 Title & Authors
The Preventive Effects of Nanopowdered Peanut Sprout-added Caciocavallo Cheese on Collagen-induced Arthritic Mice
Kim, Dong-Hwi; Chang, Yoon Hyuk; Kwak, Hae-Soo;
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The present study was carried out to investigate the effects of nanopowdered peanut sprout-added Caciocavallo cheese (NPCC) on the prevention and treatment of rheumatoid arthritis in DBA/IJ mice immunized with type II collagen. After the induction of arthritis, the mice were being divided into five groups: (1) normal, no immunization; (2) CIA, collagen-induced arthritis; (3) MTX, collagen-induced arthritis treated with methotrexate (0.3 mg/kg body weight); (4) CC, collagen-induced arthritis treated with Caciocavallo cheese (0.6 g/d); (5) NPCC, collagen-induced arthritis treated with nanopowdered peanut sprout-added Caciocavallo cheese (0.6 g/d). Nanopowdered peanut sprout was ranged from 300 to 350 nm, while regular powdered peanut sprouts were ranged from 50 to . The NPCC group had considerable reductions of clinical scores and paw thicknesses at the end of experiment as compared to the CIA group. In the serum analysis, the TNF-, IL-, IL-6 and levels in the NPCC group have decreased by 69.4, 75.9, 66.6, and 61.9%, respectively, when compared to the CIA group. The histological score and spleen index of the NPCC group were significantly lower than the CIA group. In conclusion, the feeding NPCC method could delay and/or prevent the rheumatoid arthritis in the collagen-induced arthritis mouse model. Based on this study, nanopowdered peanut sprouts could be applied to various functional cheeses.
rheumatoid arthritis;nanopowdered peanut sprout;Caciocavallo cheese;
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Physicochemical and microbial properties of nanopowdered peanut sprout-supplemented Caciocavallo-like cheese during ripening, International Journal of Dairy Technology, 2017, 70, 1, 84  crossref(new windwow)
Recent trends of nano bioactive compounds from ginseng for its possible preventive role in chronic disease models, RSC Adv., 2015, 5, 119, 98634  crossref(new windwow)
Ahn, Y. J., Palanivel, G., and Kwak, H. S. (2012) Comparison of nanopowdered and powdered peanut sprout-added yogurt on its physicochemical and sensory properties during storage. Korean. J. Food Sci. An. 5, 553-560. crossref(new window)

American Institute of Nutrition. (1977) Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies. J. Nutr. 107, 1340-1348.

Borchers, A. T., Keen, C. L., Cheema, G. S., and Gershwin, M. E. (2004) Theuse of methotrexate in rheumatoid arthritis. Semin. Arthritis Rheum. 34, 465-483. crossref(new window)

Brand, D. D., Latham, K. A., and Rosloniec, E. F. (2007) Collagen- induced arthritis. Nat. Protoc.2, 1269-1275. crossref(new window)

Burns, J., Yokota, T., Ashihara, H., Lean, M. E., and Crozier, A. (2002) Plant foods and herbal sources of resveratrol. Food Chem. 50, 3337-3340. crossref(new window)

Chunxia, C., Peng, Z., Huifang, P., Hanli, R., Zehua, H., and Jizhou, W. (2011) Extracts of Arisaemarhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice. J. Ethnopharmacol. 133, 573-582. crossref(new window)

Elmali, N., Baysal, O., Harma, A., Esenkaya, I., and Mizrak, B. (2006) Effects of resveratrol in inflammatory arthritis. Inflammation 30, 1-2.

Feldmann, M., Brennan, F. M., and Maini, R. N. (1996) Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440. crossref(new window)

Gobbetti, M., Morea, M., Baruzzi, F., Corbo, M. R., Matarante, A., Considine, T., Cagno, R. D., Guinee, T., and Fox, P. F. (2002) Microbiological, compositional, biochemical and textural characterisation of Caciocavallo Pugliese cheese during ripening. Int. Dairy J. 12, 511-523. crossref(new window)

Goldring, S. R. (2003) Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford).42, 11-16. crossref(new window)

Hongfang, W. and Meng, Z. (2011) Immune function changes of rats in recremental graded exercise test. Afr. J. Microbiol. Res. 5, 1557-1561.

Lee, Y. K., Ahn, S. I., and Kwak, H. S. (2013) Optimizing microencapsulation of peanut sprout extract by response surface methodology. Food Hydrocolloid.30, 307-314. crossref(new window)

Maini, R. N. and Taylor, P. C. (2000) Anti-cytokine therapy for rheumatoid arthritis. Annu. Rev. Med. 51, 207-229. crossref(new window)

Mankin, H. J., Dorfman, H., Lippiello, L., and Zarins, A. (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J. Bone Joint Surg. Am. 53, 523-537.

Park, H. S., Jeon, B. J., Ahn, J., and Kwak, H. S. (2007) Effects of nanocalcium supplemented milk on bone calcium metabolism in ovariectomized rats. Asian Austral. J. Anim. 20, 1266-1271. crossref(new window)

Rasenack, N. and Muller, B. W. (2004) Micron-size drug particles: Common and novel micronization techniques. Pharm. Dev. Technol. 9, 1-13. crossref(new window)

Sánchez-Fidalgo, S., Cárdeno, A., Villegas, I., Talero, E., and de la Lastra, C. A. (2010) Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice. Eur. J. Pharmacol. 633, 78-84. crossref(new window)

Stamp, L. K., James, M. J., and Cleland, L. G. (2005) Diet and rheumatoid arthritis: A Review of the literature. Semin. Arthritis Rheu. 35, 77-94. crossref(new window)

Seo, M. H., Lee, S. Y., Chang, Y. H., and Kwak, H. S. (2009) Physicochemical, microbial and sensory properties of yogurt supplemented with nanopowdered chitosan during storage. J. Dairy Sci. 92, 5907-5916. crossref(new window)

Smolen, J. S. and Steiner, G. (2004) Therapeutic strategies for rheumatoid arthritis. New Engl. J. Med. 350, 591-602.

Wang, K. H., Lai, Y. H., Chang, J. C., Ko, S. L., and Chiou, R. Y. (2005) Germination of peanut kernels to enhance resveratrol biosynthesis and prepare sprout as a functional vegetable. J. Agr Food Chem. 53, 242-246. crossref(new window)

Xiong, Q. P., Zhang, Q. H., Zhang, D. Y., Shi, Y. Y., Jiang, C. X., and Shi, X. J. (2014) Preliminary separation and purification of resveratrol from extract of peanut (Arachishypogaea) sprouts by macroporous adsorption resins. Food Chem. 145, 1-7. crossref(new window)

Xuzhu, G., Komai-Koma, M., Leung, B. P., Howe, H. S., Mc- Sharry, C., Mclnnes, I. B., and Xu, D. (2012) Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann. Rheum. Dis. 71, 129-135. crossref(new window)

Viji, V., Kavitha, S. K., and Helen, A. (2010) Bacopamonniera (L.) wettst inhibits type ii collagen-induced arthritis in rats. Phytother. Res. 9, 1377-1383.