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Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract
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  • Journal title : Toxicological Research
  • Volume 31, Issue 4,  2015, pp.363-369
  • Publisher : The Korean Society of Toxicology
  • DOI : 10.5487/TR.2015.31.4.363
 Title & Authors
Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract
Ha, Bi Gyeon; Park, Min Ah; Lee, Chae Myoung; Kim, Young Chul;
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 Abstract
We evaluated the antioxidant activity and anti-wrinkle effects of Aceriphyllum rossii leaf ethanol extract (ARLEE) in vitro using human dermal fibroblasts. The total polyphenol and flavonoid contents of ARLEE were 578.6 and 206.3 mg/g, respectively. At a concentration of , the electron-donating ability of ARLEE was 87.1%. In comparison with the vehicle, ARLEE treatment at significantly increased type I procollagen synthesis (p < 0.01) by 50.7%. In vitro ARLEE treatment (10 mg/mL) inhibited collagenase and elastase activity by 97.1% and 99.2%, respectively. Compared with the control, ascorbic acid treatment at significantly decreased matrix metalloproteinase (MMP)-1 protein expression (p < 0.01) by 37.0%. ARLEE treatment at significantly decreased MMP-1 protein expression (p < 0.01) by 46.1%. Ascorbic acid and ARLEE treatments at significantly decreased MMP-1 mRNA expression (p < 0.01) by 26.1% and 36.1%, respectively. From these results, we conclude that ARLEE has excellent antioxidant activity and even better anti-wrinkle effects than ascorbic acid in human dermal fibroblasts. These results suggest that ARLEE could be used in functional cosmetics for the prevention or alleviation of skin wrinkles induced by ultraviolet rays.
 Keywords
Aceriphyllum rossii;Antioxidant activity;Collagenase activity;MMP-1;Type I procollagen;
 Language
English
 Cited by
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