JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Influence of 2-bromo-α-ergocryptine on Plasma Prolactin, Oestradiol-17β and Progesterone Levels in Domestic Hen
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Influence of 2-bromo-α-ergocryptine on Plasma Prolactin, Oestradiol-17β and Progesterone Levels in Domestic Hen
Reddy, I.J.; David, C.G.; Singh, Khub;
  PDF(new window)
 Abstract
This study investigated the effect of 2-bromo--ergocryptine (anti prolactin agent) on plasma levels of prolactin, oestradiol-17 and progesterone in domestic hen during the active period of lay. Fifty healthy female White Leghorn birds were administered with anti prolactin agent (2-bromo--ergocryptine, Sigma-USA., methane sulphonate salt, ) subcutaneously body weight at weekly intervals from 17th to 36th week of age. Another group of fifty birds as controls were given placebo in place of bromocriptine. The level of prolactin remained lower in treated birds than in the control birds from 19 to 36 weeks of age. Level of prolactin even in the control group was found to decrease during the peak production period. Oestradiol- and progesterone concentration in treated birds were significantly (p<0.01) higher than the controls during the treatment. Egg production, is positively correlated with oestradiol- (r=0.02; r=0.67) and progesterone (r=0.49; r=0.90) in control and treated groups respectively where as prolactin level is positively correlated with egg production in the control birds (r=0.07). Prolactin levels were negatively correlated with egg production (r=-0.55) in treated birds; and oestradiol- (r =-0.71; r=-0.53) and progesterone (r=-0.22; r=-0.27) respectively in control and treated groups. The total number of pause days during the treatment period decreased significantly (p<0.01) in the treated group compared to the control group. The reduction in pause days in treated group resulted in 1.76% increase in egg production over that in control group. The increase in egg laying days and the total egg production were found to be significant (p<0.01). These results indicate that a lower level of prolactin in circulatory blood enhances egg production in the domestic hen.
 Keywords
Sequence Length;Prolactin;Oestradiol;Progesterone;Domestic Hen;
 Language
English
 Cited by
 References
1.
Burke, W. H. and P. T. Dennison. 1980. Prolactin and luteinizing hormone levels in female turkeys during induced reproductive cycle and broodiness. General and Comparative Endocrinology 41:92-100. crossref(new window)

2.
Burke W. H., P. T. Dennison, J. L. Silsby and M. E. El Halawani. 1981. Serum prolactin levels of turkey hens in relation to reproductive function. Advances in Physiological Sciences. 3:109-116.

3.
Camper, P. M. and W. H. Burke. 1977. Effects of prolactin on the gonadotrophin induced rise in serum oestradiol and progesterone in the laying turkey. General and Comparative Endocrinology 32:72-77. crossref(new window)

4.
Chen, S., M. J. Besman, R. S. Sparkes, S. Zollman, I. Klisak, T. Mohandas, P. F. Hall and J. E. Shively. 1988. Human aromatase: cDNA cloning, southern analysis and assignment of the gene to chromosome 15. DNA 7:27-38. crossref(new window)

5.
Crisostomo, S., D. Guemene, M. Gaeerean, Mills, C. Morvah and D. Zadworny. 1998. Prevention of incubation behaviour expression in turkey hens by active immunization against prolactin. Theriogenology 50:675-690. crossref(new window)

6.
Dajee, M., G. H. Fely and J. S. Richards. 1998. Stat 5b and the orphan nuclear receptors regulate expression of the alpha 2-microglobin (alpha 2M) gene in rat ovarian granulose cells. Molecular Endocrinology 12:1393-1409. crossref(new window)

7.
Dorrington, J. H. and R. E. Gore-Langton. 1981. Prolactin inhibits estrogen synthesis in the ovary. Nature 290:600-602. crossref(new window)

8.
Dunaif, A. E., E. A. Zimmerman, H. G. Fresen and A. Frantz. 1982. Intracellular localization of protection receptor and Prolactin in the rat ovary by immunocytochemistry. Endocrinology, 110:14 65-71. crossref(new window)

9.
El Halawani, M. E., J. L. Silsby, L. K. Foster, I. Rosenboim and D. N. Foster. 1993. Ovarian environment in the suppression of Leutinizing hormone in the incubated turkey. Neuroendocrinology 58:35-41. crossref(new window)

10.
El Halawani, M. E., S. Fehrer, B. M. Hargis and T. E. Porter. 1988. Incubation behavior in the domestic turkey: Physiological correlates. CRC Critical Reviews in Poultry Biology. 1:285-314.

