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Characterization of Growth Hormone Secretion to Growth Hormone releasing Peptide-2 in Domestic Animals - A Review
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 Title & Authors
Characterization of Growth Hormone Secretion to Growth Hormone releasing Peptide-2 in Domestic Animals - A Review
Roh, Sang-Gun; Lee, Hong-Gu; Phung, Long Thang; Hidari, Hisashi;
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Growth hormone-releasing peptide-2 (GHRP-2, also named KP102) is a new hexapeptide of a series of synthetic growth hormone-releasing peptides (GHRPs) which stimulates the secretion of growth hormone (GH) in vitro and in vivo in several species including calf, sheep and pig. The GH-releasing activity of GHRP-2 is two to three times more effective than that of the original GHRP-6, and GHRP-1 in the rats and humans. To date, GHRP-2 seems to be the most potent member of the family of GHRPs. Since the GHRPs are short peptides (5-7 amino acid residues), they are synthesized easily and are not as readily degraded in plasma as GHreleasing hormone (GHRH). These features ameliorate their potential on domestic animals because of their chemical nature the GHRPs are efficacious when administered i.v. orally or orally. However, studies in cow, pig and sheep do not indicate such a close relationship between GHRH, somatostatin (SS) and GH, calling into question the general applicability of the human and rat models. Perhaps there is an important role for an endogenous GHRP in the regulation of GH secretion in domestic animals. This review provides an overview on the current knowledge of physiological role of GHRP-2 in domestic animals.
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Armstrong, J. D., W. S Cohick, R. W. Harvey, E. P. Heimer and R. M. Campbell. 1993. Effect of feed restriction on serum somatotropin, insulin-like growth factor-I-(IGF-I) and IGF binding proteins in cyclic heifers actively immunized against growth hormone releasing factor. Domest. Anim. Endocrinol. 10:315-324. crossref(new window)

Badger, T. M., W. J. Millard, G. F. McCormick, C. Y. Bowers and J. B. Martin. 1984. The effects of growth hormone(GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats. Endocrinology 115:1432-1438. crossref(new window)

Baker, P. K., S. D. Conner, M. E. Doscher, L. A. Kraft and C. A. Ricks. 1984. Use of a synthetic growth hormone releasing hexapeptide to increase rate of gain in rats. J. Anim. Sci. 59(Suppl.):220(Abstr.).

Bowers, C. Y., D. K. Alster and J. M. Frentz. 1992. The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short statured children after oral administration. J. Clin. Endocrinol. Metab. 74:292-298. crossref(new window)

Bowers, C. Y., F. A. Momany, G. A. Reynolds and A. Hong. 1984. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114:1537-1545. crossref(new window)

Bowers, C. Y., G. A. Reynolds, D. Durham, C. M. Barrera, S. S. Pezzoli and M. O. Thorner. 1990. Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J. Clin. Endocrinol. Metab. 70:975-982. crossref(new window)

Bowers, C. Y., A. O. Sartor, G. A. Reynolds and T. M. Badger. 1991. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 128:2027-2035. crossref(new window)

Bowers, C. Y. 1993. GH releasing peptides-structure and kinetics. J. Pediatr. Endocrinol 6:21-31.

Buonomo, F. C. and C. A. Baile. 1990. The neurophysiological regulation of growth hormone secretion. Domest. Anim. Endocrinol. 7:435-450. crossref(new window)

Camacho-Hubner, C., R. H. McCusker and D. R. Clemmons. 1991. Secretion and biological actions of insulin-like growth factor binding proteins in two human tumor-derived cell lines in vitro. J. Cell Physiol. 148:281-9. crossref(new window)

Chen, C., D. Wu and I. J. Clark. 1996. Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. J. Endocrinology 148:381-386. crossref(new window)

Cheng, K., W. W. -S. Chan, B. Butler, L. Wei, W. R. Schoen, M. J. Jr. Wyvratt, M. H. Fisher and R. G. Smith. 1993. Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue Endocrinology 132(6):2729-2731. crossref(new window)

Cheng, K., W. W. -S. Chan, A. Jr. Barreto, E. M. Convey and R. G. Smith. 1989. The synergistic effects of His-D-Trp-Ala-Trp-DPhe-Lys-NH2 on growth hormone (GH)-releasing factorstimulated GH release and intracellular adenosine 3',5'-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124:2791-2798. crossref(new window)

