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Cadmium Exposure and Potential Health Risk from Foods in Contaminated Area, Thailand
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  • Journal title : Toxicological Research
  • Volume 32, Issue 1,  2016, pp.65-72
  • Publisher : The Korean Society of Toxicology
  • DOI : 10.5487/TR.2016.32.1.065
 Title & Authors
Cadmium Exposure and Potential Health Risk from Foods in Contaminated Area, Thailand
Chunhabundit, Rodjana;
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Man-made cadmium (Cd) emissions can be transported between environmental matrices and the food chain. Food is the primary source of Cd exposure among general population as a consequence of the bioconcentration of Cd from soil. Chronic Cd exposure has been reported to be associated with chronic kidney disease, osteoporosis, diabetes, cardiovascular disease and cancer. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) established the safe level of Cd intake as provisional tolerable monthly intake (PTMI) of in 2010. The major food groups that contribute to the most Cd exposure are rice and grains, shellfish and sea food, meat including edible offal, and vegetables. A number of studies reported the high Cd contaminated levels in foods from polluted areas in Thailand. The results are of high concern since the contaminations occur in foods that are major Cd contributors. Thus, in this review, the current situations of Cd contaminated foods in polluted areas of Thailand are summarized. In addition, the Cd intakes from selected scenarios are estimated to assess the potential health risk to consumers and the suggestions are also included.
Cadmium;Foods;Contaminated area;Health risk;Thailand;
 Cited by
Shedding New Lights with the Breakthrough Ideas to Understand Current Trends in Modern Toxicology, Toxicological Research, 2016, 32, 1, 1  crossref(new windwow)
Faroon, O., Ashizawa, A., Wright, S., Tucker, P., Jenkins, K., Ingerman, L. and Rudisill, C. (2012) Toxicological profile of cadmium, agency for toxic substances and disease registry. Atlanta, 273-274.

United Nations Environment Programme. (2010) Final review of scientific information on cadmium. Chemicals Branch DTIE, UN, pp. 87-89.

U.S. Geological Survey. (2015) Mineral commodity summaries 2015, U.S. Geological Survey, Reston, pp. 36-37.

Sarwar, N., Saifullah, Malhi, S.S., Zia, M.H., Naeem, A., Bibia, S. and Farida, G. (2010) Role of mineral nutrition in minimizing cadmium accumulation by plants. J. Sci. Food Agric., 90, 925-937.

Satarug, S., Garrett, S.H., Sens, M.A. and Sens, D.A. (2010) Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect., 118, 182-190.

Sabath, E. and Robles-Osorio, M.L. (2012) Renal health and the environment: heavy metal nephrotoxicity. Nefrologia, 32, 279-286.

Haswell-Elkins, M., Imray, P., Satarug, S., Moore, M.R. and O'dea, K. (2007) Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods. J. Exposure Anal. Environ. Epidemiol., 17, 372-377. crossref(new window)

Edwards, J.R., Diamantakos, E.A., Peuler, J.D., Lamar, P.C. and Prozialeck, W.C. (2007) A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer. BMC Physiol., 7, 1-14. crossref(new window)

Edwards, J.R. and Prozialeck, W.C. (2009) Cadmium, diabetes and chronic kidney disease. Toxicol. Appl. Pharmacol., 238, 289-293. crossref(new window)

Schutte, R., Nawrot, T.S., Richart, T., Thijs, L., Vanderschueren, D., Kuznetsova, T., van Hecke, E., Roels, H.A. and Staessen, J.A. (2008) Bone resorption and environmental exposure to cadmium in women: a population study. Environ. Health Perspect., 116, 777-783. crossref(new window)

Callana, A.C., Devineb, A., Qi, L., Ng, J.C. and Hinwood, A.L. (2015) Investigation of the relationship between low environmental exposure to metals and bone mineral density, bone resorption and renal function. Int. J. Hyg. Environ. Health, 218, 444-451. crossref(new window)

Akesson, A., Barregard, L., Bergdahl, I.A., Nordberg, G.F., Nordberg, M. and Skerfving, S. (2014) Non-renal effects and the risk assessment of environmental cadmium exposure. Environ. Health Perspect., 122,431-438.

