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Distribution and Features of the Six Classes of Peroxiredoxins
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  • Journal title : Molecules and Cells
  • Volume 39, Issue 1,  2016, pp.53-59
  • Publisher : Korea Society for Molecular and Cellular Biology
  • DOI : 10.14348/molcells.2016.2330
 Title & Authors
Distribution and Features of the Six Classes of Peroxiredoxins
Poole, Leslie B.; Nelson, Kimberly J.;
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Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ~3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).
active site profiling;bioinformatics;disulfide reductase;peroxide reductase;thiol peroxidase;
 Cited by
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