Clark, R. G., L. M. S. Carlsson, J. Trojnar, and I. C. A. F. Robinson. 1989. The effect of a growth hormone-releasing peptide and growth hormone-releasing factor in conscious anaesthetized rats. J. Neuroendocrinology 1:249-255. crossref(new window)

Codd, E. E., A. Y. L. Shu and R. F. Walker. 1989. Binding of a growth hormone releasing hexapeptide to specific hypothalamus and pituitary binding sites. Neuropharmacology 28:1139-1144. crossref(new window)

Cohick, W. S., J. D. Armstrong, M. D. Whitacre, M. C. Lucy, R. W. Harvey and R. M. Campbell. 1996. Ovarian expression of insulin-like growth factor-I (IGF-I), IGF binding proteins, and growth hormone (GH) receptor in heifers actively immunized against GH-releasing factors. Endocrinology 137:1670-1677. crossref(new window)

Cohick, W. S., M. A. McGuire, D. R. Clemmons and D. E. Bauman. 1992. Regulation of insulin-like growth factorbinding proteins in serum and lymph of lactating cows by somatotropin. Endocrinology 1992;130:1508-1514. crossref(new window)

Cohick, W. S., K. Plaut, S. J. Sechen and D. E. Bauman. 1989. Temporal pattern of insulin-like growth factor-1 response to exogenous bovine somatotropin in lactating cows. Domest. Anim. Endocrinol. 6:263-273. crossref(new window)

Conley, L. K., J. A. Teik, R. Deghenghi, B. P. Imbimbo, A. Guistina, V. Locatelli and W. B. Wehrenberg. 1995. Mechanism of action of hexarelin and GHRP-6 : Analysis of the involvement of GRF and somatostatin in the rat. Neuroendocrinology 61:44-50. crossref(new window)

Conway, S., L. Richardson, S. Speciale, R. Moherek, H. Mauceri and L. Krulich. 1990. Interaction between norepinephrine and serotonin in the neuroendocrine control of groth homorne release in the rat. Endocrinology 126:1022-1030. crossref(new window)

Debell, W. K., S. S. Pezzoli and M. O. Thorner. 1991. Growth hormone (GH) secretion during continuous infusion of GHreleasing peptide: partial response attenuation. J. Clin. Endocrinol. Metab. 72:1312-1316. crossref(new window)

Della-Fera, M. A., F. C. Buonomo and C. A. Baile. 1986. Growth hormone secretory responsiveness to multiple injections of growth hormone-releasing factor in sheep. Domest. Anim. Endocrinol. 3:153-164. crossref(new window)

Dickson, S. L., G. Leng, R. E. Dyball and R. G. Smith. 1995. Central actions of peptide and non-peptide growth hormone secretagogues in the rat. Neuroendocrinology 61:36-43. crossref(new window)

Doscher, M. E., P. K. Baker, L. A. Kraft and C. A. Ricks. 1984. Effects of a synthetic growth hormone releasing hexapeptide (BI 679) and growth hormone releasing factor (GRF) on serum growth hormone levels in barrows. J. Anim. Sci. 59(Suppl.):218(Abstr.).

Dubreuil, P., D. Petitclerc, G. Pelletier, P. Gaudreau, C. Farmer, T. F. Mowles and P. Brazeau. 1990. Effect of dose and frequency of administration of a potent analog of human growth hormone-releasing factor on hormone secretion and growth in pigs. J. Anim. Sci. 68:1254-1268.

Enright, W. J., L. T. Chapin, W. M. Moseley, S. A. Zinn, M. B. Kamdar, L. F. Krabill and H. A. Tucker. 1989. Effects of infusions of various doses of bovine growth hormone-releasing factor on blood hormones and metabolites in lactating Holstein cows. J. Endocrinology 122:671-679. crossref(new window)

Fletcher, T. P., G. B. Thomas and I. J. Clarke. 1996. Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. Domest. Anim. Endocrinol. 13:251-256. crossref(new window)

Fletcher, T. P., G. B. Thomas, J. O. Willoghby and I. J. Clarke. 1994. Constitutive growth hormone secretion in sheep after hypothalamopituitary disconnection and the direct in vivo pituitary effect of growth hormone releasing peptide 6. Neuroendocrinology 60:76-86. crossref(new window)

Frohman, L., T. Downs, I. Clark I and G. Thomas. 1990. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep: Spontaneous secretion and response to insulin-induced hypoglycemia. J. Clin. Invest. 86:17-24. crossref(new window)

Gallaher, B. W., B. H. Breier, W. F. Blum, S. N. McCutcheon and P. D. Gluckman. 1995. A homologous radioimmunoassay for ovine insulin-like growth factor-binding protein-2: Ontogenesis and the response to growth hormone, placental lactogen and insulin-like growth factor-1 treatment in sheep. J. Endocrinology 144:75-82. crossref(new window)

Gallaher, B. W., B. H. Breier, M. H. Oliver, J. E. Harding and P. D. Gluckman. 1992. Ontogenic differences in the nutritional regulation of circulating IGF binding proteins in sheep plasma. Acta Endocrinol. 126:49-54.

