JOURNAL BROWSE
Search
Advanced SearchSearch Tips
A Microfluidic Chip-Based Creatinine Filtration Device
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
A Microfluidic Chip-Based Creatinine Filtration Device
Lee, Sack; Shin, Dong-Gyu; Nguyen, Thanh Qua; Park, Woo-Tae;
  PDF(new window)
 Abstract
The number of people suffering from renal disease increases every year. One of the most common treatments (clinical care options) for renal diseases is hemodialysis. However it takes a long time and has a high cost. Therefore, the importance of artificial kidney research has risen. Filtering creatinine from blood is one of the prime renal functions. Thus, we designed a novel two channel microfluidic chip focused on that function. In order to bond the individual polydimethylsiloxane layers, we have developed a housing system using acrylic plastic frame. This method has significant advantages in changing filter membranes. We use anodic aluminum oxide for the filter membrane. We analyzed the difference in the absorbance values for various creatinine concentrations using the Jaffe reaction. For the purpose of acquiring a standard equation to quantify the creatinine concentration, we interpolated the measured data and confirmed the concentration of the filtered solution. Through this experiment, we determined how the filtration efficiency depended on the flow rate and creatinine concentration.
 Keywords
Microfluidic;AAO;Filtration;Housing;
 Language
Korean
 Cited by
 References
1.
Xue, J. L., Ma, J. Z., Louis, T. A. and Collins, A. J., 2001, "Forecast of the Number of Patients with End- Stage Renal Disease in the United States to the Year 2010," Journal of the American Society of Nephrology, 12(12), pp. 2753-2758.

2.
Huh, D., Matthews, B. D., Mammoto, A., Montoya- Zavala, M., Hsin, H. Y. and Ingber, D. E., 2010, "Reconstituting Organ-Level Lung Functions on a Chip," Science, 328(5986), pp. 1662-1668. crossref(new window)

3.
Barr, D. B., Wilder, L. C., Caudill, S. P., Gonzalez, A. J., Needham, L. L. and Pirkle, J. L., 2005, "Urinary Creatinine Concentrations in the US Population: Implications for Urinary Biologic Monitoring Measurements," Environmental Health Perspectives, 192-200.

4.
Hill, R. H. Jr, Ashley, D. L., Head, S. L., Head, S. L. and Pirkle, J. L., 1995, "p-Dichlorobenzene Exposure Among 1 000 Adults in the United States," Archives of Environmental Health: An International Journal, 50(4), pp. 277-280.

5.
Shealy, D. B., Barr, J. R., Ashley, D. L., Patterson Jr, D. G., Camann, D. E. and Bond, A. E., 1997, "Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family," Environmental Health Perspectives, 105(5), 510. crossref(new window)

6.
Zhang, J., Tan, K. L. and Gong, H. Q., 2001, "Characterization of the Polymerization of SU-8 Photoresist and Its Applications in Micro-Electro- Mechanical Systems (MEMS)," Polymer Testing, 20(6), pp. 693-701. crossref(new window)

7.
Shelby, J. P., White, J., Ganesan, K., Rathod, P. K. and Chiu, D. T., 2003, "A Microfluidic Model for Single-Cell Capillary Obstruction by Plasmodium Falciparum-Infected Erythrocytes," Proceedings of the National Academy of Sciences, 100(25), pp. 14618-14622.

8.
Li, X., Chen, W., Liu, G., Lu, W. and Fu, J., 2014, "Continuous-Flow Microfluidic Blood Cell Sorting for Unprocessed Whole Blood Using Surface-Micromachined Microfiltration Membranes," Lab on a Chip, 14(14), pp. 2565-2575. crossref(new window)

9.
Kang, T. G., Yoon, Y. J., Ji, H., Lim, P. Y. and Chen, Y., 2014, "A Continuous Flow Micro Filtration Device for Plasma/Blood Separation Using Submicron Vertical Pillar Gap Structures," Journal of Micromechanics and Microengineering, 24(8), 087001. crossref(new window)

10.
Kaazempur-Mofrad, M. R., Vacanti, J. P., Krebs, N. J. and Borenstein, J. T., 2004, "A MEMS-Based Renal Replacement System," In Proceedings of the Solid State Sensor, Actuator, and Microsystems Workshop, pp. 6-10.