Messner, B., Knoflach, M., Seubert, A., Ritsch, A., Pfaller, K., Henderson, B., Shen, Y.H., Zeller, I., Willeit, J., Laufer, G., Wick, G., Kiechl, S. and Bernhard, D. (2009) Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arterioscler. Thromb. Vasc. Biol., 29, 1392-1398. crossref(new window)

Jomova, K. and Valko, M. (2011) Advances in metal-induced oxidative stress and human disease. Toxicology, 283, 65-87. crossref(new window)

Kim, N.H., Hyun, Y.Y., Lee, K.B., Chang, Y., Rhu, S., Oh, K.H. and Ahn, C. (2015) Environmental heavy metal exposure and chronic kidney disease in the general population. J. Korean Med. Sci., 30, 272-277. crossref(new window)

Tellez-Plaza, M., Jones, M.R., Dominguez-Lucas, A., Guallar, E. and Navas-Acien, A. (2013) Cadmium exposure and clinical cardiovascular disease: a systematic review. Curr. Atheroscler. Rep., 15, 356. crossref(new window)

International Agency for Research on Cancer. (2012) IARC Monographs, Lyon, 100C, 141.

Joseph, P. (2009) Mechanisms of cadmium carcinogenesis. Toxicol. Appl. Pharmacol., 238, 272-279. crossref(new window)

Filipic, M. (2012) Mechanisms of cadmium induced genomic instability. Mutat. Res., 733, 69-77. crossref(new window)

Ryu, H.W., Lee, D.H., Won, H.R., Kim, K.H., Seong, Y.J. and Kwon, S.H. (2015) Influence of toxicologically relevant metals on human epigenetic regulation. Toxicol. Res., 31, 1-9. crossref(new window)

World Health Organization (2011) Safety evaluation of certain food additives and contaminants/prepared by the seventythird meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), Geneva, pp. 305-380.

EFSA Panel on Contaminants in the Food Chain (2011) Scientific Opinion: Statement on tolerable weekly intake for cadmium. EFSA J., Available from:

Moschandreas, D.J., Karuchit, S., Berry, M.R., O'rourke M.K., LO, D., Lebowitz M.D. and Robertson, G. (2002) Exposure apportionment: Ranking food items by their contribution to dietary exposure. J. Exposure Anal. Environ. Epidemiol., 12, 233-243. crossref(new window)

New Zealand Food Safety Authority (NZFSA). (2009) New Zealand total diet study (NZTDS), NZFSA, Wellington, pp.60.

Kima, M. and Wolt, J.D. (2011) Probabilistic risk assessment of dietary cadmium in the South Korean population. Food Addit. Contam. Part A Chem. Anal. Control Exposure Risk Assess., 28, 62-70. crossref(new window)

European Food Safety Authority. (2012) Scientific Report of EFSA: Cadmium dietary exposure in the European population. EFSA J., Available from: www. efsa.

Julin, B., Wolk, A., Johansson, J.E., Andersson, S.O., Andren, O. and Akesson, A. (2012) Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study. Br. J. Cancer, 107, 895-900. crossref(new window)

Centre for Food Safety (2013) The first Hong Kong total diet study: metallic contaminants. Queensway, pp. 29.

Marcussen, H., Jensen, B.H., Petersen A. and Holm, P.E. (2013) Dietary exposure to essential and potentially toxic elements for the population of Hanoi, Vietnam. Asia Pac. J. Clin. Nutr., 22, 300-311.

Chandorkar, S. and Deota, P. (2013) Heavy metal content of foods and health risk assessment in the study population of vadodara. Curr. World Environ., 8, 291-297. crossref(new window)

Yuan, X., Wang, J., Shangc, Y. and Suna, B. (2014) Health risk assessment of cadmium via dietary intake by adults in China. J. Sci. Food Agric., 94, 373-380. crossref(new window)

Norwegian Scientific Committee for Food Safety (VKM). (2015) Risk assessment of dietary cadmium exposure in the Norwegian population. Opinion of the Panel on Contaminants of the Norwegian Scientific Committee for Food Safety, VKM Report 2015:12, Oslo, pp. 49.