Gaynor, P. J., C. R. Simmons, K. J. Lookingland and H. A. Tucker. 1996. 5-hydroxytryptaminergic receptor-mediated regulation of growth hormone secretion in Holstein steers occurs via a2-adrenergic-dependent and -independent mechanisms. Proc. Soc. Exp. Biol. Med. 212:355-361.

Gertz, B. J., J. S. Barrett, R. Eisenhandler, D. A. Krupa, J. M. Wittreich, J. R. Seibold and S. H. Schneider. 1993. Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6.J. Clin. Endocrinol. Metab. 77:1393-1397. crossref(new window)

Ghigo, E., E. Arvat, L. Gianotti, B. P. Imbimbo, V. Lenaerts, R. Deghenghi and F. Camanni. 1994. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man. J. Clin. Endocrinol. Metab. 78:693-698. crossref(new window)

Ghigo, E., E. Arvat, G. Rizzi, S. Goffi, S. Grottoli, M. Mucci, M. F. Boghen and F. Camanni. 1994. Growth hormone releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging. Eur. J. Endocrinol. 131:499-503. crossref(new window)

Ghigo, E., E. Arvat, L. Gianotti, S. Grottoli, G. Rizzi, G. P. Ceda, M. F. Boghen, R. Deghenghi and F. Camanni. 1996. Shortterm administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging. Eur. J. Endocrinol. 135:407-412. crossref(new window)

Goth, M. I., C. E. Lyons, B. J. Canny and M. O. Thorner. 1992. Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct receptors. Endocrinology 130:939-944. crossref(new window)

Guler, H. P, J. Zapf, C. Schmid and E. R. Froesch. 1989. Insulinlike growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol. 121:753-758.

Hart, I. C., P. M. E. Chadwick, A. Coert, S. James and A. D. Simmonds. 1985. Effect of different growth hormone-releasing factors on the concentrations of growth hormone, insulin and metabolites in the plasma of sheep maintained in positive and negative energy balance. J. Endocrinology 105:113-119. crossref(new window)

Hartman, M. L., G. Farello, S. S. Pezzoli and M. O. Thorner. 1992. Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. J. Clin. Endocrinol. Metab. 74:1378-1384. crossref(new window)

Hashizume, T., M. Kawai, K. Ohtsuki, A. Ishii and M. Numata. 1999. Oral administration of peptidergic growth hormone (GH) secretagogue KP102 stimulates GH release in goats. Domest. Anim. Endocrinol. 16:31-39. crossref(new window)

Hashizume, T., K. Sasaki, M. Sakai, S. Tauchi and H. Masuda. 1997a. The effect of new growth hormone–releasing peptide (KP102) on the release of growth hormone in goats. Anim. Sci. Technol. (Japan) 68:247-256.

Hashizume, T., M. Yanagimoto, S. Kainuma, R. Nagano, K. Moriwaki, K. Ohtsuki, K. Sasaki, H. Masuda and T. Hirata. 1997b. Effect of new growth hormone–releasing peptide (KP102) on the release of growth hormone in vitro and in vivo in cattle. Anim. Sci. Technol. (Japan) 68:450-458.

Hickey, G., T. Jacks, F. Judith, J. Taylor, W. R. Schoen, D. Krupa, P. Cunningham, J. Clark and R. G. Smith. 1994. Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue in beagles. Endocrinology 134:695-701. crossref(new window)

Hodgkinson, S. C., J. J. Bass and P. D. Gluckman. 1991. Plasma IGF-1 binding proteins in sheep: effect of recombinant growth hormone treatment and nutritional status. Domest. Anim. Endocrinol. 8:343-351. crossref(new window)

