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Experimental Research of ZrO2/BCP/PCL Scaffold with Complex Pore Pattern for Bone Tissue Regeneration
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 Title & Authors
Experimental Research of ZrO2/BCP/PCL Scaffold with Complex Pore Pattern for Bone Tissue Regeneration
Sa, Min-Woo; Shim, Hae-Ri; Kim, Jong Young;
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Recently, synthetic biopolymers and bioceramics such as poly (-caprolactone)(PCL), hydroxyapatite, tricalcium phosphate, biphasic calcium phosphate(BCP), and zirconia have been used as substrates to generate various tissues or organs in tissue engineering. Thus, the purpose of this study was the characterization of /BCP/PCL(ZBP) scaffold for bone tissue regeneration. Based on the result of single-line test, blended 3D ZBP scaffolds with fully interconnected pores and new complex pore pattern of -type and staggered-type were successfully fabricated using a polymer deposition system. Furthermore, the effect of ZBP scaffold on mechanical property was analyzed. In addition, in vitro cell interaction of ZBP scaffold on MG63 cells was evaluated using a cell counting kit-8(CCK-8) assay.
Polymer Deposition System;Complex Pore Pattern;/BCP/PCL;Scaffold;
 Cited by
Wang, H. J. and van Blitterswijk, C. A., 2010, "The Role of Three-Dimensional Polymeric Scaffold Configuration on the Uniformity of Connective Tissue Formation by Adipose Stromal Cells," BioMaterials, Vol. 31, pp. 4322-4329. crossref(new window)

Thavornyutikarn, B., Chantarapanich, N., Sitthiseripratip, K., Thouas, G. and Chen, Q., 2014, "Bone Tissue Engineering Scaffolding: Computer- Aided Scaffolding Techniques," Prog. Biomater., Vol. 3, No. 26, pp. 1-42.

Lu, L., Zhang, Q., Wootton, D., Chiou, R., Li, D., Lu, B., Lelkes, P. and Zhou, J., 2012, "Biocompatibility and Biodegradation Studies of PCL/TCP Bone Tissue Scaffold Fabricated by Structural Porogen Method," J. Mater. Sci: Mater. Med., Vol. 23, pp. 2217-2226.

Shor, L., Guceri, S., Chang, R., Gordon, J., Kang, Q., Hartsock, L., An, Y. and Sun, W., 2009, "Precision Extruding Deposition (PED) Fabrication of Polycaprolactone (PCL) Scaffold for Bone Tissue Engineering," Biofabrication, 015003.

Ha, S. W. and Kim, J. Y., 2014, "Fabrication of Blended PCL/TCP Scaffolds by Mixture Ratio of TCP Using Polymer Deposition System," J. Korean Soc. Precis. Eng., Vol. 31, No. 9, pp. 791-797. crossref(new window)

Heo, S. J., Kim, S. E., Wei, J., Hyun, Y. T., Yun, H. S., Kim, D. H., Shin, J. W. and Shin, J. W., 2009, "Fabrication and Characterization of Novel Nano- and Micro-HA/PCL Composite Scaffolds Using a Modified Rapid Prototyping Process," J. Biomed Mater. Res. Part A, Vol. 89A, pp. 108-116.

Park, S. A., Lee, S. H. and Kim, W. D., 2011, "Fabrication of Porous Polycaprolactone/ Hydroxyapatite (PCL/HA) Blend Scaffolds Using a 3D Plotting System for Bone Tissue Engineering," Bioprocess. Eng., Vol. 34, No. 4, pp. 505-513.

Kwak, K. A., Jyoti, A. and Song, H. Y., 2014, "In Vitro and in Vivo Studies of Three Dimensional Porous Composites of Biphasic Calcium Phosphate/poly Caprolactone: Effect of Bio- Functionalization for Bone Tissue Engineering," Applied Surface Science, Vol. 301, pp. 307-314. crossref(new window)

Kim, D. H., Kim, K. L., Chun, H. H., Kim, T. W., Park, H. C. and Yoon S. Y., 2014, "In vitro Biodegradable and Mechanical Performance of Biphasic Calcium Phosphate Porous Scaffolds with Unidirectional Macro-Pore Structure," Ceram. Int., Vol. 40, pp. 8293-8300. crossref(new window)

Gao, C., Yang, B., Hu, H., Liu, J., Shuai, C. and Peng, S., 2013, "Enhanced Sintering Ability of Biphasic Calcium Phosphate by Polymers Used for Bone Scaffold Fabrication," Mater. Sci. Eng., C, Vo. 33, pp. 3802-3810. crossref(new window)

