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Effects of the Particulate Matter2.5 (PM2.5) on Lipoprotein Metabolism, Uptake and Degradation, and Embryo Toxicity
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  • Journal title : Molecules and Cells
  • Volume 38, Issue 12,  2015, pp.1096-1104
  • Publisher : Korea Society for Molecular and Cellular Biology
  • DOI : 10.14348/molcells.2015.0194
 Title & Authors
Effects of the Particulate Matter2.5 (PM2.5) on Lipoprotein Metabolism, Uptake and Degradation, and Embryo Toxicity
Kim, Jae-Yong; Lee, Eun-Young; Choi, Inho; Kim, Jihoe; Cho, Kyung-Hyun;
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 Abstract
Particulate () is notorious for its strong toxic effects on the cardiovascular, skin, nervous, and reproduction systems. However, the molecular mechanism by which aggravates disease progression is poorly understood, especially in a water-soluble state. In the current study, we investigated the putative physiological effects of aqueous solution on lipoprotein metabolism. Collected from Seoul, Korea was dissolved in water, and the water extract (final 3 and 30 ppm) was treated to human serum lipoproteins, macrophages, and dermal cells. extract resulted in degradation and aggregation of high-density lipoprotein (HDL) as well as low-density lipoprotein (LDL); apoA-I in HDL aggregated and apo-B in LDL disappeared. treatment (final 30 ppm) also induced cellular uptake of oxidized LDL (oxLDL) into macrophages, especially in the presence of fructose (final 50 mM). Uptake of oxLDL along with production of reactive oxygen species was accelerated by solution in a dose-dependent manner. Further, solution caused cellular senescence in human dermal fibroblast cells. Microinjection of solution into zebrafish embryos induced severe mortality accompanied by impairment of skeletal development. In conclusion, water extract of induced oxidative stress as a precursor to cardiovascular toxicity, skin cell senescence, and embryonic toxicity via aggregation and proteolytic degradation of serum lipoproteins.
 Keywords
embryo;glycation;lipoprotein;oxidation;particulate matter 2.5;zebrafish;
 Language
English
 Cited by
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Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2.5 in human myocardial cells, Environmental Science and Pollution Research, 2017, 24, 12, 11683  crossref(new windwow)
2.
Industrial PM 2.5 cause pulmonary adverse effect through RhoA/ROCK pathway, Science of The Total Environment, 2017, 599-600, 1658  crossref(new windwow)
3.
Multi-organ toxicity induced by fine particulate matter PM 2.5 in zebrafish ( Danio rerio ) model, Chemosphere, 2017, 180, 24  crossref(new windwow)
4.
Comprehensive understanding of PM 2.5 on gene and microRNA expression patterns in zebrafish ( Danio rerio ) model, Science of The Total Environment, 2017, 586, 666  crossref(new windwow)
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