Howard, A. D., S. D. Feighner, D. F. Cully, J. P. Arena, P. A. Liberator, C. I. Rosenblum, M. Hamelin, D. L. Hreniuk, O. C. Palyha, J. Anderson, P. S. Paress, C. Diaz, M. Chou, K. K. Liu, K. K. McKee, S. S. Pong, L. Y. Chaung, A. Elbrecht, M. Dashkevicz, R. Heavens, M. Rigby, D. J. S. Sirinathsinghii, D. C. Dean, D. G. Melillo, A. A. Patchett, R. Nargund, P. R. Griffin, J. A. DeMartino, S. K. Gupta, J. M. Schaeffer, R. G. Smith and L. H. T. Van der Ploeg. 1996. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977. crossref(new window)

Huhn, W. C., M. L. Hartman, S. S. Pezzoli and M. O. Thorner. 1993. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J. Clin. Endocrinol. Metab. 76:1202-1208. crossref(new window)

Jacks, T., G. Hickey, F. Judith, J. Taylor, H. Chen, D. Krupa, W. Feeney, W. Schoen, D. Ok, M. Fisher, M. Wyvratt and R. Smith. 1994. Effects of acute and repeated intravenous of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-I, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J. Endocrinology 143:399-406. crossref(new window)

Jaffe, C. A., P. J. Ho, R. Demott-friberg, C. Y. Bowers and A. L. Barkan. 1993. Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. J. Clin. Endocrinol. Metab. 77:1641-1647. crossref(new window)

Johnson, D. W., M. A. Barner, R. M. Akers and R. E. Pearson. 1993. A synthetic opioid peptide increases plasma growth hormone and prolactin in Holstein calves. J. Anim. Sci. 71:1004-1009.

Kirby, C. J., J. D. Armstrong, B. G. Huff, R. L. Stanko, R. W. Harvey, E. P. Heimer and R. M. Campbell. 1993. Changes in serum somatotropin, somatotropin mRNA, and serum and follicular insulin-like growth factor-I in response to feed restriction in cows actively immunized against growth hormone-releasing factor. J. Anim. Sci. 71:3033-3042.

Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matsuo and K. Kangawa. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660. crossref(new window)

Kraft, L. A., P. K. Baker, M. E. Doscher and C. A. Ricks. 1984. Effects of a synthetic growth hormone releasing hexapeptide on serum growth hormone levels in steers. J. Anim. Sci. 59(Suppl.):218(Abstr.).

Lau, Y. S., A. M. Camoratto, L. M. White and C. M. Moriartu. 1991. Effect of lead on TRH and GRF binding in rat anterior pituitary membranes. Toxicology 68:169-179. crossref(new window)

Lee, H. G., R. A. Vega, L. T. Phung, N. Matsunaga, H. Kuwayama and H. Hidari. 2000. The effect of growth hormone-releasing peptide-2 (KP102) administration on plasma insulin-like growth factor (IGF)-1 and IGF-binding proteins in Holstein steers on different planes of nutrition. Domest. Anim. Endocrinol. 18:293-308. crossref(new window)

Locatelli, V., A. Tosello, M. Readaelli, E. Ghigo, F. Massara and E. E. Muller EE. 1986. Cholinergic agonist drugs modulate the growth hormone response to growth hormone releasing hormone in the rats: evidence fro mediation by somatostatin. J. Endocrinology 111:271-275. crossref(new window)

Locke, W., H. D. Kirgis, C. Y. Bower and A. A. Abdoh. 1995. Intracerebroventricular growth hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. Life Sci. 56:1347-1352. crossref(new window)

Masuda, Y., T. Tanaka, N. Inomata, N. Ohnuma, S. Tanaka, Z. Itoh, H. Hosoda, M. Kojima and K. Kangawa. 2000. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 276:905-908. crossref(new window)

McFadden, T. B., T. E. Daniel and R. M. Akers. 1990. Effects of plane of nutrition, growth hormone and unsaturated fat on growth hormone, insulin and prolactin receptors in prepubertal lambs. J. Amin. Sci. 68:3180-3189.

