Advanced SearchSearch Tips
Advancing Risk Assessment through the Application of Systems Toxicology
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Toxicological Research
  • Volume 32, Issue 1,  2016, pp.5-8
  • Publisher : The Korean Society of Toxicology
  • DOI : 10.5487/TR.2016.32.1.005
 Title & Authors
Advancing Risk Assessment through the Application of Systems Toxicology
Sauer, John Michael; Kleensang, Andre; Peitsch, Manuel C.; Hayes, A. Wallace;
  PDF(new window)
Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.
Systems toxicology;Risk assessment;
 Cited by
Towards a personalized risk assessment for exposure of humans to toxic substances, Cadernos Saúde Coletiva, 2016, 24, 2, 262  crossref(new windwow)
Shedding New Lights with the Breakthrough Ideas to Understand Current Trends in Modern Toxicology, Toxicological Research, 2016, 32, 1, 1  crossref(new windwow)
Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product, Chemical Research in Toxicology, 2017, 30, 4, 934  crossref(new windwow)
Sauer, J.M., Hartung, T., Leist, M., Knudsen, T.B., Hoeng, J. and Hayes, A.W. (2015) Systems toxicology: the future of risk assessment. Int. J. Toxicol., 34, 346-348. crossref(new window)

Hartung, T., van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N. and Thomas, R. (2012) Systems toxicology. Altex, 29, 119-128. crossref(new window)

Sturla, S.J., Boobis, A.R., FitzGerald, R.E., Hoeng, J., Kavlock, R.J., Schirmer, K., Whelan, M., Wilks, M.F. and Peitsch, M.C. (2014) Systems toxicology: from basic research to risk assessment. Chem. Res. Toxicol., 27, 314-329. crossref(new window)

Miller, R.M., Callahan, L.M., Casaceli, C., Chen, L., Kiser, G.L., Chui, B., Kaysser-Kranich, T.M., Sendera, T.J., Palaniappan, C. and Federoff, H.J. (2004) Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J. Neurosci., 24, 7445-7454. crossref(new window)