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A Study on Subchronic Inhalation Toxicity of 1-Chloropropane
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  • Journal title : Toxicological Research
  • Volume 31, Issue 4,  2015, pp.393-402
  • Publisher : The Korean Society of Toxicology
  • DOI : 10.5487/TR.2015.31.4.393
 Title & Authors
A Study on Subchronic Inhalation Toxicity of 1-Chloropropane
Chung, Yong Hyun; Han, Jeong Hee; Lee, Yong-Hoon;
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 Abstract
This study was conducted to measure toxicity of 1-chloropropane (CAS No. : 540-54-5). According to the OECD Test Guideline 413 (Subchronic inhalation toxicity: 90-day study), SD rats were exposed to 0, 310, 1,250, and 5,000 ppm of 1-chloropropane for 6 h/day, 5 day/week for 13 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, motor activity, ophthalmoscopy, hematology, serum chemistry, urinalysis, organ weights, gross and histopathological findings were compared between control and all tested groups. No mortality or remarkable clinical signs were examined during the study. No gross lesions or adverse effects on body weight, food consumption, motor activity, ophthalmoscopy, urinalysis, hematology, organ weights were observed in any of male or female rats in all tested groups. In serum biochemistry, glucose was significantly decreased in males of 1,250 and 5,000 ppm groups compared to control group in dose-dependent relationship. In histopathological examination, vacuolation of acinar cells was observed in pancreas of all male and female groups exposed to 1-chloropropane. In conclusion, no observable adverse effect level (NOAEL) was considered to be below 310 ppm/6 h/day, 5 day/week for rats.
 Keywords
1-Chloropropane;NOAEL;Subchronic inhalation toxicity;
 Language
English
 Cited by
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