Advanced SearchSearch Tips
Bioactive Peptides in Milk and Dairy Products: A Review
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Bioactive Peptides in Milk and Dairy Products: A Review
Park, Young Woo; Nam, Myoung Soo;
  PDF(new window)
Functionally and physiologically active peptides are produced from several food proteins during gastrointestinal digestion and fermentation of food materials with lactic acid bacteria. Once bioactive peptides (BPs) are liberated, they exhibit a wide variety of physiological functions in the human body such as gastrointestinal, cardiovascular, immune, endocrine, and nervous systems. These functionalities of the peptides in human health and physiology include antihypertensive, antimicrobial, antioxidative, antithrombotic, opioid, anti-appetizing, immunomodulatory and mineral-binding activities.
bioactive peptide;milk;proteins;functional foods;human health;
 Cited by
Characterization of soy protein hydrolysates produced by varying subcritical water processing temperature, Innovative Food Science & Emerging Technologies, 2017, 43, 201  crossref(new windwow)
Proteomics applied to pediatric medicine: opportunities and challenges, Expert Review of Proteomics, 2016, 13, 9, 883  crossref(new windwow)
Comparison of the bioactivity of whole and skimmed digested sheep milk with that of digested goat and cow milk in functional cell culture assays, Small Ruminant Research, 2017, 149, 202  crossref(new windwow)
Identification of Novel Cytotoxic Peptide KENPVLSLVNGMF from Marine Sponge Xestospongia testudinaria, with Characterization of Stability in Human Serum, International Journal of Peptide Research and Therapeutics, 2017  crossref(new windwow)
Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects, Beverages, 2017, 3, 3, 41  crossref(new windwow)
Mechanisms of Expression and Release of Endogenous Opioids in Peripheral Tissues, Neurophysiology, 2016, 48, 3, 205  crossref(new windwow)
Lactational challenges in transition dairy cows, Animal Production Science, 2017, 57, 7, 1471  crossref(new windwow)
Immunomodulation by hydrolysates and peptides derived from milk proteins, International Journal of Dairy Technology, 2017  crossref(new windwow)
Whey protein as a key component in food systems: Physicochemical properties, production technologies and applications, Food Structure, 2017  crossref(new windwow)
Ohmic heating in dairy processing: Relevant aspects for safety and quality, Trends in Food Science & Technology, 2017, 62, 104  crossref(new windwow)
Ratio of dietary rumen degradable protein to rumen undegradable protein affects nitrogen partitioning but does not affect the bovine milk proteome produced by mid-lactation Holstein dairy cows, Journal of Dairy Science, 2017, 100, 9, 7246  crossref(new windwow)
Prospects in the use of aptamers for characterizing the structure and stability of bioactive proteins and peptides in food, Analytical and Bioanalytical Chemistry, 2017  crossref(new windwow)
Bioactive peptides: A review, Food Quality and Safety, 2017, 1, 1, 29  crossref(new windwow)
Principles of pharmacological research of nutraceuticals, British Journal of Pharmacology, 2017, 174, 11, 1177  crossref(new windwow)
Specificity of peptidases secreted by filamentous fungi, Bioengineered, 2017, 1  crossref(new windwow)
Development of thermally processed bioactive pea protein gels: Evaluation of mechanical and antioxidant properties, Food and Bioproducts Processing, 2017, 101, 74  crossref(new windwow)
Unusual Listeria monocytogenes peritonitis in peritoneal dialysis patient with liver cirrhosis: a case report and review of literature, CEN Case Reports, 2017, 6, 1, 115  crossref(new windwow)
Bezkorovainy, A., Grohlich, D., and Nichols, J. H. (1979) Isolation of a glycopeptide fraction with Lactobacillus bifidus subspecies Pennsylvanicus growth-promoting activity from whole human milk casein. Am. J. Clin. Nutr. 32, 1428-1432.