McMahon, C. D., L. T. Chapin, K. J. Lookingland, R. P. Radcliff and H. A. Tucker. 1999. Feeding-induced increases in insulin do not suppress secretion of growth hormone. Domest. Anim. Endocrinol. 17:439-447. crossref(new window)

Momany, F. A., C. Y. Bowers, G. A. Reynolds, A. Hong and K. Newlander. 1984. Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology 114:1531-1536. crossref(new window)

Moseley, W.M., G.R. Alaniz, W.H. Claflin, and L.F. Krabill. 1988. Food intake alters serum growth hormone response to bovine growth hormone-releasing factor in meal-fed Holstein steers. J. Endocrinology 117:253-259. crossref(new window)

Murakami, Y., K. Kato, Y. Kabayama, K. Tojo, T. Inoue and H. Imura. 1986. Involvement of growth hormone (GH)-releasing factor in GH secretion induced by serotonergic mechanisms in conscious rats. Endocrinology 119:1089-1092. crossref(new window)

Muruais, J., A. Penalva, C. Dieguez and F. F. Casanueva. 1993. Influence of endogenous cholinergic tone and a-adrenergic pathways on growth hormone responses to His-D-Trp-Ala-Trp-D-Phe-Lys-$NH_2$ in the dog. J. Endocrinology 138:211-218. crossref(new window)

Muller, E. 1987. Neural control of somatotropic function. Physiol. Rev. 67:962-1053.

Newbold, J. A., R. B. Heap, C. G. Prosser, R. H. Phipps, F. Adriaens and D. L. Hard. 1997. The effect of bovine somatotropin and diet on somatotropin binding sites in hepatic tissue of lactating dairy cows. J. Dairy Sci. 80:1085-1091.

Nijland, E. A., C. J. Strasburger, C. Popp-Snijders, P. S. Van der Wal and E. A. Van der Veen. 1998. A five day treatment with daily s.c. injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-1 secretion in healthy young men. Eur. J. Endocrinol. 139:395-401. crossref(new window)

Okada, K., S. Ishii, S. Minami, T. Shibasaki and I. Wakabayashi. 1996. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology 137:5155-5158. crossref(new window)

Patchett, A. A., R. P. Nargund, J. R. Tata, M. H. Chen, K. J. Barakat, D. B. Johnston, K. Cheng, W. W. Chan, B. Butler and G. Hickey. 1995. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc. Natl. Acad. Sci. 92(15):7001-7005. crossref(new window)

Petitclerc, D., G. Pelletier, H. Lapierre, P. Gaudreau, Y. Couture, P. Dubreuil, J. Morisset and P. Brazeau. 1987. Dose response of two synthetic human growth hormone-releasing factors on growth hormone release in heifer and pigs. J. Anim. Sci. 65:996-1005.

Penalva, A., A. Carballo, M. Pombo, E. F. Casanueva and C. Dieguez C. 1993. Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man. J. Clin. Endocrinol. Metab. 76:168-171. crossref(new window)

Phung, L. T., A. Sasaki, H. G. Lee, R. A. Vega, N. Matsunaga, S. Hidaka, H. Kuwayama and H. Hidari. 2001. Effects of the administration of growth hormone-releasing peptide-2 (GHRP-2) orally by gavage and in feed ongrowth hormone release in swine. Domest. Anim. Endocrinol. 20:9-19. crossref(new window)

Phung, L. T., H. Inoue, V. Nou, H. G. Lee, R. A. Vega, N. Matsunaga, S. Hidaka, H. Kuwayama and H. Hidari. 2000. The effects of growth hormone-releasing peptide-2 (GHRP-2) on the releasing of growth hormone and growth performance in swine. Domest. Anim. Endocrinol 18:279-291. crossref(new window)

Pong, S. S., L. Y. P. Chaung, D. C. Dean, R. P. Nargund, A. A. Patchett and R. G. Smith. 1996. Identification of a new Gprotein linked receptor for growth hormone secretagogues. Mol. Endocrinol. 10:57-61. crossref(new window)

Rajaram, S., D. J. Baylink and S. Mohan. 1997. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocrine Review 18:801-831. crossref(new window)

Rigamonti, A. E., S. G. Cella, N. Marazzi and E. E. Muller. 1999. Six-week treatment with hexarelin in young dogs: evaluation of the GH responsiveness to acute hexarelin or GHRH administration, and of the orexigenic effect of hexarelin. Eur. J. Endocrinology 41:313-320. crossref(new window)

Roberts, A. J., R. A. Nugent, J. Klindt and T. G. Jenkins. 1997. Circulating insulin-like growth factor I, insulin-like growth factor binding proteins, growth hormone, and resumption of estrus in postpartum cows subjected to dietary energy restriction. J. Anim. Sci. 75:1909-1917.

Roh, S. G., M. L. He, N. Matsunaga, S. Hidaka and H. Hidari. 1997a. Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J. Anim. Sci. 75:2744-2748.