11.
El Halawani, M. E., W. H. Burke and P. T. Dennison. 1980. Effect of nest deprivation on serum prolactin levels in nesting female turkeys. Biology of Reproduction 23:815-819. crossref(new window)

12.
Emmerson, D. A., D. M. Denbow, H. P. Krey, R. M. VanHulet, M. E. El-Halawani and H. P. Van Krey. 1991. Protein and energy self-selection of turkey hens, serum prolactin and LH Concentrations. Comparative Biochemistry and Physiology A: Comparative Physiology 100:495-499. crossref(new window)

13.
Fortune, J. E., R. N. Eisler and S. E. Vincent. 1986. Prolactinsteroidogenesis by rat granulosa cells II effects on oestradiol. Biol. Reprod. 35:92-99. crossref(new window)

14.
Gitay-Goren, H., E. S. Lindenbaun and Z. Kraien. 1989. Prolactin inhibits hCG stimulated steroidogenesis and cAMP possibly by increasing phospodiesterase activity in rat granulose cells. Molecular and Cellular Endocrinology 61:69-76. crossref(new window)

15.
Guemene, D. and J. B. Williams. 1994. Relationships between broodiness expressions, laying persistency and concentration of hormones during the first productive period in turkey hens, Reprod. Nutr. Dev. 34:371-381. crossref(new window)

16.
Hall, P. E. and S. B. Sufi. 1981. Programme for the provision of matched assay reagents for the RIA of hormones in reproductive physiological method manual, Geneva, Switzerland.

17.
Henderson, K. M., A. S. Menilly and I. A. Swanton. 1982. Gonadotrophin and Steroid concentration in bovine follicle size. J. Reprod. Fertil. 65:465-473. crossref(new window)

18.
Hillier, S. G. 1981. Regulation of follicular estrogen biosynthesis a surway of current concepts Journal of Endocrinology. 89:3-18.

19.
Kaprowski, R. W. and A. Tucker. 1971. Radioimmunoassay of Prolactin. J. Dairy Sci. 54:1675-1680.

20.
Marrone, B. L., J. P. Wiebe, K. D. Backingham and F. Hertelendy. 1985. Analysis of steroid metabolites produced by theca cells from adult domestic hen. J. Steroid Biochem. 23:375-378. crossref(new window)

21.
MacNatty, K. P., R. S. Sawers and A. S. McNeilly. 1974. A possible role for Prolactin section by dopamine against antagonists. Endocrinology, 103:200-203. crossref(new window)

22.
McNeilly, A. S., G. Anna, J. Julie and P. W. Howie. 1982. Evidence for direct inhibition of ovarian function by prolactin. J. Reprod. Fertil. 65:559-569. crossref(new window)

23.
McNatty, K. P., P. Neal and T. G. Baker. 1976. Effect of prolactin on production of progesterone by mouse ovaries in vitro. J. Reprod. Fertil. 47:155-156. crossref(new window)

24.
Mc Neilly, A. S. and D. T. Baird. 1983. Direct effect of prolactin, induced by TRH injection on ovarian steroidal secretion in ewe. J. Reprod. Fertil. 69:559:568.

25.
Marsh, J. B., P. J. Sharp, P. W. Wilson and H. M. Sang. 1994. Effect of active immunization against recombinant-derived chicken prolactin fusion protein on the onset of broodiness and photo-induced egg laying in bantam hens. J. Reprod. Fertil. 101:227-223. crossref(new window)

26.
Nicholas, T. J., A. R. Goldsmith and A. Dawson. 1988. Photo refractoriness in birds in comparison with mammals. Physiological Reviews. 68:133-176.

