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Advances in the Development and Validation of Test Methods in the United States
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  • Journal title : Toxicological Research
  • Volume 32, Issue 1,  2016, pp.9-14
  • Publisher : The Korean Society of Toxicology
  • DOI : 10.5487/TR.2016.32.1.009
 Title & Authors
Advances in the Development and Validation of Test Methods in the United States
Casey, Warren M.;
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The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) provides validation support for US Federal agencies and the US Tox21 interagency consortium, an interagency collaboration that is using high throughput screening (HTS) and other advanced approaches to better understand and predict chemical hazards to humans and the environment. The use of HTS data from assays relevant to the estrogen receptor signaling data pathway is used as an example of how HTS data can be combined with computational modeling to meet the needs of US agencies. As brief summary of US efforts in the areas of biologics testing, acute toxicity, and skin sensitization will also be provided.
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Browne, P., Judson, R.S., Casey, W.M., Kleinstreuer, N.C. and Thomas, R. (2015) Screening chemicals for estrogen receptor bioactivity using a computational model. Environ. Sci. Technol., 49, 8804-8814. crossref(new window)

Judson, R.S., Magpantay, F.M., Chickarmane, V., Haskell, C., Tania, N., Taylor, J., Xia, M., Huang, R., Rotroff, D.M., Filer, D.L., Houck, K.A., Martin, M.T., Sipes, N., Richard, A.M., Mansouri, K., Setzer, R.W., Knudsen, T.B., Croffon, K.M. and Thomas, R.S. (2015) Integrated model of chemical perturbations of a biological pathway using 18 in vitro high throughput screening assays for the estrogen receptor. Toxicol. Sci., 148, 137-154. crossref(new window)

Kleinstreuer, N.C., Ceger, P.C., Allen, D.G., Strickland, J., Chang, X., Hamm, J.T. and Casey, W.M. (2015) A curated database of rodent uterotrophic bioactivity. Environ. Health Perspect., doi:10.1289/ehp.1510183. crossref(new window)

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