Bezkorovainy, A. and Topouzian, N. (1981) Bifidobacteriumbifidus var. Pennsylvanicus growth promoting activity of human milk casein and its derivatives. Int. J. Biochem. 13, 585-590. crossref(new window)

Bounous, G. and Gold, P. (1991) The biological activity of undenatured dietary whey proteins: Role of glutathione. Clin. Invest. Med. 14, 296-309.

Brown, K. D. and Blakeley, D. M. (1984) Partial purification and characterization of a growth factor present in goat’s colostrum. Biochem. J. 219, 609-617. crossref(new window)

Byun, H.-G., Lee, J. K., Park, H. G., Jeon, J.-K., and Kim, S.-K. (2009) Antioxidant peptides isolated from the marine rotifer, Brachionus rotundiformis. Process Biochem. 44, 842-846. crossref(new window)

Calder, P. C. (1994) Glutamine and the immune system. Clin. Nutr. 13, 2-8.

Chabance, B., Marteau, P., Rambaud, J. C., Migliore-Samour, D., Jolles, P., Boynard, M., Perrotin, P., Buillet, R., and Fiat, A. M. (1998) Casein peptided release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 80, 155-165. crossref(new window)

Clare, D. A., Catignani, G. L., and Swaisgood, H. E. (2003) Biodefense properties of milk: the role of antimicrobial proteins and peptides. Curr. Pharm. Des. 9, 1239-1255. crossref(new window)

Clare, D. A. and Swaisgood, H. E. (2000) Bioactive milk peptides: A prospectus. J. Dairy Sci. 83, 1187-1195. crossref(new window)

Denhard, M., Claus, R., Munz, O., and Weiler, U. (2000) Course of epidermal growth factor (EGF) and insulin-like growth factor (IFG-I) in mammary secretions of the goat during endpregnancy and early lactation. J. Vet. Med. Ser. A 47, 533-540. crossref(new window)

Eliassen, L. T., Berge, G., Sveinbjornsson, B., Svendsen, J. S., Vorland, L. H., and Rekdal, O. (2002) Evidence for a direct antitumor mechanism of action of Bovine lactoferricin. Anticancer Res. 22, 2703-2710.

Elitsur, Y. and Luk, G. D. (1991) β-casomorphin (BCM) and human colonic lamina proprialymphocyte proliferation. Clin. Exp. Immunol. 85, 493-497.

Fiat, A. M., Miglilore-Samour, D., Jolles, P., Crouet, L., Collier, C., and Caen, J. (1993) Biologicallyactive peptides from milk proteins with emphasis on two example concerning antithrombotic and immuno-modulating activities. J. Dairy Sci. 76, 301-310. crossref(new window)

FitzGerald, R. J. and Meisel, H. (2000) Milk protein derived peptide inhibitors of angiotensin-I converting enzyme. Brit. J. Nutr. 84, S33-S37.

FitzGerald R. J. and Meisel, H. (2003) Milk protein hydrolysates and bioactive peptides. In: Advances in Dairy Chemistry. Fox, P. F. and McSweeney, P. L. H. 3rd ed, Kluwer Academic/Plenum Publishers, NY, pp. 675-698.

FitzGerald, R. J., Murray, B. A., and Walsh, D. J. (2004) Hypotensive peptides from milk proteins. J. Nutr. 134, 980S-988S.

Gill, H. S., Coull, F., Rutherfurd, K. J., and Cross, M. L. (2000) Immunoregulatory peptides in bovine milk. Br. J. Nutr. 84, S111-S117.

Gobbetti, M., Minervini, F., and Rizzello, C. G. (2004) Angiotensin I-converting enzyme inhibitory and antimicrobial bioactive peptides. Int. J. Dairy Technol. 57, 173-188. crossref(new window)

Gobbetti, M., Minervini, F., and Rizzello, C. G. (2007) Bioactive peptides in dairy products. In: Handbook of food products manufacturing. Y. H. Hui, (ed), John Wiley & Sons, Inc. pp. 489-517.