27.
Niswender, G. D. 1974. Influence of 2-bromo-$\alpha$-ergocriptine on serum levels of prolactin and the estrous cycle in sheep. Endocrinology 94:612-615. crossref(new window)

28.
Porter, T. E., J. L. Silsby, B. M. Hagris, S. C. Fehrer and M. E. El Halawani. 1991. Ovarian steroid production in vitro during gonadal regression in the turkey. II changes induced by forced moulting. Bio. Reprod. 45:587-591. crossref(new window)

29.
Ranjhan, S. K. 1980 Animal Nutrition in Tropics. Vikas Publishing House Pvt. Ltd., NewDelhi. pp. 296-309.

30.
Reddy, I. J., C. G. David, P. V. Sarma and Khub Singh. 2001. Prolactin hormone and intersequence pause days in domestic chicken. Vet. Rec. 149 (in press)

31.
Robinson, F. E., R. T. Hardin and J. L. Robblee. 1990. Reproductive sequences in domestic Fowl. Effect on egg production, sequences length and inter sequence pause length. Br. Poult. Sci. 31:871-879. crossref(new window)

32.
Rozenboim, I., J. L. Tabibzadeh and M. E. ElHalawani. 1993. Effect of ovine prolactin administration on hypothalamic Vasoactive Intestinal Peptide (VIP), gonadotrophin releasing hormone I and II content and anterior pituitary VIP receptors in laying turkey hens. Bio. Reprod. 48:1246-1250. crossref(new window)

33.
Snedecor F. W. and W. G. Cochran. 1994. Statistical methods 8th edn., Iowa State University Press, Ames, Iowa.

34.
Sharp, P. J., R. J. Sterling, R. T. Talbout and N. S. Huskinson. 1989. The role of hypothalamic vasoactive intestinal polypeptide in the maintenance of prolactin secretion in incubating bantam hens. J. Endocrinology 122:5-13. crossref(new window)

35.
Sharp, P. J., A. Dawson and R. W. Lea. 1998. Control of Leutinizing hormone and prolactin secretion in birds. Comparative Biochemistry and Physiology part C. 119:275-282.

36.
Sharp, P. J. 1999. Regulation of avian prolactin secretion. In: Recent Developments in Comparative Endocrinology and Neurobiology, 19 CECE pp. 121-125.

37.
Veldhius, J. D., P. Klase and M. J. Hammond. 1981. Divergent effects of prolactin upon steriodogenesis by porcine granulose cells in vitro: influence of cytodifferentation. Endocrinology, 107:42-46. crossref(new window)

38.
Wang, C, A. J. W. Hsuch and G. F. Erickson. 1979. Induction of functional prolactin receptors by follicle stimulating hormone in rat granulosa cells in vivo and in vitro. J. Bio. Chem. 257:11330-11336.

39.
Wong, E. A., N. H. Ferrin, J. L. Silsby and M. E. El Halawani. 1991. Cloning of turkey prolactin cDNA: expression of prolactin mRNA throughout the reproductive cycle of the domestic turkey. General and Comparative Endocrinology. 83:18-26. crossref(new window)

40.
You, S., L. K. Foster, J. L. Silsby, M. E. El Halawani and D. N. Foster. 1995. Sequence analysis of the turkey LH beta subunit and its regulation by gonadotrophin releasing hormone and prolactin in cultured pituitary cells. J. Molecular Endocrinology 14:117-129. crossref(new window)

41.
Youngren, O. M., M. E. El Halawani, J. L. Silsby and R. E. Philips. 1993. Effect of reproductive condition on LH and PRL release induced by electrical stimulation of the turkey hypothalamus. General and comparative Endocrinology 83:220-228. crossref(new window)

42.
Youngren, O. M., Y. Chaischa and M. E. El Halawani. 1998. Serotogenic stimulation of avian prolactin secretion requires an intact dopaminergic system. General and Comparative Endocrinology 112:63-68. crossref(new window)

43.
Zadworny, D., J. L. Walton and R. J. Etches. 1985. Effect of feed and water or forced feeding on plasma prolactin concentration in turkey hens. Bio. Reprod. 32:241-24. crossref(new window)