Advanced SearchSearch Tips
A Study on Fabrication of 3D Dual Pore Scaffold by Fused Deposition Modeling and Salt-Leaching Method
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
A Study on Fabrication of 3D Dual Pore Scaffold by Fused Deposition Modeling and Salt-Leaching Method
Shim, Hae-Ri; Kim, Jong Young;
  PDF(new window)
Scaffold fabrication technology using a 3D printer was developed for damaged bone tissue regeneration. A scaffold for bone tissue regeneration application should be biocompatible, biodegradable, and have an adequate mechanical strength. Moreover, the scaffold should have pores of satisfactory quantity and interconnection. In this study, we used the polymer deposition system (PDS) based on fused deposition modeling (FDM) to fabricate a 3D scaffold. The materials used were polycaprolactone (PCL) and alginic acid sodium salt (sodium alginate, SA). The salt-leaching method was used to fabricate dual pores on the 3D scaffold. The 3D scaffold with dual pores was observed using SEM-EDS (scanning electron microscope-energy dispersive spectroscopy) and evaluated through in-vitro tests using MG63 cells.
Fused Deposition Modeling;Salt-Leaching;Polymer Deposition System;Dual Pore Scaffold;
 Cited by
Bonassar, L. J. and Vacanti, C. A., 1998, "Tissue Engineering: The First Decade and Beyond," Journal of Cellular Biochemistry, Vol. 72, No. 30-31, pp. 297-303. crossref(new window)

Cancedda, R., Dozin, B., Giannoni, P. and Quarto, R., 2003, "Tissue Engineering and Cell Therapy of Cartilage and Bone," Matrix Biology, Vol. 22, No. 1, pp. 81-91. crossref(new window)

Vats, A., Tolley, N. S., Polak, J. M. and Gough, J. E., 2003, "Scaffolds and Biomaterials for Tissue Engineering: are View of Clinical Applications," Clinical Otolaryngology and Alliend Sciences, Vol. 28, No. 3, pp.165-172. crossref(new window)

Moutos, F. T., Freed, L. E. and Guilak, F., 2007, "A Biomimetic Three-dimensional Woven Composite Scaffold for Functional Tissue Engineering of Cartilage," Nature Materials, Vol. 6, pp. 162-167. crossref(new window)

Uchida, T., Ikeda, S., Oura, H., Tada, M., Nakano, T., Fukuda, T., Matsuda, T., Negoro, M. and Arai, F., 2008, "Development of Biodegradable Scaffolds based on Patient-specific Arterial Configuration," Journal of Biotechnology, Vol. 133, No. 2, pp. 213-218. crossref(new window)

Lee, S. B., Kim, Y. H., Chong, M. S., Hong, S. H. and Lee, Y. M., 2005, "Study of Gelatin-containing Artificial Skin V: Fabrication of Gelatin Scaffolds using a SA-leaching Method," Biomaterials, Vol. 26, No. 14, pp. 1961-1968. crossref(new window)

Cho, Y. S., Kim, B. S., You, H. K. and Cho, Y. S., 2014, "A Novel Technique for Scaffold Fabrication: SLUP (salt leaching using powder)," Current Applied Physics, Vol. 14, No. 3, pp. 371-377. crossref(new window)

Kim, H. J., Park, I. K., Kim, J. H., Cho, C. S. and Kim, M. S., 2012, "Gas Foaming Fabrication of Porous Biphasic Calcium Phosphate for Bone Regeneration," Tissue Engineering and Regenerative Medicine, Vol. 9, No. 2, pp. 63-68. crossref(new window)

Ramay, H. R. and Zhang, M., 2003, "Preparation of Porous Hydroxyapatite Scaffolds by Combination of the Gel-casting and Polymer Sponge Methods," Biomaterials, Vol. 24, No. 19, pp. 3293-3302. crossref(new window)

Lee, J. W., Kim, J. Y. and Cho, D. W., 2010, "Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering," International Journal of Stem Cells, Vol. 3, No. 2, pp. 85-95. crossref(new window)

Ha, S. W. and Kim, J. Y., 2014, "Fabrication and Evaluation of Hybrid Scaffold by Nano-Micro Precision Deposition System," Trans. Korean Soc. Mech. Eng. A, Vol. 38, No.8, pp. 875-880. crossref(new window)

Ahn, S.H., Koh, Y. H. and Kim, G. H., 2010, "A three-dimensional Hierarchical Collagen Scaffolds Fabricated by a Combined Solid Freeform Fabrication (SFF) and Electrospinning Process to Enhance Mesenchymal Stem Cell (MSC) Proliferation," Journal of Micromechanice Microengineering, Vol. 20, No. 6, pp. 1-7.

Olakanmi, E. O., 2013, "Selective Laser Sintering /Melting (SLS/SLM) of Pure Al, Al-Mg, and Al-Si Powders: Effect of Processing Conditions and Powder Properties," Journal of Materials Processing Technology, Vol. 213, No. 8, pp. 1387-1405. crossref(new window)

Sa, M. W. and Kim, J. Y., 2013, "Effect of Various Blending Ratios on the Cell Characteristics of PCL and PLGA Scaffolds Fabricated by Polymer Deposition System," International Journal of Precision Engineering and Manufacturing, Vol. 14, No. 4, pp. 649-655. crossref(new window)

Cho, Y. S., Hong, M. W., Kim, S. Y., Lee, S. J., Lee, J. H., Kim, Y. Y. and Cho, Y. S., 2014, "Fabrication of Dual-pore Scaffolds using SLUP (Salt leaching using powder) and WNM (wire-network molding) Techniques," Materials Science and Engineering C, Vol. 45, pp. 546-555. crossref(new window)

Baek, S. K., 2012, "Bone Regeneration with Polycaprolactone Scaffold Synthesized with the Combination of RP Method and Salt leaching," D.D.S., Graduate School of Clinical Dentistry, Korea University.

Martina, M. and Hutmacher, D. W., 2007, "Biodegradable Polymers Applied in Tissue Engineering Research: a Review," Polymer International, Vol. 56, No. 2, pp. 145-157. crossref(new window)

Wang, L., Shelton, R. M., Cooper, P. R., Lawson, M., Triffitt, J. T. and Barralet, J. E., 2003, "Evaluation of Sodium Alginate for Bone Marrow Cell Tissue Engineering," Biomaterials, Vol. 24, No. 20, pp. 3475-3481. crossref(new window)

Park, K. E., Park, S. A., Kim, G. H. and Kim, W. D., 2008, "Preparation and Characterization of Sodium Alginate/PEO and Sodium Alginate/PVA Nanofiber," Polymer(Korea), Vol. 32, No. 3, pp. 206-212.

Lee, D.G., Lee, G. H., Jang, K. H., Chae, H. J. and Moon, J. D., 2012, "A Suspicious Case of Chloroform Induced Acute Toxic Hepatitis in Laboratory Worker," Korean Journal of Occupational Environmental Medicine, Vol. 24, No. 3, pp. 304-310.