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The Regulatory Effects of Radiation and Histone Deacetylase Inhibitor on Liver Cancer Cell Cycle
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 Title & Authors
The Regulatory Effects of Radiation and Histone Deacetylase Inhibitor on Liver Cancer Cell Cycle
Lee, Sang Ho; Han, Chang Hee; Kang, Su Man; Park, Cheol Woo;
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 Abstract
Radiation has been an effective tool for treating cancer for a long time. Radiation therapy induces DNA damage within cancer cells and destroys their ability to reproduce. Radiation therapy is often combined with other treatments, like surgery and chemotherapy. Here, we describe the effects of radiation and histone deacetylase inhibitor, Trichostain A, on cell cycle regulation in hepatoma cells. The combinatorial treatment of radiation and Trichostain A induced cell cycle arrest and thereby increasing the hepatoma cell death. Furthermore, the regulatory effects of radiation and Trichostatin A on cell cycle applied in cell type specifically. These results suggest that the treatment of radiation and Trichostatin A may play a central role in hepatoma cell death and might be a good remedy to improve the efficiency of radiation therapy.
 Keywords
radiation;Trichostatin A and liver cancer;
 Language
English
 Cited by
 References
1.
K. van Holde, and J. Zlatanova, "What determine the folding of the chromatin fiber?" Proc.Natl.Acad.Sci. U.S.A., vol. 93, no. 30, Oct. 1996, pp. 10548-10555. crossref(new window)

2.
J.L. Workman, and R.E. Kingston, "Alteration of nucleosome structure as a mechanism of transcriptional regulation," Annu.Rev.Biochem., vol. 67, Jul. 1998, pp. 545-579. crossref(new window)

3.
R.D. Kornberg, and Y. Lorch, "Twenty-five years of the nucleosome, fundamental particle of the eukatyote clrromosome," Cell, vol. 98, no. 3, Aug. 1999, pp. 285-294. crossref(new window)

4.
J.M. Espinosa, and B.M. Emerson, "Transcriptional regnlation by p53 through intrinsic DNA/chromatin binding and site-directe d cofactor recruitment," Mol.Cell, vol. 8, no. 1, Jul. 2001, pp. 57-69. crossref(new window)

5.
N.A. Barlev, L. Liu, N.H. Chehab, K Mansfield, K.G. Harris, T.D. Halazonetis, et al., "Acetylation of p53 activates transcription tlrrough recruitment of coactivatorsihistone acetyltransferases," Mol.Cell, vol. 8, no. 6, Dec. 2001, pp. 1243-1254. crossref(new window)

6.
S.L. Berger, "Histone modifications in transcriptional regnlation," Curr.Opin.Genet.Dev., vol. 12, no. 2, Apr. 2002, pp.142-148. crossref(new window)

7.
J.M. Espinosa, R.E. Verdun, and B.M. Emerson, "p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage," Mol.Cell, vol. 12, no. 4, Oct. 2003, pp.1015-1027. crossref(new window)

8.
S. Nagar, L.E. Smith, and W.F. Morgan, "Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect," Cancer Res., vol. 3, no. 2, Jan. 2003, pp. 324-328.

9.
W. An, J. Kim, and R.G. Roeder, "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53," Cell, vol. 117, no. 6, Jun. 2004, pp. 735-748. crossref(new window)

10.
A. Taddei, D. Roche, W.A. Bickmore, and G. Almouzni, "The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?" EMBO rep., vol. 6, no. 6, Jun. 2005, pp. 520-524. crossref(new window)

11.
A. Lennartsson, and K. Ekwall, "Histone modification patterns and epigenetic codes," Biochim.Biophys.Acta, vol. 1790, no. 9, Sep. 2009, pp. 863-868. crossref(new window)

12.
A. Kumar, P.S. Rai, R. Upadhya, Vishwanatha, K.S. Prasada, B.S.S. Rao, et al., "$\gamma$-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines," Int.J.Radiat.Biol., vol. 87, no. 11, Nov. 2011, pp. 1086-1096. crossref(new window)