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Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse
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 Title & Authors
Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse
Moon, Seongkwon;
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The heart is a major dose-limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation-induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF-, collagen type I and collagen type III was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.
Heart Fibrosis;Radiation;Tranilast;
 Cited by
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