Goldman, A. S. and Goldblum, R. M. (1995) Defense agents in milk: A defense agents in human milk. In: Handbook of Milk Composition. Jensen, R. (ed) Academic Press, NY, pp. 727-748.

Grosvenor, C. E., Picciano, M. F., and Baumrucker, C. R. (1992) Hormones and growth factors in milk. Endocr. Rev. 14, 710-728.

Gyorgy, P., Jeanloz, R. W., Von Nicolai, H., and Zilliken, F. (1974) Undialyzable growth factors for Lactobacillus bifidus var. Pennsylvanicus. Eur. J. Biochem. 43, 29-33. crossref(new window)

Haenlein, G. F. W. and Caccese, R. (1984) Goat milk versus cow milk. In: Extension Goat Handbook. Haenlein, G. F. W. and Ace, D. L. (ed) USDA Publication, Washington, D.C., E-1: pp. 1-4.

Hartmann, R., Gunther, S., Martin, D., Meisel, H., Pentzien, A. K., Schlimme, E., and Scholz. N. (2000) Cytochemical model systems for the detection and characterization of potentially bioactive milk components. Kieler Milchwirtschaftliche Forschungsberichte 52, 61-85.

Hartmann, R. and Meisel, H. (2007) Food-derivedpeptides with biological activity: from research to food applications. Curr. Opin. Biotech. 18, 1-7. crossref(new window)

Hill, R. D., Lahov, E., and Givol, D. (1974) A rennin-sensitive bond in alpha and beta casein. J. Dairy Res. 41, 147-153. crossref(new window)

Hutchens, T. W., Rumball, S. V., and Lonnerdal, B. (1994) Lactoferrin: structure and function. Adv. Exp. Med. Biol. 357, 1-298. crossref(new window)

Iwami, K., Sakakibara, K., and Ibuki, F. (1986) Involvement of post-digestion hydrophobic peptides in plasma cholesterol-lowering effect of dietary plant protein. Agri. Bio. Chem. 50, 1217-1222. crossref(new window)

Jolles, P., Levy-Toledano, S., Fiat, A. M., Soria, C., Gillesen, D., Thomaidis, A., Dunn, F. W., and Caen, J. (1986) Analogy between fibrinogen and casein: effect of an undecapeptide isolated from k-casein on platelet function. Eur. J. Biochem. 158, 379-382. crossref(new window)

Jones, F. S. and Simms, H. S. (1930) The bacterial growth inhibitor (lactenin) of milk. J. Exp. Med. 51, 327-339. crossref(new window)

Kitts, D. D. and Weiler, K. (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr. Pharm. Des. 9, 1309-1323. crossref(new window)

Korhonen, H. and Marnila, P. (2006) Bovine milk antibodies for protection against microbial human diseases. In: Nutraceutical Proteins and Peptides in Health and Disease. Mine, Y. and Shahidi, S. (ed) Taylor & Francis Group, Boca Raton, F. L., USA. pp. 137-159.

Korhonen, H. and Pihlanto-Leppala, A. (2004) Milk-derived bioactive peptides: formation and prospects for health promotion. In: Handbook of Functional Dairy Products. C. Shortt and J. O’Brien eds. CRC Press. Boca Raton, F. L., USA. pp. 109-124.

Korhonen, H., Pihlanto-Leppala, A., Rantamaki, P., and Tupasela, T. (1998) The functional and biological properties of whey proteins: prospects for the development of functional foods. Agri. Food Sci. Finland 7, 283-296.

Korhonen, H. and Pihlanto, A. (2007a) Food-derived bioactive peptides - opportunities for designing future foods. Curr. Pharm. Des. 9, 1297-1308.

Korhonen, H. and Pihlanto, A. (2007b) Bioactive peptides from food proteins. In: Handbook of food products manufacturing. Hui, Y. H. (ed) John Wiley & Sons, Inc., pp. 5-37.

