Advanced SearchSearch Tips
Effects of Exogenous Bovine Somatotropin on Mammary Function of Late Lactating Crossbred Holstein Cows
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Exogenous Bovine Somatotropin on Mammary Function of Late Lactating Crossbred Holstein Cows
Tanwattana, P.; Chanpongsang, S.; Chaiyabutr, N.;
  PDF(new window)
The objective of the present study was to determine the effect of exogenous bovine somatotropin on the mammary function in late lactating crossbred Holstein cows. Twelve 87.5% late lactating Holstein cows, approximately 30 weeks postpartum, were divided into two groups of 6 animals each. Animals in the control group were given sodium bicarbonate buffer by subcutaneous injection, while animals in the treated group were given recombinant bovine somatotropin (bST) by subcutaneous injection with 500 mg of bST (14 day prolonged-release bST). After bST injection, milk yield significantly increased from the control level on day 8 to day 20 (p<0.05) with a concomitant increase in mammary blood flow (p<0.01). An increase in mammary blood flow in response to bST treatment was greater than an increase in milk production. An increased plasma concentration of IGF-I coincided with an increase in mammary blood flow in animals treated with bST. There were no significant changes in the concentration of arterial plasma glucose concentration, the arteriovenous concentration difference (A-V difference) and mammary extraction ratio while the mammary glucose uptake increased when compared to the control group. The concentration of arterial plasma triglyceride decreased throughout the experimental period in animals give bST. The plasma concentration of acetate, and the mammary uptake for acetate significantly increased (p<0.05) after bST treatment. The action of bST did not affect the plasma concentration, A-V difference and extraction ratio across the mammary gland for -hydroxybutyrate. The concentrations of milk fat and lactose tended to increase during bST treatment. Milk protein concentration initially increased in the first few days and decreased after bST injection when compared to the pretreated period. The present results indicated that bST could affect the mammary function in late lactating cows by increase in milk yield involving changes in both extra-mammary and intra-mammary mechanisms. The exogenous bST exerted its galactopoietic action through an increase in circulating IGF-I of the late lactating Crossbred Holstein cattle.
Bovine Somatotropin;Mammary Function;Late Lactation;Crossbred Holstein Cows;
 Cited by
Effects of Long Term Exogenous Bovine Somatotropin on Nutrients Uptake by the Mammary Gland of Crossbred Holstein Cattle in the Tropics,Chaiyabutr, Narongsak;Thammacharoen, S.;Komolvanich, S.;Chanpongsang, S.;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 9, pp.1407-1416 crossref(new window)
Bauman, D. E. and R. G. Vernon. 1993. Effects of exogenous bovine somatotropin on lactation. Annu. Rev. Nutr. 13:437-461. crossref(new window)

Chaiyabutr, N. 1994. The determination of fat concentration in milk by centrifugal method. Dairy cattle newsletter. 6(1):3-4.

Chaiyabutr, N., S. Komolvanich, S. Preuksagorn and S. Chanpongsang. 2000a. Plasma levels of hormones and metabolites as affected by the forages type in two different types of crossbred Holstein cattle. Asian-Aus. J. Anim. Sci. 13:1359-1366.

Chaiyabutr, N., S. Komolvanich, S. Preuksagorn and S. Chanpongsang. 2000b. Comparative studies on the utilization of glucose in the mammary gland of crossbred Holstein cattle feeding on different types of roughage during different stages of lactation. Asian-Aus. J. Anim. Sci. 13(3):334-347.

Collier, R. J., J. P. McNamara, C. R. Wallace and M. H. Dehoff. 1984. A review of endocrine regulation of metabolism during lactation. J. Anim. Sci. 59:498-510.

Davis, S. R., R. J. Collier, J. P. McNamara, H. H. Head and W. Sussman. 1988. Effects of thyroxin and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. J. Anim. Sci. 66:70-79.

