Advanced SearchSearch Tips
Convergence Studies of NO Homeostasis in Cellular Signalling
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Journal of Digital Convergence
  • Volume 13, Issue 12,  2015, pp.461-467
  • Publisher : The Society of Digital Policy and Management
  • DOI : 10.14400/JDC.2015.13.12.461
 Title & Authors
Convergence Studies of NO Homeostasis in Cellular Signalling
Oh, Hee-Kyun; Do, Eun-Young; Park, Hae-Ryoung;
  PDF(new window)
Saussurea lappa is known for a variety of physiological activities as a component but has not known to show the effect of the cellular signaling pathway. We investigated the anti-inflammatory effects by Saussurea lappa ethanol extract on the LPS(lipopolysaccharide) induced nitric oxide (NO) production by RAW 264.7 cell line. It shows the expressions of iNOS and COX-2 at the transcriptional level (RT-PCR). The Saussurea lappa ethanol extract showed transcriptional expression levels of pro-inflammatory cytokine TNF- and IL- induced by LPS(lipolysaccharide) in RAW264.7 cell line. Saussurea lappa ethanol extract reduced the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the RNA levels in a concentration-dependent manner. The finding that ethanol extract of Saussurea lappa has an influence on NO (nitric oxide) homeostasis in the study of the action mechanism on the macrophage-mediated inflammatory reaction was considered in terms of convergence. And it is to provide an important basis for the prevention and treatment of inflammatory diseases in the future.
Cellular Signalling;COX-2(cyclooxygenase-2);Convergence;Homeostasis;NO(nitric oxide);Saussurea lappa;
 Cited by
후각신경세포의 손상 및 재생 연구모델의 융합연구,정윤미;박종수;김철희;유관희;

한국융합학회논문지, 2016. vol.7. 2, pp.61-67 crossref(new window)
P. Batchelor, The changing epidemiology of oral diseases in the elderly, their growing importance for care and how they can be managed. Age Ageing, Vol. 44, No. 6, pp. 1064-1070, 2015. crossref(new window)

D. J. Zuluaga, J. Ferreira, J. A. Montoya, T. Willumsen, Oral health in institutionalised elderly people in Oslo, Norway and its relationship with dependence and cognitive impairment. Gerodontology, Vol. 29, No. 2, pp. 420-426, 2012. crossref(new window)

K. Sanjeev, S. Naganandini, R. Vasuda, N. Sachin, R. Rekha, M. S. Madhuniranjanswamy, Oral Hygiene Status of Institutionalised Dependent Elderly in India - a Cross-Sectional Survey. Can Geriatr J., Vol. 18, No. 2, pp. 51-56, 2015.

F. Cindy, Iron Deficiency Anemia: A Guide to Oral Iron Supplements. Clinical Correlation, 2015.

M. Harold, C. L. Marc, Oral Microbial Ecology and the Role of Salivary Immunoglobulin A. Microbiol. Mol. Biol. Rev. Vol. 62 No. 1 pp. 71-109, 1998.

W. C. Nance, S. E. Dowd, D. Samarian, J. Chludzinski, J. Delli, J. Battista, A. H. Rickard, A high-throughput microfluidic dental plaque biofilm system to visualize and quantify the effect of antimicrobials. Antimicrob Chemother, Vol. 68, No. 11, pp. 2550-2560, J 2013. crossref(new window)

D. M. Philip, Dental plaque as a biofilm and a microbial community-implications for health and disease. BMC Oral Health, Vol. 6(Suppl 1):S14, 2006. crossref(new window)

J. Y. Choi, E. H. Choi, H. W. Jung, J. S. Oh, W. H. Lee, J. G. Lee, J. K. Son, Y. Kim, S. H. Lee, Melanogenesis inhibitory compounds from Saussureae Radix. Arch Pharm Res. Vol. 31, No. 3, pp. 294-299, 2008. crossref(new window)

N. H. Jung, J. Y. Ha, K. R. Min, F. Shibata, H. Nakagawa, S. S. Kang, I. M. Chang, Y. S. Kim, Reynosis from Saussurea lappa as inhibitor on CINC-1 induction in LPS-stimulated NRK-52E cells. Planta Med, Vol. 64, pp. 454-456, 1998. crossref(new window)

Y. J. Jeon, H. S. Lee, S. Y. Yeon, J. H. Ko, K. M. An, S. W. Yu, J. H. Kang, B. Y. Hwang, T. Y. Kin. Inhibitory effect of dehydrocostuslactone isolated from Sussureae Radix on CDK2 activity. Kor J Pharmacogn 36: 97-101.2005.

J. L. Ebersole, M. A. Taubmam, The protective nature of hostresponses in periodontal diseases. Periodontol 2000, Vol. 5, pp. 112-141, 1994. crossref(new window)

K. S. Kornman, R. C. Page, M. S. Tonetti, The host response tothe microbial challenge in periodontitis: assembling the play-ers. Periodontol 2000, Vol. 14, pp. 33-53, 1997. crossref(new window)

H. R. Park, S. J. Hong, Research on Natural Medicine for Wellness and Oral Health, The Journal of Digital Policy & Management, Vol. 13, No. 5, pp. 357-1363, 2015.

T. Kirikae, T. Nitta, F. Kirikae, T. Suda, S. Kusumoto, N. Qureshi, M. Nakano, Lipopolysaccharides (LPS) of oral black pigmented bacteria induce tumor necrosis factor production by LPS-refractory C3H/HeJ macrophages in a way different fromthat of Salmonella LPS. Infect Immun, Vol. 67, pp. 17-36, 1999.

K. Seibert, Y. Zhang, K. Leahy, S. Hauser, J. Masferrer, W. Perkins, L. Lee, P. Ksakson, Pharmacological andbiochemical demonstration of the role of cyclooxygenase 2 ininflammation and pain. Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, pp. 12013-12017, 1994. crossref(new window)

M. Feldmann, F. M. Brennan, R. N. Maini, Role of cytokines in rheumatoid arthritis. Annual Review of Immunology, Vol. 14, pp. 397-440, 1996. crossref(new window)

Y. C. Hseu, F. Y. Wu, J. J. Wu, J. Y. Chen, W. H. Chang, F. J. Lu, Y. C. Lai, H. L. Yang, Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. Int Immunopharmacol, Vol. 5, pp. 1914-1925, 2005. crossref(new window)

B. Rudi, M. Alexander, Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells, and children. FEBS Letters, Vol. 275, No. 1-2, pp. 87-90, 1990. crossref(new window)

M. Takeshi, N. Toshio, H. Keiichi, S. Hiromichi, K. Ryuichi, S. Takao, Cyclosporin A Inhibits Nitric Oxide Synthase Induction in Vascular Smooth Muscle Cells. Hypertension, Vol. 25, pp. 764-768, 1995. crossref(new window)

M. Cetkovic-Cvrlje, D. L. Eizirik, TNF and IFN ${\gamma}$ potentiate the deleterious effects of IL-$1{\beta}$ on mouse pancreatic islets mainly viageneration of nitric oxide. Cytokine, Vol. 6, pp. 399-406, 1994. crossref(new window)