Advanced SearchSearch Tips
Association of the RORA Gene Polymorphism and Diurnal Preference in a Young Korean Population
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Association of the RORA Gene Polymorphism and Diurnal Preference in a Young Korean Population
Ju, Hoon; Cho, Chul-Hyun; Moon, Joung Ho; Kim, Leen; Lee, Heon-Jeong;
  PDF(new window)
Objectives: The retinoid-related orphan receptor A (RORA) gene has been reported to have an impact on circadian rhythm regulation. In this study, we analyzed the relationship between the RORA gene polymorphism and diurnal preference in Korean young adults. Methods: A population of 504 young adults was included in the study. All subjects were given and completed a 13-item composite scale for morningness (CSM). The RORA gene rs11071547 single-nucleotide polymorphism (SNP) was genotyped by PCR-based methods. Results: CSM score was not associated with genotype or allele carrier status of the RORA rs11071547 SNP. Conclusion: This result indicates that the RORA rs11071547 SNP does not play a role in diurnal preference.
Diurnal preference;Polymorphism;RORA;Morningness;
 Cited by
Adan A, Archer SN, Hidalgo MP, Di Milia L, Natale V, Randler C. Circadian typology: a comprehensive review. Chronobiol Int 2012;29:1153-1175. crossref(new window)

Liu AC, Welsh DK, Ko CH, Tran HG, Zhang EE, Priest AA, et al. Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 2007;129:605-616. crossref(new window)

Takahashi JS, Hong HK, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 2008;9:764-775. crossref(new window)

Kripke DF, Kline LE, Nievergelt CM, Murray SS, Shadan FF, Dawson A, et al. Genetic variants associated with sleep disorders. Sleep Med 2015;16:217-224. crossref(new window)

Kim HI, So SJ, Yang HJ, Song HM, Moon JH, Yoon HK, et al. Association of the RORA Gene Polymorphism and Seasonal Variations in Mood and Behavior. Sleep Med Psychophysiol 2013; 20:63-68. crossref(new window)

Kim HI, Lee HJ, Cho CH, Kang SG, Yoon HK, Park YM, et al. Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior. Chronobiol Int 2015;32:785-791. crossref(new window)

Smith CS, Reilly C, Midkiff K. Evaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. J Appl Psychol 1989;74:728-738. crossref(new window)

Greenwood KM. Long-term stability and psychometric properties of the composite scale of morningness. Ergonomics 1994;37: 377-383. crossref(new window)

Randler C, Diaz-Morales JF. Morningness in German and Spanish students: a comparative study. Eur J Person 2007;21:419-427. crossref(new window)

Yoon JS, Shin SM, Kook SH, Lee HY. A preliminary study on the Korean translation of composite scale (KtCS) to measure morningness eveningness. J Korean Neuropsychiatr Assoc 1997;36: 122-134.

Allebrandt KV, Amin N, Muller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, et al. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry 2013;18:122-132. crossref(new window)

Utge S, Kronholm E, Partonen T, Soronen P, Ollila HM, Loukola A, et al. Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women Sleep 2011;34:1309-1316. crossref(new window)