Korhonen, H. and Pihlanto-Leppala, A. (2004) Milk-derived bioactive peptides: Formation and prospects for health promotion. In: Handbook of functional dairy products. Shortt, C. and O’Brien, J. (ed) CRC Press, Boca Raton, F. L., USA. pp. 109-124.

Krissansen, G. W. (2007) Emerging health properties of whey proteins and their clinical implications. J. Amer. College Nutr. 26, 713S-723S. crossref(new window)

Li, G., Le, G., Shi, Y., and Shrestha, S. (2004) Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr. Res. 24, 469-486. crossref(new window)

Matar, C., LeBlanc, J. G., Martin, L., and Perdigon, G. (2003) Active peptides released in fermented milk: role and functions. Handbook of Fermented Functional Foods. Functional Foods and Nutraceuticals series. In: Farnworth ER, (ed) CRC Press. Boca Raton, F. L., USA, pp. 177-201.

Meisel, H. (1998) Overview on milk protein-derived peptides. Inter. Dairy J. 8, 363-373. crossref(new window)

Meisel, H. and FitzGerald, R. J. (2000) Opioid peptides encrypted in intact milk protein sequences. Br. J. Nutr. 84, 27-31.

Meisel, H. and FitzGerald, R. J. (2003) Biofunctional peptides From milk proteins: mineral binding andcytomodulatory effects. Curr. Pharm. Des. 9, 1289-1295. crossref(new window)

Meisel, H. and Olieman, C. (1998) Estimation of calcium-binding constants of casein phosphopeptides by capillary zone electrophoresis. Analytica Chimica Acta 372, 291-297. crossref(new window)

Meisel, H. and Schlimme, E. (1994) Inhibitors of angiotensin-converting enzyme derived from bovine casein (casokinins). In: Brantl, V., Teschemacher, H., editors, κ-casomorphins and related peptides: recent developments. Weinheim: VCH. pp. 27-33.

Meisel, H. and Schlimme, E. (1996) Bioacive peptides derived from milk proteins: ingredients for functional foods. Kieler Milchwirtschaftliche Forschungsberichte 48, 343-357.

Nagaoka, S., Futamura, Y., Miwa, K., Takako, A., Yamauchi, K., Kanamaru, Y., Tadashi, K., and Kuwata, T. (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem. Biophys Res. Commun. 281, 11-17. crossref(new window)

Park, Y. W. (1990) Nutrient profiles of commercial goat milk cheeses manufactured in the United States. J. Dairy Sci. 73, 3059-3067. crossref(new window)

Park, Y. W. (2006) Goat milk - Chemistry and Nutrition. In: Handbook of Milk of Non-Bovine Mammals. Y. W. Park and G. F. W. Haenlein, (ed) Blackwell Publishers. Ames, Iowa and Oxford, England. pp. 34-58.

Park, Y. W. (2009a) Bioactive components of goat milk. In: Bioactive Components in Milk and Dairy Products. Y. W. Park, (ed) Wiley-Blackwell Publishers, Ames, Iowa and Oxford, England. pp. 43-82.

Park, Y. W. (2009b) Overview of bioactive components in milk and dairy products. In: Bioactive Components in Milk and Dairy Products. Park, Y. W. (ed) Wiley-Blackwell Publishers, Ames, Iowa and Oxford, England. pp. 3-14.

Park, Y. W., Juárez, M., Ramos, M., and Haenlein, G. F. W. (2007). Physicochemical characteristics of goat and sheep milk. Special Issue book on Goat milk and Sheep milk. Small Ruminant Res. J. 68, 88-113. crossref(new window)

Petrillo, Jr. E. W. and Ondetti, M. A. (1982) Angiotensin converting enzyme inhibitors: Medicinal chemistry and biological actions. Med. Res. Rev. 2, 1-41. crossref(new window)

Playne, M. J., Bennett, L. E., and Smithers, G. W. (2003) Functional dairy foods and ingredients. Australian J. Dairy Technol. 58, 242-264.

