Advanced SearchSearch Tips
Effects of Schizonepeta Spica water extrect on the OVA-induced BALB/c mice model of allergic rhinitis
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : The Korea Journal of Herbology
  • Volume 30, Issue 6,  2015, pp.39-46
  • Publisher : The Korea Association of Herbology
  • DOI : 10.6116/kjh.2015.30.6.39.
 Title & Authors
Effects of Schizonepeta Spica water extrect on the OVA-induced BALB/c mice model of allergic rhinitis
Song, Dea-Uk; Heo, Jun; Lee, SungYub; Kim, Jae-Hyun; Lee, Bina; Min, Ju-Hee; Kim, Eun-Young; Sohn, Youngjoo; Jung, Hyuk-Sang;
  PDF(new window)
Objectives : The aim of this study was to evaluate the effect of Schizonepeta Spica water extract (SS) on the OVA-induced BLAB/c mice allergic rhinitis model.Methods : Thirty two BALB/c mice were equally assigned to 4 groups; the sham group, the control group, the cetirizine hydrochloride (Cet) treatment group, and the SS treatment group. Sham group was sensitized and challenged with saline, and the other groups were sensitized and challenged with OVA. The dosage of SS was 7.6 mg /kg·day, and Cet was 10 mg/kg·day. Nasal rubbing and sneezing were measured by the behavior observation. The concentrations of IL-1β, IL-10, TNF-α and MIP-2 in the sera of allergic rhinitis model were measured by mouse cytokine/chemokine magnetic bead panel kits. Total IgE and OVA-specific IgE were measured by ELISA method. Epithelial thickness and eosinophil infiltration of nasal septum was investigated by histological examination.Results : The clinical symptoms that increased in control group were significantly reduced in SS-treated group. Serum total IgE and OVA-specific IgE in the SS-treated group were significantly reduced compared to the control group. The concentration of IL-1β, IL-10, TNF-α and MIP-2 in SS-treated group showed a significant reduction compared to the control group. The infiltration of eosinophil into nasal tissues of SS-treated group decreased markedly compared to control group, and thickness of nasal septum in nasal mucosa showed a significant reduction compared to control group.Conclusions : According to the above result, it is suggested that SS may inhibit the early and late phase of allergic rhinitis reaction.
allergic rhinitis;Schizonepeta Spica;cetrizine hydorchloride;OVA-specific IgE;
 Cited by
Oral administration of the Herbal Medicines in animal models for treatment of Allergic Rhinitis: a Review of Animal Study Reports Published in Korea, The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, 2016, 29, 1, 131  crossref(new windwow)
Rha YH. Allergic rhinitis in children : diagnosis and treatment. Korean J Pediatrics. 2006 ; 49(6) : 593. crossref(new window)

Lee MH. Lippincott’s Illustrated Reviews : Immunology. Seoul : shinilbooks. 2008 : 195-9.

Kim CW. Current Update on Allergic Rhinitis. Korean J Int Med. 2012 ; 83(3) : 298-9. crossref(new window)

Kwon HC. Korean Social Trends 2012. Seoul : Statistical research institute. 2012 : 114-21.

Kim SY. Economic Burden of Allergic Rhinitis in Korea. 2009 : 31-2.

Shin MK. Clinical traditional herbalogy. Seoul : Yeong Lim's publisher. 2000 : 338-9.

The textbook complication committee of Korean herbalogy. Korean Herbalogy. Seoul : Yeong Lim's publisher. 2004 : 159-60.

Hoe J. Jeong-kyo Donguibogam. Seoul : Hanmi medical publishing Co. 2001 : 319-21.

Park JH, Hong SU. The Effect of Hyunggaeyyungyo-tang of Suppression of iNOS Production on Mice with Allergic Rhisitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2012 ; 25(1) ; 12-21. crossref(new window)

Park KH. Effects of HyeongBangPaeDokSan (HBPDS) on allergic contact dermatitis (ACD) induced by DNFB in mice. Dongsin Univ. 2014

Kang YH et al. Effects of Putative Anticancer Herb Drugs on Rat Natural Killer(NK) Cell Activity. J Korean Med. 1987 ; 8(1) : 53-74.

Lim JH. Sensitivity testing of tumor cells to putative anticancer drugs. Kyung Hee Univ Oriental Med J. 1986 ; 9 : 241-66.

Cho SI. Regularoty mechanism of Schizonepeta tenuifolia Briquet on HMC-1 mast cells; microarray analysis. Kyung Hee Univ. 2009.

Choi YY, Kim MH, Kim JH, Jung HS, Sohn Y, Choi YJ, Hwang MK, Kim SH, Kim J, Yang WM. Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice. Phytotherapy Res. 2013 ; 27(8) : 1131-5. crossref(new window)

Bachert C. The role of histamine in allergic disease: re-appraisal of itsinflammatory potential. Allergy. 2002 ; 57(4) : 287-96. crossref(new window)

Quraishi SA, Davies MJ, Craig TJ. Inflammatory responses in allergic rhinitis: Traditional approaches and novel treatment strategies. J Am Osteopath Assoc. 2004 ; 104(5 Suppl 5) : S7-15.

Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR, Lo D. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol. 1999 ; 162(5) : 2477-87.

