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Analgesic Effects of Transcranial Direct Current Stimulation on Central Neuropathic Pain in Spinal Cord Contusive Rat Model
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 Title & Authors
Analgesic Effects of Transcranial Direct Current Stimulation on Central Neuropathic Pain in Spinal Cord Contusive Rat Model
Kim, Kyung-Yoon; Sim, Ki-Chol; Kim, Hyun-Seung; Choi, Wan-Suk; Kim, Gi-Do;
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 Abstract
The aim is to investigate the analgesic effect of transcranial direct current stimulation(tDCS) on central neuropathic pain(CNP) in spinal cord contusive rat model. Twenty Sprague-Dawley rats( g, male) were used. Thoracic spinal cord(T10) was contused using New York University(NYU) spinal cord impactor. The animals were randomly assigned to two groups; GroupI: Non-treatment after SCI induction(n=10), GroupII: application of tDCS(0.1 mA, 20 min/time, 2 times/day, 5 days/6week) after SCI induction(n=10). Assess the effect of tDCS using the Basso Beattie Bresnahan(BBB) locomotor rating scales, Touch sensory evaluator(TTSE), Plantar testafter contusion at the , , , , week and the immunohistochemistric response of c-fos in the thalamus, cerebral cortex after contusion at the , week after SCI. The scores of BBB scales were significantly different from week. TTSE were different significantly over time, but there were no differences at each evaluation times on between-measure time effects. Plantar test were different significantly over time and there were difference at the , week after SCI on between-measure time effects. Also, immunohistochemistric response of c-fos was reduced significantly from , week after SCI in tDCS group compared with control group in thalamus and cortex. These results identified that tDCS of non-invasive therapeutic method may have beneficial analgesic effect on CNP after SCI with behavioral test and immunohistochemical test.
 Keywords
Contusive Spinal Cord Injury;Central Neuropathic Pain;tDCS;Anagesic Effect;c-fos;
 Language
English
 Cited by
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