Roh, S. G., M. L. He, N. Matsunaga, S. Hidaka and H. Hidari. 1997b. No desensitization of the growth hormone (GH) response between GH-releasing peptide-2 and GH-releasing factor in calves. J. Anim. Sci. 75:2749-2753.

Roh, S. G., M. Hirota, M. L. He, N. Matsunaga, S. Hidaka and H. Hidari. 1997c. Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormonereleasing hormone (GHRP-2) in ovariectomized ewes. Endocrine J. 44:861-865. crossref(new window)

Roh, S. G., N. Matsunaga, S. Hidaka and H. Hidari. 1996. Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocrine J. 43:291-298. crossref(new window)

Ross, R. J., M. Tsagarakis, A. Grossman and G. M. Besser. 1987. GH feed-back occurs through modulation of hypothalalmic somatostatin under cholinergic control:studies with pyridostigmine and GHRH. Clinical Endocrinology 27:727- 732. crossref(new window)

Sartin, J. L., R. J. Kemppainen, D. N. Marple, R. Varnes, G. Dieberg and E. H. Oliver. 1987. Effects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steers. Domest. Anim. Endocrinol. 4:33-41. crossref(new window)

Sartor, O., C. Y. Bowers, G. A. Reynolds and F. A. Momany. 1985. Variables determining the growth hormone response of His-D-Trp-Ala-Trp-D-Phe-Lys-$NH_2$ in the rat. Endocrinology 117:1441-1447. crossref(new window)

Sawada, H., H. Sugihara, H. Onose, S. Minami, T. Shibasaki and I. Wakabayashi. Effect of D-Ala-D-$\beta$Nal-Ala-Trp-D-Phe-Lys-$\NH_2$ (KP-102) on GH secretion in urethan-anesthetized rats. Regul. Peptides 53:195-201. crossref(new window)

Simpson, R. B., J. D. Armstrong and R. W. Harvey. 1992. Effect of prepartum administration of growth hormone releasing factor on somatotropin, insulin-like growth factor I, milk production and postpartum return to ovarian activity in primiparous beef heifers. J. Anim. Sci. 70:1478-1487.

Smith, R. G., K. Cheng, W. R. Schoen, S. S. Pong, G. Hickey, T. Jacks, B. Butler, W. W. Chan, L. Y. Chaung and F. Judith et al. 1993. A nonpeptidyl growth hormone secretagogue. Science. 260:1640-1643. crossref(new window)

Torsello, A., M. Luoni, F. Schweiger, R. Grilli, M. Guidi, E. Bresciani, R. Deghenghi, E. E. Muller and V. Locatelli. 1998. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Eur. J. Pharmacol. 360:123-129. crossref(new window)

Trenkle, A. 1998. Influence of feeding on growth hormone secretion and response to growth hormone-releasing factor in sheep. J. Nutr. 1989;119:61-65.

Van den Berghe, G., P. Wouters, C. Y. Bowers and F. de Zegher. 1999. R. Bouillon. Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness. Eur. J. Endocrinol. 140:17-22. crossref(new window)

Vicini, J. L., F. C. Buonomo, J. J. Veenhuizen, M. A. Miller, D. R. Clemmons and R. J. Collier. 1991. Nutrient balance and stageof lactation affect responses of insulin, insulin like growth factors 1 and 2, and insulin-like growth factor-binding protein 2 to somatotropin administration in dairy cows. J. Nutr. 121:1656-1664.

Walker, R. F., E. E. Cold, F. C. Barone, A. H. Nelson, T. Goodwin and S. A. Campbell. 1990. Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-$NH_2$ in rats, dogs and monkeys. Life Sci. 47:29-36. crossref(new window)

Willoughby, J. O., M. F. Menadue and H. Liebelts. 1987. Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat. Brain Res. 404:319-322. crossref(new window)

Wu, D., C. Chen, K. Katoh, J. Zhang and I. J. Clarke. 1994a. The effect of GH-releasing peptide-2 (GHRP-2 or KP102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. J. Endocrinology 140:R9-13. crossref(new window)

Wu, D., C. Chen, K. Katoh, J. Zhang and I. J. Clarke. 1994b. Effects in vitro of growth hormone-releasing factor (GRF) and growth hormone releasing peptide (GHRPs) on growth hormone secretion from ovine pituitary cells in primary culture. J. Neuroendocrinology 6:185-190. crossref(new window)

Wu, D., C. Chen, J. Zhang, C. Y. Bowers and I. J. Clarke. 1996. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. J. Endocrinology 148:197-205. crossref(new window)