JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Anti-obesity Effect of Fermented Whey Beverage using Lactic Acid Bacteria in Diet-induced Obese Rats
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Anti-obesity Effect of Fermented Whey Beverage using Lactic Acid Bacteria in Diet-induced Obese Rats
Hong, Sung-Moon; Chung, Eui-Chun; Kim, Cheol-Hyun;
  PDF(new window)
 Abstract
High-protein fermented whey beverage (FWB) was manufactured using whey protein concentrate (WPC) and Lactobacillus plantarum DK211 isolated from kimchi. This study was designed to evaluate the anti-obesity activity of FWB in male rats fed a high-fat diet. Male Sprague-Dawley rats were randomly assigned to three groups (n=8 per group). The three groups differed in their diet; one group received a normal diet (ND), another, a high-fat diet (HD), and the third, a HD plus fermented whey beverage (HDFWB), for 4 wk. Supplementation with FWB (the HDFWB group) prevented weight gain and body fat accumulation. The food intake in the HDWFB group was significantly lower (p<0.05) than that of the HD group. The HDWFB group also showed a significant decrease in organ weights (p<0.05), except for the weight of the testis. There was a significant decrease in total cholesterol, LDL-cholesterol, and triglycerides in the HDFWB group compared with the HD group (p<0.05), but there was no significant difference in serum HDL-cholesterol levels among the experimental groups. Rats ingesting FWB (the HDFWB group) also showed a significant decrease in blood glucose levels, and plasma levels of insulin, leptin, and ghrelin compared to HD group (p<0.05). These results indicate that FWB has beneficial effects on dietary control, weight control, and reduction in fat composition and serum lipid level; consequently, it may provide antiobesity and hypolipidemic activity against high fat diet-induced obesity in rats.
 Keywords
whey protein;obesity;Lactobacillus plantarum;cholesterol;leptin;
 Language
English
 Cited by
 References
1.
Bais, S., Singh, G. S., and Sharma, R. (2014) Antiobisity and hypolipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Adv. Biol. Article ID 162914.

2.
Belobrajdic, D. P., Mclntosh, G. H., and Owens, J. A. (2004) A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in Wistar rats. J. Nutr. 134, 1454-1458.

3.
Bocarsly, M. E., Powell, E. S., Avena, N. M., and Hoebel, B. G. (2010) High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels. Pharmacol. Biochem. Behav. 97, 101-106. crossref(new window)

4.
Cho, Y. H., Shin, I. S., Hong, S. M., and Kim, C. H. (2015) Production of functional high-protein beverage fermented with Lactic acid bacteria isolated from Korean traditional fermented food. Korean J. Food Sci. An. 35, (In press).

5.
Douglas, S. M., Ortinau, L. C., Hoertel, H. A., and Leidy, H. J. (2013) Low, moderate, or high protein yogurt snacks on appetite control and subsequent eating in healthy woman. Appetite 60, 117-122. crossref(new window)

6.
Fan, S., Zhang, Y., Sun, Q., Yu, L., Li, M., Zheng, B., Wu, W., Yang, B., Li, Y., and Huang, C. (2014) Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice. J. Nutr. Biochem. 25, 702-709. crossref(new window)

7.
Fradinho, M. J., Correia, M. J., Gracio, V., Bliebernicht, M.,Farrim, A., Mateus, L., Martin-Rosset, W., Bessa, R. J. B., and Caldeira, R. M. (2014) Effects of body condition and leptin on the reproductive performance of Lusitano mares on extensivesystems. Theriogenology 81, 1214-1222. crossref(new window)

8.
Ikeda, T., Tanaka, Y., Yamamoto, K., Morii, H., Kamisako, T., and Ogawa, H. (2014) Geranium dielsianum extract powder(MISKAMISKATM) improves the intestinal environment through alteration of microbiota and microbial metabolites in rats. J. Funct. Foods 11, 12-19. crossref(new window)

9.
Jacobucci, H. B., Sgarbieri, V. C., Dias, N. F. G. P., Borges, P., and Tanikawa, C. (2001) Impact of different dietary protein on rat growth, blood serum lipids and protein and liver cholesterol. Nutr. Res. 21, 905-915. crossref(new window)

10.
Jakubowicz, D. and Froy, O. (2013) Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes. J. Nutr. Biochem. 24, 1-5. crossref(new window)

