Advanced SearchSearch Tips
Effects of Gamiolnyeo-jeon on Lipid Metabolism and Blood Glucose Level in db/db Mice
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : The Korea Journal of Herbology
  • Volume 31, Issue 2,  2016, pp.39-45
  • Publisher : The Korea Association of Herbology
  • DOI : 10.6116/kjh.2016.31.2.39.
 Title & Authors
Effects of Gamiolnyeo-jeon on Lipid Metabolism and Blood Glucose Level in db/db Mice
Sim, Boo-Yong; Kim, Dong-Hee;
  PDF(new window)
Objectives : Abnormal regulation of glucose and impaired lipid metabolism that result from a defective or deficient insulin are the key etiological factor in type 2 diabetes mellitus. The our study investigated the effects of Gamioknyeo-jeon (GO) on blood glucose and lipid metabolism improved by it in db/db mice (a murine model of type 2 diabetes mellitus).Methods : The animals were divided into 3 groups: Normal groups were not-treated C57BL/6 mice; Control groups were treated orally with DW in db/db mice; GO groups were treated orally with GO (200 ㎎/㎏/day) in db/db mice. After mice were treated with GO for 5 weeks, we measured AST, ALT, creatinine, BUN, body weight, food intake, blood glucose, insulin and lipid levels (total cholesterol, HDL cholesterol, and LDL cholesterol and atherogenic index(AI) and cardiac risk factor(CRF).Results : Serum AST, ALT, creatinine, BUN levels were not changed by GO do not show any toxic effects. GO groups were decreased in body weight, food intake and blood glucose level among compared to Control groups. Also, GO groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol and LDL cholesterol decrease). Finally, GO groups were increased the insulin compared to Normal and control groups.Conclusions : We suggest that GO may have the control effects of diabetes mellitus by improving blood glucose control and lipid metabolism.
blood glucose;Gamioknyeo-jeon;insulin;lipid metabolism;type 2 diabetic mellitus;
 Cited by
Korean Diabetes Association. Handbook of Diabetes. Seoul : E-PUBRIC. 2006 : 2-4.

Ceska R, Vrablik M, Sucharda P. Dyslipidemia and obesity 2011. Similarities and differences. Vnitr Lek. 2011 ; 57(3) : 248-53.

Mandavia CH, Aroor AR, Demarco VG, Sowers JR. Molecular and metabolic mechanisms of cardiac dysfunction in diabetes. Life Sci. 2013 ; 92(11) : 601-8. crossref(new window)

Norman L. Manual of endocrinology and metalolism. Seoul : Hanmibooks. 2010 : 665-6.

Bray GA. Office management of obesity. Seoul : Hanmibooks. 2005 : 242-6.

Hong WS. Hwang-Je-Nae-Gyeong-So-Moon. Seoul : Publisher of Oriental medicine. 1981 : 18, 138, 145, 163, 179, 180, 238, 249, 257, 263, 269, 274, 297, 299, 301, 304.

Oh TW, Kang SY, Park YK. Histological analysis of five organs in streptozotocin -induced diabetic rats. Kor J Herbol. 2013 ; 28(6) : 39-45. crossref(new window)

Jang GB. Kyungakjeonsuh. Seoul : Bubinbooks. 2007 : 972.

Yoo DH. Effects of silbieum and lieumjeon on rats with acute renal failure induced by gentamicin sulfate. Kyunghee University. 1990.

Jo CH, An JJ, Jo HK, Yoo HY, Seol IC, Kim YS. The Effect of Gamioknyeo-jeon on Spontaneously Hypertensive Rats. Korean J Orient Int Med. 2010 ; 31(1) : 142-52.

Han HK, Yoon SJ, Kim GH. Effects of compositae plants on plasma glucose and lipid level in streptozotocin induced diabetic rats. J Korean Soc Food Sci. 2009 ; 38(6) : 674-82. crossref(new window)

Han YK, Park YK. Effect of atractylodis rhizoma alba water extract on streptozotocin-induced diabetes in rats. Kor J Herbol. 2011 ; 26(4) : 23-30.

Han HK, Je HS, Kim GH. Effects of cirsium japonicum powder on plasma glucose and lipid level in streptozotocin induced diabetic rats. Korean J Food Sci Technol. 2010 ; 42(3) : 343-9.

Shah B, Sha D, Xie D, Mohler ER 3rd, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the national health and nutrition examination survey. Diabetes Care. 2012 ; 35(5) : 1074-8. crossref(new window)

Lee YJ, Lee YJ, Yoon JJ, Lee SM, Kim HY, Shin SH, Kang DG, Lee HS. Anti-diabetic and Anti-Inflammatory Effects of Water Extract of Ligustrum japonicum Leaves in db/db Mouse. Kor J Herbol. 2012 ; 27(6) : 107-14. crossref(new window)

Reaven GM, Bernstein R, Davis B, Olefsky JM. Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med. 1976 ; 60(1) : 80-8. crossref(new window)

Yoon JA, Son YS. Effects of fruits and stems of opunita ficus-indica on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr. 2009 ; 38(2) : 146-53. crossref(new window)

Han YK, Park YK. The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin -induced diabetes in rats. Kor J Herbol. 2013 ; 28(6) : 71-7. crossref(new window)

Korean Diabetes Association. Diabetes. 3rd ed. Seoul : Korean Diabetes Association. 2005 : 443-50.

Goldberg IJ. Clinical review 124 :Diabetic dyslipidemia: causes and consequences. J Clin Endocrinol Metab. 2001 ; 86(3) : 965-71. crossref(new window)

American Diabetes Association. Standards of medical care in diabetes-2010. Diabetes Care. 2010 ; 33(1) : S11-61. crossref(new window)

Syvänne M, Taskinen MR. Lipids and lipoproteins as coronary risk factors in non-insulin-dependent diabetes mellitus. Lancet. 1997 ; 350(1) : SI20-3. crossref(new window)

Kim EL, Kim CS, Lee HY, Lee HR, Kim EY, Yoon MC, Shin SS. Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice. Kor J Herbol. 2012 ; 27(2) : 69-75. crossref(new window)

Rosenfeld L. Lipoprotein analysis. Arch pathol Lab. 1989 ; 113(10) : 1101-10.

Lee YM. Effects of Barley Leaf Powder on Lipid Metabolism in Rats and its Antidiabetic Activity. Chosun University. 2011.

Song KE, Kim DJ, Park JW, Cho HK, Lee KW, Huh KB. Clinical Characteristics of Korean Type 2 Diabetic Patients According to Insulin Secretion and Insulin Resistance. Diabetes Metabolism J. 2007 ; 31(2) : 123-9.