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Esterified-Glucomannan in Broiler Chicken Diets-Contaminated with Aflatoxin, Ochratoxin and T-2 Toxin: Evaluation of its Binding Ability (in vitro) and Efficacy as Immunomodulator
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 Title & Authors
Esterified-Glucomannan in Broiler Chicken Diets-Contaminated with Aflatoxin, Ochratoxin and T-2 Toxin: Evaluation of its Binding Ability (in vitro) and Efficacy as Immunomodulator
Raju, M.V.L.N.; Devegowda, G.;
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 Abstract
In vitro binding efficacy of esterified glucomannan (E-GM) (0.1%) on aflatoxin B1 (AF) (300 ppb), ochratoxin A (OA) (2 ppm) and T-2 toxin (T-2) (3 ppm), when present alone or in combination, was evaluated in toxin-contaminated feed at pH 4.5 and 6.5. Esterified glucomannan showed significantly (p<0.01) higher binding with AF (81.6%), whereas those recorded with T-2 (27.8%) and OA (25.6%) were moderate. Binding of each toxin decreased as the number of toxins in feed increased. pH of medium showed no effect on mycotoxin binding ability of E-GM. A factorial experiment of 5 week duration was conducted to study the effects of two dietary levels each of AF (0 and 300 ppb), OA (0 and 2 ppm), T-2 (0 and 3 ppm ) and E-GM (0 and 0.1%) on the immune competence of a total of 960 day-old commercial broilers. Reductions in size of thymus (by AF and T-2) and bursa (by AF) and antibody titers against Newcastle disease and Infectious Bursal disease (by all the toxins) were noted. Additive and antagonistic interactions were seen among the toxins on certain parameters. Esterified glucomannan significantly (p<0.01) improved antibody titers and weights of bursa ofFabricius and thymus indicating its counteracting efficacy against immunosuppression in mycotoxicosis of multiple origin.
 Keywords
Esterified-Glucomannan;Aflatoxin;Ochratoxin;T-2 Toxin;Broilers;
 Language
English
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 References
1.
AOAC. 1995. Official Methods of Analysis. 16th edn. Association of Official Analytical Chemists, Washington, DC.

2.
BIS. 1992. Indian standard specification for poultry feeds :IS:1374-1979. Bureau of Indian Standards, Manak Bhavan, New Delhi.

3.
Burmeister, H. R. 1971. T-2 Toxin production by Fusarium tricinctum on solid substrate. Appl. Microbiol. 21:739-742.

4.
Cotter, P. F. and J. Weinner. 1997. Bio-MOS modulates the phytohaemagglutinin wattle reaction in commercial pullets. In Proceedings of the 18th Annual Meeting of Southern Poultry Science Society, Atlanta, GA, S36(Abstr.).

5.
Devegowda, G., B. I. R. Aravind, K. Rajendra, M. G. Morton, A. Baburathna and C. Sudharshan. 1994. A Biological approach to counteract aflatoxicosis in broiler chickens and duckings by the use of Saccharomyces cerevisiae cultures added to feed. In: Biotechnology in the Feed Industry (Ed. T. P. Lyons and K. A. Jaques). Proceedings of the Alltech's 10th Annual Symposium, Kentucky, pp. 235-245.

6.
Duncan, D. B. 1955. Multiple range and multiple F tests. Biometrics 11:1-42. crossref(new window)

7.
Dvorska, J. E. and P. F. Surai. 2001. Effects of T-2 toxin, zeolite and Mycosorb on antioxidant systems of growing quail. Asian-Aust. J. Anim. Sci. 14:1752-1757.

8.
Dwivedi, P. and R. B. Burns. 1984. Pathology of ochratoxicosis A in young broiler chicks. Res. Vet. Sci. 36:92-103.

9.
Edrington, T. S., L. F. Kubena, R. B. Harvey and G. E. Rottinghaus. 1997. Influence of superactivated charcoal on the toxic effects of aflatoxin or T-2 toxin in growing broilers. Poult. Sci. 76:1205-1211.

10.
Hoerr, F. J., W. W. Carlton and B. Yagen. 1981. Mycotoxicosis caused by a single dose of T-2 toxin or diacetoxyscirpenol in broiler chickens. Vet. Path. 18:652-664.

11.
Huff, W. E. and J. A. Doerr. 1981. Synergism between aflatoxin and ochratoxin in broiler chickens. Poult. Sci. 60:550-555.

12.
Huff, W. E., L. F. Kubena, R. B. Harvey and T. D. Philips. 1992. Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A. Poult. Sci. 71:64-69.

13.
Lyons, T. P. 1994. 1994 and beyond. In: Biotechnology in the Feed Industry (Ed. T. P. Lyons and K. A. Jaques). Proceedings of the Alltech's 10th Annual Symposium, Kentucky, pp. 1-48.

14.
Pasteiner, S. 1997. Coping with mycotoxin contaminated feed stuffs. Feed International 18(5):12-16.

15.
Raju, M. V. L. N. and G. Devegowda. 2000. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). Br. Poult. Sci. 41:640-650. crossref(new window)

16.
Romer, T. R., T. M. Boling and J. L. Mac Donald. 1978. Gas-liquid chromatographic determination of T-2 toxin and diacetoxyscirpenol in corn and mixed feeds. J. Assoc. Off. Anal. Chem. 6:801-807.

17.
Rukmini, C. and R. V. Bhat. 1978. Occurrence of T-2 toxin in Fusarium infested sorghum from India. J. Agric. Food Chem. 26:647-649. crossref(new window)

18.
SAS Institute Inc. 1994. SAS User' guide : Statistics, version 6.12. SAS Institute Inc., Cary, North Carolina.

19.
Savage, T. F., P. F. Cotter and E. I. Zakrzewska. 1996. The effect of feeding mannanoligosaccharide on immunoglobulins, plasma IgG and bile IgA of Worldstad MW male turkeys. Poult. Sci. 75(Suppl. 1):143.

20.
Shotwell, O. L., C. W. Hesseltine, R. D. Stubblefield and W. E. Sorenson. 1966. Production of aflatoxin on rice. Appl.Microbiol. 14:425-428.

21.
Stanley, V. G., R. Ojo, S. Woldensenbet and D. H. Hutchinson. 1993. The use of Saccharomyces cerevisiae to suppress the effects of aflatoxicosis in broiler chicks. Poult. Sci. 72:1867-1872.

22.
Trenk, H. L., M. E. Butz and F. S. Chu. 1971. Production of ochratoxin in different cereal products by Aspergillus ochraceus. Appl. Microbiol. 21:1032-1035.

23.
Verma, J., T. S. Johri, A. K. Shrivastav and S. Majumdar. 1995. Studies on the effect of dietary aflatoxin, ochratoxin and their combinations in broilers-Radio isotopic and immunological studies. In: Proceedings of the 17th Annual Symposium of Indian Poultry Sci. Assn., Bangalore, P 04(Abstr.).