11.
Jin, D., Xu, Y., Mei, X., Meng, Q., Gao, Y., Li, B., and Tu, Y. (2013) Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats. J. Funct. Foods 5, 1142-1150. crossref(new window)

12.
Klok, M., Jakobsdottir, S., and Drent, M. L. (2007) The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review. Obes. Rev. 8, 21-34. crossref(new window)

13.
Kondoh, T. and Torii, K. (2008) MSG intake suppresses weight gain, fat deposition, and plasma leptin levels in male Sprague-Dawley rats. Physiol. Behav. 95, 135-144. crossref(new window)

14.
Lee, B. H., Lo, Y. H., and Pan, T. M. (2013) Anti-obesity activity of Lactobacillus fermented soy milk products. J. Funct. Foods 5, 905-913. crossref(new window)

15.
Martinez-Gonzalez, M. A., Sayon-Orea, C., Ruiz-Canela, M., de la Fuente, C., Gea, A., and Bes-Rastrollo, M. (2014) Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study. Nutr. Metab. Cardiovasc. Dis. 24, 1189-1196. crossref(new window)

16.
Pal, S., Ellis, V., and Dhaliwal, S. (2010) Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br. J. Nutr. 104, 716-723. crossref(new window)

17.
Park, J. Y., Park, M. N., Choi, Y. Y., Yun, S. S., Chun, H. N.,and Lee, Y. S. (2008) Effects of whey protein hydrolysates on lipid profiles and appetite-related hormones in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 37, 428-436. crossref(new window)

18.
Pilvi, T. K., Seppanen-Laakso, T., Simolin, H., Finckenberg, P., Huotari, A., Herzig, K. H., Korpela, R., Oresic, M., and Mervaala, E. M. (2008) Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction. World J. Gastroenterol. 14, 4462-4472. crossref(new window)

19.
Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J., Kearney, S. M., Chatzigiagkos, A., Hafler, D. A., Alm, E.J., and Erdman, S. E. (2013) Microbial reprogramming inhibits western diet associated obesity. PLoS One 8, e68596. crossref(new window)

20.
Rittmanic, S. (2008) U.S. whey proteins in ready-to-drink beverages. US Dairy Export. Council.

21.
Sanmartin, B., Diaz, O., Rodriguez-Turienzo, L., and Cobos, A. (2013) Functional properties of caprine whey protein concentrates obtained from clarified cheese whey. Small Ruminant Res. 110, 52-56. crossref(new window)

22.
Shi, J., Ahlroos-Lehmus, A., Pilvi, T. K., Korpela, R., Tossavainen, O., and Mervaala, E. M. (2012) Metabolic effects of a novel microfiltered native whey protein in diet-induced obese mice. J. Funct. Foods 4, 440-449. crossref(new window)

23.
Shi, J., Tauriainen, E., Martonen, E., Finckenberg, P., Ahlroos-Lehmus, A., Tuomainen, A., Pilvi, T. K., Korpela, R., and Mervaala, E. M. (2011) Whey protein isolate protects against diet-induced obesity and fatty liver formation. Int. Dairy J. 21, 513-522. crossref(new window)

24.
Siddiqui, S. M. K., Chang, E., Li, J., Burlage, C., Zou, M., Buhman, K. K., Koser, S., Donkin, S. S., and Teegarden, D. (2008) Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. Nutr. Res. 28, 783-790. crossref(new window)

25.
Sim, Y. B., Park, S. H., Kim, S. S., Kim, C. H., Kim, S. J., Lim, S. M., Jung, J. S., and Suh, H. W. (2014) Ghrelin administered spinally increases the blood glucose level in mice. Peptides 54, 162-165. crossref(new window)

26.
You, J. S., Lee, Y. J., Kim, K. S., Kim, S. H., and Chang, K. J. (2014) Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Nutr. Res. 34, 258-267. crossref(new window)

27.
Yu, Y., South, T., and Huang, X. U. (2009) Inter-meal interval is increased in mice fed a high whey, as opposed to soy and gluten, protein diets. Appetite 52, 372-379. crossref(new window)

28.
Xu, S. P., Mao, X. Y., Cheng, X., and Chen, B. (2013) Ameliorating effects of casein glycomacropeptide on obesity induced by high-fat diet in male Sprague-Dawley rats. Food Chem. Toxicol. 56, 1-7. crossref(new window)