Qian, Z. Y., Jolles, P., Migliore-Samour, D., Schoentgen, F., and Fiat, A. M. (1995). Sheep kappa-casein peptides inhibit platelet aggregation. Biochim Biophys Acta 1244, 411-417. crossref(new window)

Regester, G. O., Smithers, G. W., Mitchell, I. R., McIntosh, G. H., and Dionysius, D. A. (1997) Bioactive factors in milk: Natural and induced. In: Milk composition, production and biotechnology. Welch, R., Burns, D., Davis, S. Popay, A., and Prosser, C. (ed) CAB International. pp. 119-132.

Rival, S. G., Boeriu, C. G., and Wichers, H. J. (2001) Caseins and casein hydrolysates. 2. Antioxidativeproperties and relevance to lipoxygenase inhibition. J. Agr. Food Chem. 4, 295-302.

Rokka, T., Syvoja, E. L, Tuominen, J., and Korhonen, H. (1997) Release of bioactive peptides by enzymatic proteolysis of Lactobacillus GG fermented UHT milk. Milchwissenschaft 52, 675-678.

Roy, M. K., Watanabe, Y., and Tamai, Y. (1999) Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J. Biosci. Bioeng. 88, 426-432. crossref(new window)

Schanbacher, F. L., Talhouk, R. S., Murray, F. A., Gherman, L. I., and Willet, L. B. (1998) Milk-born bioactive peptides. Int. Dairy J. 8, 393-403. crossref(new window)

Schlimme, E. and Meisel, H. (1995) Bioactive peptides derived from milk proteins. Structural, physiological, and analytical aspects. Die Nahrung 39, 1-20. crossref(new window)

Shah, N. P. (2000) Effects of milk-derived bioactives: an overview. Brit. J. Nutr. 84, S3-S10.

Stoeck, M., Ruegg, C., Miescher, S., Carrel, S., Cox, D., Von Fliedner, V., and Alkan, S. (1989) Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta 1 and beta 2. J. Immunol. 143, 3258-3265.

Suetsuna, R., Ukeda, H., and Ochi, H. (2000) Isolation and characterization of free radical scavenging activities peptides derived from casein. J. Nutr. Biochem. 11, 128-131. crossref(new window)

Tani F., Shiiota A., Chiba H., and Yoshikawa M. (1994) Saerorphin, and opioid peptide derived from bovine serum albumin. In: β-Casomorphins and Related Peptides: Recent Developments. V. Brandtl and H. Teschemacher, (ed) Weinheim: VCH, Germany.

Théolier, J., Fliss, I., Jean, J., and Hammami, R. (2013). Milk AMP: a comprehensive database of antimicrobial peptides of dairy origin. Dairy Sci. Technol. 94, 181-193.

Viljoen, M. (1995) Lactoferrin: a general review. Haematologica 80, 252-267.

Wakabayashi, H., Takase, M., and Tomita, M. (2003) Lactoferricin derived from milk proteinlactoferrin. Curr. Pharm. Des. 9, 1277-1287. crossref(new window)

Wilson, Md. and Rudel, L. L. (1994) Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J. Lipid Res. 35, 943-955.

Wu, F. Y. and Elsasser, T. H. (1995) Studies on cell growth promoting activity in goat milk. J. Chinese Agric. Chem. Soc. 33, 326-332.

Yoshikawa, M., Sasaki, R., and Chiba, H. (1981) Effect of chemical phosphorylation of bovine casein components on the properties related to casein micelle formation. Agr. Bio. Chem. 45, 909-914. crossref(new window)

Zhang, X. and Beynen, A. (1993) Lowering effect of dietary milk-whey protein v. casein on plasmaand liver cholesterol concentrations in rats. Brit. J. Nutr. 70, 139-146. crossref(new window)