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Effect of the Lycii Fructus on multiple low-dose streptozotocin-induced diabetic rats
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  • Journal title : The Korea Journal of Herbology
  • Volume 30, Issue 6,  2015, pp.47-53
  • Publisher : The Korea Association of Herbology
  • DOI : 10.6116/kjh.2015.30.6.47.
 Title & Authors
Effect of the Lycii Fructus on multiple low-dose streptozotocin-induced diabetic rats
Oh, Tae Woo; Park, Yong-Ki;
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Objectives : This study was performed to investigate the anti-diabetic effect of the fruit extract of Lycium chinense Mill(Lycii Fructus, LF) on multiple low-dose streptozotocin-induced diabetic rats.Methods : Male Sprague-Dawley rats were divided into three groups; normal, STZ-control, Lycii Fructus extractorally administrated 300 ㎎/㎏ group (STZ-LF). Diabetes was induced in rats by consecutive injection of streptozotocin (STZ) at doses of 30 ㎎/㎏ for 5 days. After 4 weeks, all rats were sacrificed, Fasting blood glucose, total cholesterol (CHO), triglyceride (TG) and HDL-Cholesterol were measured in sera of rats. Histopathological changes of pancreas, kidney, liver and lung tissues were observed by microscope after H&E, Periodic acid-Schiff (PAS) and Masson`s trichrome staining. The changes of body weight, blood glucose, and food and water intake were also measured.Results : There were no differences in body, food intake and water intake in LF-administrated groups compared with STZ control group. However, LF extract significantly decreased the levels of serum glucose, CHO, TG and HDL-Cholesterol in diabetic rats. In histopathological analysis of kidney, liver and lung, LF-administrated groups showed the inhibition of morphological damage.Conclusions : These results suggest that LF have a biological action on multi low-dose STZ-induced diabetes in rats via decreasing the serum glucose, TG and TG levels and may protect the morphological changes of kidney, liver and lung.
Diabetes;Streptozotocin;multiple administration;Lycii Fructus;histopathological analysis;
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