Faulkner, A. 1999. Changes in plasma and milk concentrations of glucose and IGF-I in response to exogenous growth hormone in lactating goats. J. Dairy Res. 66:207-214. crossref(new window)

Fleet, I. R., F. M. Fullerton, R. B. Heap, T. B. Mepham, P. D. Gluckman and I. C. Hart. 1988. Cardiovascular and metabolic response during growth hormone treatment of lactation treatment. J. Dairy Res. 55:479-485. crossref(new window)

Fullerton, F. M. 1989. Cardiovascular responses and mammary substrate uptake in jersey cows treated with pituitary-derived growth hormone during late lactation. J. Dairy Res. 56(1):27-35. crossref(new window)

Glimm, D. R., V. E. Baracos and J. J. Kennelly. 1988. Effect of bovine somatotropin on the distribution of immunoreactive insulin-like growth factor-I in lactating bovine mammary tissue. J. Dairy Sci. 71:2923-2935.

Glimm, D. R., V. E. Baracos and J. J. Kennelly. 1990.Molecular evidence for the presence of growth hormone receptors in the bovine mammary gland. J. Endocrinol. 126:R5. crossref(new window)

Gluckman, P. D., B. H. Breier and S. R. Davis. 1987. Physiology of the somatotropic axis with particular reference to the ruminant. J. Dairy Sci. 70:442.

Granner, D. K. 1996. Hormones of the pancreas and gastrointestinal tract. In: Harper's biochemistry. 24th ed., J. Doland editor, USA. 581-598.

Kazmer, G. W., M. A. Barnes, R. M. Akers and W. D. Whittier. 1986. Lactogenic hormone receptors in mammary membrane preparations from prepartum and 60 and 180 day postpartum Holstein cattle. J. Endocrinol. 109:175. crossref(new window)

Linzell, J. L. and M. Peaker. 1971. Mechanism of milk secretion. Physiological Review 51:564-579.

McGuire, M. A., J. L. Vicini, D. E. Bauman and J. J. VeenHuizen. 1992. Insulin-like growth factors and binding proteins in ruminants and their nutritional regulation. J. Anim. Sci. 70: 2901-2910.

Miller, P. S., B. L. Reis, C. C. Calvert, E. J. Depeters and R. L. Baldwin. 1991. Patterns of nutrient uptake by the mammary glands of lactating dairy cows. J. Dairy Sci. 74:3791-3799.

Nielson, M. O. 1988. Effect of recombinantly derived bovine somatotropin on mammary gland synthetic capacity in lactating goats. J. Anim. Physiol .a. Anim. Nutr. 59:263-272. crossref(new window)

Peel, C. J. and D. E. Bauman. 1987. Somatotropin and lactation. J. Dairy Sci. 70:74-86.

Peel, C. J., J. F. Thomas, D. E. Baumann and R. C. Gorewit. 1983. Effects of exogenous growth hormone in early and late lactation on lactational performance of dairy cows. J. Dairy Sci. 66:776-782.

Prosser, C. G., I. R. Fleet, A. N. Corps, E. R. Froesch and R. B. Heap. 1990. Increase in milk secretion and mammary blood flow by intra-arterial infusion of insulin- like growth factor-I into the mammary gland of the goat. J. Endocrinol. 126:437-443. crossref(new window)

Prosser, C .G., I. R. Fleet, A. J. Davis and R. B. Heap. 1991b. Mechanism of secretion of plasma insulin-like growth factor-I into milk of lactating goats. J. Endocrinol. 131:459-466. crossref(new window)

Prosser, C. G., C. Royle, I. R. Fleet and T. B. Mepham. 1991a. The galactopoietic effect of bovine growth hormone in goats is associated with increased concentrations of insulin-like growth factor-I in milk and mammary tissue. J. Endocrinol. 128:457-463. crossref(new window)

Sharma, B. K., M. J. Vandehaar and N. K. Ames. 1994. Expression of insulin-like growth factor-I in cows at different stages of lactation and in late lactation cows treated with somatotropin. J. Dairy Sci. 77:2232-2241.

Tele, F. F., K. Young and J. W. Stull. 1978. A method for rapid determination of lactose. J. Dairy Sci. 61:506-508.

Walker, N. I., R. E. Bennett and J. F. R. Kerr. 1989. Cell death by apoptosis during involution of the lactating breast in mice and rats. Am. J. Anatomy. 185:19-32. crossref(new window)

Zhao, F. Q., W. M. Moseley, H. A. Tucker and J. J. Kennelly. 1996. Regulation of glucose transporter gene expression in mammary gland, muscle and fat of lactating cows by administration of bovine growth hormone and bovine growth hormone-releasing factor. J. Anim. Sci. 74:183-189.