Descamps, M., Biolet, L., Moreau, G., Tricoteaux, A., Lu, J., Leriche, A., Lardot, V. and Cambier, F., 2013, "Processing and Properties of Biphasic Calcium Phosphates Bioceramics Obtained by Pressureless sintering and hot isostatic pressing," J. Eur. Ceram. Soc., Vol. 33, pp. 1263-1270. crossref(new window)

Jung, G. I., Kim, J. S., Choi, J. H. and Jun, J. H., 2010, "The Trend and Prospect of Biomaterials in the Biomedical Engineering Field," KIC News, Vol. 13, No. 6, pp. 18-31.

Sa, M. W. and Kim, J. Y., 2013, "Effect of various blending ratios on the cell characteristics of PCL and PLGA scaffolds fabricated by polymer deposition System," Int. J. Prec. Eng. Manuf., Vol. 14, No. 4, pp. 649-655. crossref(new window)

Sa, M. W. and Kim, J. Y., 2013, "Design of Multi- Scaffold Fabrication System for Various 3D Scaffolds," J. Mech. Sci. Tech., Vol. 27, No. 10, pp. 2961-2966. crossref(new window)

Lee, J. S., Cha, H. D., Shim, J. H., Jung, J. W., Kim, J. Y. and Cho, D. W., 2012, "Effect of Pore Architecture and Stacking Direction on Mechanical Properties of Solid Freeform Fabrication-Based Scaffold for Bone Tissue Engineering," J. Biomed. Mater. Res. Part A, Vol. 100A, pp. 1846-1853. crossref(new window)

Kim, K. B., Yeatts, A., Dean, D. and J. P. Fisher, 2010, "Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression," Tissue Eng. B, Vol. 16, pp. 523-539.

Kim, H. J., Park, I. K., Kim, J. H., Cho, C. S. and Kim, M. S., 2012, "Gas Foaming Fabrication of Porous Biphasic Calcium Phosphate for Bone Regeneration," Tissue Eng. Regen. Med., Vol. 9, No. 2, pp. 63-68. crossref(new window)

Guo, H., Su, J., Wei, J., Kong, H., Liu, C., 2009, "Biocompatibility and Osteogenicity of Degradable Ca-Deficient Hydroxyapatite Scaffolds from Calcium Phosphate Cement for Bone Tissue Engineering," Acta Biomater., Vol. 5, No. 1, pp. 268-278. crossref(new window)

Tripathi, G. and Basu, B., 2012, "A porous Hydroxyapatite Scaffold for Bone Tissue Engineering: Physico-Mechanical and Biological Evaluations," Ceramics Inter., Vol. 38, No. 1, pp. 341-349. crossref(new window)

Shim, J. H., Moon, T. S., Yun, M. J., Jeon, Y. C., Jeong C. M., Cho, D. W. and Huh, J. B., 2012, "Stimulation of Healing Within a Rabbit Calvarial Defect by a PCL/PLGA Scaffold Blended with TCP Using Solid Freeform Fabrication Technology," J. Mater. Sci. Mater. Med., Vol. 23, No. 12, p. 2993-3002. crossref(new window)

Shuai, C., Gao, C. and Nie, Y., Hu, H., Zhou, Y. and Peng, S., 2011, "Structure and Properties of Nano- Hydroxyapatite Scaffolds for Bone Tissue Engineering with a Selective Laser Sintering System," Nanotechnol., Vol. 22, No. 28, 285703.

Seol, Y. J., Park, D. Y., Park, J. Y., Kim, S. W., Park, S. J. and Cho, D. W., 2013, "A New Method of Fabricating Robust Freeform 3D Ceramic Scaffolds for Bone Tissue Regeneration," Biotechnol. Bioeng., Vol. 110, No. 5, pp. 1444-1455. crossref(new window)

Tripathi, G. and Basu, B, 2012, "A Porous Hydroxyapatite Scaffold for Bone Tissue Engineering Physic-Mechanical and Biological Evaluations," Ceram. Inter., Vol. 38, pp. 341-349. crossref(new window)

Vorndran, E., Klarner, M., Klammert, U., Grover, L. M., Patel, S., Barralet, J. E. and Gbureck, U., 2008, "3D Powder Printing of $\beta$-Tricalcium Phosphate Ceramics Using Different Strategies," Adv. Eng. Mater., Vol. 10, pp. 67-71. crossref(new window)