Mandhane SN, Shah JH, Thennati R. Allergic rhinitis: An update on disease, present treatments and future prospects. Int Immoupharmacol. 2011 ; 11(11) : 1646-62. crossref(new window)

Min YG. The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2010 ; 2(2) : 65-76. crossref(new window)

Bachert C. The role of histamine in allergic disease: re-appraisal of itsinflammatory potential. Allergy. 2002 ; 57(4) : 287-96. crossref(new window)

Bradding P, Mediwake R, Feather IH, Madden J, Church MK, Holgate ST, Howarth PH. TNF alpha is localized to nasal mucosa mast cells and is released in acute allergic rhinitis. Clin Exp Allergy. 1995 ; 25(5) : 406-15. crossref(new window)

Bachert C, Wagenmann M, Hauser U. Proinflammatory cytokines: measurement in nasal secretion and induction of adhesion receptor expression. Int Arch Allergy Immunol. 1995 ; 107(1-3) : 106-8. crossref(new window)

Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 1992 ; 89(20) : 9784-8. crossref(new window)

Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer zum Buschenfelde KH, Strober W, Kollias G. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol. 1997 ; 27(7) : 1743-50. crossref(new window)

Artis D, Humphreys NE, Bancroft AJ, Rothwell NJ, Potten CS, Grencis RK. Tumor necrosis factor alpha is a critical component of interleukin 13–mediated protective T helper cell type 2 responses during helminth infection. J Exp Med. 1999 ; 190(7) : 953-62. crossref(new window)

Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med. 1997 ; 186(10) : 1737-47. crossref(new window)

Iwasaki M, Saito K, Takemura M, Sekikawa K, Fujii H, Yamada Y, Wada H, Mizuta K, Seishima M, Ito Y. TNF-α contributes to the development of allergic rhinitis in mice. J Allergy Clin Immunol. 2003 ; 112(1) : 134-40. crossref(new window)

Arock M, Zuany-Amorim C, Singer M, Benhamou M. Pretolani M. Interleukin-10 inhibits cytokine generation from mast cells. Eur J Immunol. 1996 ; 26(1) : 166-70. crossref(new window)

Royer B, Varadaradjalou S, Saas P, Guillosson JJ, Kantelip JP, Arock M. Inhibition of IgE-induced activation of human mast cells by IL-10. Clin Exp Allergy. 2001 ; 31(5) : 694-704. crossref(new window)

Takanaski S, Nonaka R, Xing Z, O’ Byrne P, Dolovich J, Jordana M. Interleukin 10 inhibits lipopolysaccharideinduced survival and cytokine production by human peripheral blood eosinophils. J Exp Med. 1994 ; 180(2) : 711-5. crossref(new window)

Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. Ⅳ. Th2 clones secrete a factor that inhibits cytokine production by Th1 clolnes. J Exp Med. 1989 ; 170(6) : 2081-95. crossref(new window)

Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, Wilcock LK, Staple SQ, Aalberse RC, Till SJ, Durham SR. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol. 2004 ; 172(5) : 3252-9. crossref(new window)

Jeannin P, Lecoanet S, Delneste Y, Gauchat JF. Bonnefoy JY. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol. 1998 ; 160(7) : 3555-61.

Ohmori H, Kanda T, Takai T, Hikida M. Induction of antigen-specific IgE response in murine lymphocytes by IL-10. Immunol Lett. 1995 ; 47(1-2) : 127-32. crossref(new window)

Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, Wenzel S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol. 1996 ; 97(6) : 1288-96. crossref(new window)

Lim S, Crawley E, Woo P, Barnes PJ. Haplotype associated with low inerleukin-10 production in patients with severe asthma. Lancet. 1998 ; 352 : 113. crossref(new window)

Heaton T, Rowe J, Turner S, Aalberse RC, de Klerk N, Suriyaarachchi D, Serralha M, Holt BJ, Hollams E, Yerkovich S, Holt K, Sly PD, Goldblatt J, Le Souef P, Holt PG. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with defferent wheezing phenotypes in children. Lancet. 2005 ; 365(9454) : 142-9. crossref(new window)

Akdis CA, Blesken T, Akdis M, Wuthrich B. Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest. 1998 ; 102(1) : 98-106. crossref(new window)

Feldmeyer L, Werner S, French LE, Beer HD. Interleukin-1, inflammasomes and the skin. Eur J Cell Biol. 2010 ; 89(9) : 638-44. crossref(new window)

Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009 ; 27 : 519-50. crossref(new window)

Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, van Deventer S, Cerami A. Cloning and characterization of cDNAs for murine macrephage inflammatory protein 2 and its human homologues. J Exp Med. 1990 ; 172(3) : 911-9. crossref(new window)

Tumpey TM, Fenton R, Molesworth-Kenyon S, Oakes JE, Lausch RN. Role for macrophage inflammatory protein 2 (MIP-2), MIP-1α, and interleukin-1α in the delayed-type hypersensitivity response to viral antigen. J Virol. 2002 ; 76(16) : 8050-7. crossref(new window)

Lilly CM, Nakamura H, Kesselman H, Nagler-Anderson C, Asano K, Garcia-Zepeda EA, Rothenberg ME, Drazen JM, Luster AD. Expression of Eotaxin by Humam Lung Epithelial Cells. J Clin Invest. 1997 ; 99(7) : 1767-73. crossref(new window)

Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 1994 ; 179(3) : 881-7. crossref(new window)