Simmons, R.W., Pongsakul, P., Saiyasitpanich, D. and Klinphoklap, S. (2005) Elevated levels of cadmium and zinc in paddy soils and elevated levels of cadmium in rice grain downstream of a zinc mineralized area in Thailand: Implications for public health. Environ. Geochem. Health, 27, 501-511. crossref(new window)

Swaddiwudhipong, W., Limpatanachote, P., Mahasakpan, P., Krintratun, S. and Padungtod, C. (2007) Cadmium-exposed population in Mae Sot district, Tak province: 1. Prevalence of high urinary cadmium levels in the adults. J. Med. Assoc. Thailand, 90, 143-148.

Zwicker, R., Promsawad, A., Zwicker, B.M. and Laoharojanaphand, S. (2010) Cadmium content of commercial and contaminated rice, oryza sativa, in Thailand and potential health implications. Bull. Environ. Contam. Toxicol., 84, 285-288. crossref(new window)

Sriprachote, A., Kanyawongha, P., Ochiai, K. and Matoh, T. (2015) Current situation of cadmium-polluted paddy soil, rice and soybean in the Mae Sot District, Tak Province, Thailand. Soil Sci. Plant Nutr., 58, 349-359.

Yatmark, P., Nakthong, C. and Trakranrungsie, N. (2010) Comparative evaluation of cadmium contents in livestock's kidney from Measot district, Tak province and the SW vicinity of Bangkok. Thailand J. Toxicol., 25, 81-89.

Nookabkaewa, S., Rangkadilokab, N., Akibb, C.A., Tuntiwigitc, N., Saehuna, J. and Satayavivadabd, J. (2013) Evaluation of trace elements in selected foods and dietary intake by young children in Thailand. Food Addit Contam: Part B., 6, 55-67.

Saipan, P., Tengjaroenkul, P.B. and Prahkarnkaeo, P.K. (2014) Accumulation of arsenic and cadmium in foods of animal origin collected from the local markets in northeastern region Thailand. Int. J. Anim. Vet. Adv., 6, 130-134.

Meepun, N., Saguansakbaramee, N. and Wongchuphan, R. (2014) Analysis of lead and cadmium contents in local vegetables in Surat Thani, Thailand. Walailak. J. Sci. Technol., 6, 455-461.

Kerdthep, P., Tongyonk, L., and Rojanapantip, L. (2009) Concentrations of cadmium and arsenic in seafood from Muang District, Rayong Province. J. Health Res., 23, 179-184.

Rangkadilok, N., Siripriwon, P., Nookabkaew, S., Suriyo T. and Satayavivad, J. (2015) Arsenic, cadmium, and manganese levels in shellfish from Map Ta Phut, an industrial area in Thailand, and the potential toxic effects on human cells. Arch. Environ. Contam. Toxicol., 68, 169-180. crossref(new window)

ACFS (National Bureau of Agricultural Commodity and Food Standards). (2006) Food Consumption Data of Thailand. Available from:

Swaddiwudhipong, W., Limpatanachote, P., Mahasakpan, P., Krintratun, S. and Padungtod, C. (2007) Cadmium-exposed population in Mae Sot District, Tak Province: 1. Prevalence of high urinary cadmium levels in the adults. J. Med. Assoc. Thailand, 90, 143-148.

Limpatanachote, P., Swaddiwudhipong, W., Mahasakpan, P., Krintratun, S. (2009) Cadmium-exposed population in Mae Sot District, Tak Province: 2. Prevalence of Renal dysfunction in the adults. J. Med. Assoc. Thailnad, 92, 1345-1353.

Swaddiwudhipong, W., Limpatanachote, P., Mahasakpan, P., Krintratun, S., Punta, B., Funkhiew, T. (2012) Progress in cadmium-related health effects in persons with high environmental exposure in northwestern Thailand: A five-year follow-up. Environ. Res., 112, 194-198. crossref(new window)