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Gene Polymorphism of TNF-α in Korean Generalized Aggressive Periodontitis
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  • Journal title : Journal of Digital Convergence
  • Volume 14, Issue 1,  2016, pp.321-326
  • Publisher : The Society of Digital Policy and Management
  • DOI : 10.14400/JDC.2016.14.1.321
 Title & Authors
Gene Polymorphism of TNF-α in Korean Generalized Aggressive Periodontitis
Kim, Il-Shin;
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 Abstract
The aim of this study was to evaluate the association between TNF polymorphism and generalized aggressive periodontitis (GAP) in Korean subjects. The study population consisted of 60 subjects with GAP and 81 reference group. Genomic DNA was extracted from the buccal swabs and the polymorphisms of , -238 promoter genes, and TNFR 2+587 were determined by PCR-RFLP using restriction enzymes. The genotype distribution in the GAP were 3.2%, 38.7%, and 82.35% for A/A, A/G and G/G genotypes of . At the position of , the genotype distribution in the GAP were 25.5% and 74.5% for A/G and G/G genotypes. Allele A frequency of were 67.6% in GAP and 72.2% in reference group. According to these findings, the polymorphism at and -238 may be associated with GAP in Korean.
 Keywords
Cytokines;Periodontitis;Polymorphism;;Single nucleotide;
 Language
Korean
 Cited by
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