JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Excessive Dietary Conjugated Linoleic Acid Affects Hepatic Lipid Content and Muscular Fatty Acid Composition in Young Chicks
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Excessive Dietary Conjugated Linoleic Acid Affects Hepatic Lipid Content and Muscular Fatty Acid Composition in Young Chicks
An, B.K.; Shinn, K.H.; Kobayashi, Y.; Tanaka, K.; Kang, C.W.;
  PDF(new window)
 Abstract
The effects of dietary conjugated linoleic acid (CLA) on lipid concentrations and fatty acid composition of various tissues were studied in young chicks. From 7 days of age, a total of 160 chicks were divided into 4 groups, placed into 4 pens per group (10 birds per pen) and fed one of four experimental diets containing 6% tallow (TO 6%), 4% tallow plus 2% CLA (TO 4%-CLA 2%), 2% tallow plus 4% CLA (TO 2%-CLA 4%) or 6% CLA (CLA 6%) for 3 weeks. There were no significant differences in growth performances and the relative weights of various organs, but relative liver weight of chicks fed dietary CLA at 4 and 6% levels was significantly higher (p<0.05) than that of TO 6% group. The chemical compositions of leg muscle were not affected by CLA feeding. However, hepatic total lipid of chicks fed 6% CLA diet was significantly higher (p<0.05) than those of TO 6% and TO 4%-CLA 2% groups. The concentrations of various lipid fractions in serum were not affected by CLA feeding. With the increase in dietary CLA levels, cis 9-trans 11 CLA, trans 10-cis 12 CLA and total CLA of leg muscle increased linearly. The relative proportions of C18:1 -9 and C20:4 -6 fatty acids in the leg muscles of chicks fed the CLA containing diets were significantly lower (p<0.05) than those of TO 6% group. These results indicate that the levels of CLA isomers were increased linearly in dose-dependent manner after feeding of synthetic CLA source. But it was also observed that excessive amount of dietary CLA resulted in the possible adversely effects, such as increase of liver weight, hepatic lipid accumulation and serum GOT level.
 Keywords
Conjugated Linoleic Acid;Hepatic Total Lipid;Concentration of Serum Lipids;Tissue Fatty Acid Composition;Young Chicks;
 Language
English
 Cited by
1.
Nutritional Values of Red Pepper Seed Oil Meal and Effects of Its Supplementation on Performances and Physiological Responses of Broiler Chicks,;;;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 6, pp.971-975 crossref(new window)
2.
발아, 발효 처리한 비상품성대두 급여가 산란계의 생산성과 계란의 품질에 미치는 영할,신진호;박정민;박다정;전우민;송재철;김성기;안병기;강창원;정우석;김진만;

한국축산식품학회지, 2008. vol.28. 5, pp.667-674 crossref(new window)
3.
Conjugated Linoleic Acid as a Key Regulator of Performance, Lipid Metabolism, Development, Stress and Immune Functions, and Gene Expression in Chickens,;

Asian-Australasian Journal of Animal Sciences, 2009. vol.22. 3, pp.448-458 crossref(new window)
4.
Effect of Conjugated Linoleic Acid Feeding on the Growth Performance and Meat Fatty Acid Profiles in Broiler: Meta-analysis,;;;;;;;;;;

Asian-Australasian Journal of Animal Sciences, 2013. vol.26. 7, pp.995-1002 crossref(new window)
5.
Comparison of Growth Performance, Carcass Characteristics and Meat Quality of Korean Local Chickens and Silky Fowl,;;;;;;;;

Asian-Australasian Journal of Animal Sciences, 2014. vol.27. 3, pp.398-405 crossref(new window)
 References
1.
Ahn, D. U., J. L. Sell, C. Jo, M. Chamruspollert and M. Jeffrey. 1999. Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. Poult. Sci. 78:922-928.

2.
An B. K., S. Ohtani and K. Tanaka. 1995. Effects of dietary vitamin B6 levels on lipid concentration and fatty acid composition in growing chicks. Asian-Aust. J. Anim. Sci. 8:627-633.

3.
AOAC. 1990. Official Methods of Analysis of the Association of Official Analytical Chemists, 15th. Ed.

4.
Aydin, R., M. W. Pariza and M. E. Cook. 2001. Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. J. Nutr. 131:800-806.

5.
Bauman, D. E., D. M. Barbano, D. A. Dwyer and J. M. Griinari. 2000. Technical note: production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. J. Dairy Sci. 83:2242-2245.

6.
Belury, M. A. and A. Kempa-Steczko. 1997. Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32:199-204. crossref(new window)

7.
Benito, P., G. J. Nelson, D. S. Kelley, G. Bartolini, P. C. Schmidt and V. Simon. 2001. The effect of conjugated linoleic acid on plsma lipoproteins and tissue fatty acid composition in humans. Lipids 36:229-236. crossref(new window)

8.
Chamruspollert, M. and J. L. Sell. 1999. Transfer of dietary conjugated linoleic acid to egg yolks of chickens. Poult. Sci. 78:1138-1150.

9.
Cook, M. E., C. C. Miller, Y. Park and M. Pariza. 1993. Immune modulation by altered nutrient metabolism: Nutritional control of immune-induced growth depression. Poult. Sci. 72:1301-1305.

10.
Du, M. and D. U. Ahn. 2002. Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. Poult. Sci. 81:428-433.

11.
Dugan, M. E. R., J. L. Aalhus, A. L. Schaefer and J. K. G. Kramer. 1997. The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can J. Anim. Sci. 77:723-725.

12.
Duncan, D. B. 1955. Multiple range and multiple F test. Biometr 11:1-42. crossref(new window)

13.
Folch, J., M. Lee and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem. 226:497-509.

14.
Ip C., S. Banni, E. Angioni, G. Carta, J. McGinley, H. J. Thompson, D. Barbano and D. Bauman. 1999. Conjugated linoleic acidenriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. J. Nutr. 129:2135-2142.

15.
Jones, S., D. W. Ma, F. E. Robinson, C. J. Field and M. T. Clandinin. 2000. Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens. J. Nutr. 130:2002-2005.

16.
Lee, K. N., D. Kitchevsky and M. W. Pariza. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108:19-25. crossref(new window)

17.
Lee, K. N., M. W., Pariza and J. M. Ntambi. 1998. Conjugated linoleic acid decreases hepatic stearyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Com. 248:817-821. crossref(new window)

18.
Lumeij, J. T. 1997. Avian Clinical Biochemistry. In: Clinical Biochemistry of Domestic Animals (Ed. J. J. Kaneko, J. W. Harvey and M. L. Bruss. 5th) Academic Press. pp. 857-883.

19.
National Research Council. 1994. Nutrients Requirements of Poultry. 9th rev. ed. National Academic Press, Washington, DC.

20.
Nicolosi, R. J., E. J. Rogers, D. Kritchevsky, J. A. Scimeca and P. J. Huth. 1997. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22:266-277.

21.
Park, Y., K. J. Albright, W. Lui, J. M. Storkson, M. E. Cook and M. W. Pariza. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids 32:853-858. crossref(new window)

22.
SAS. 1986. SAS User's guide. Statistical Analysis System Institute. Inc., Cary, NC.

23.
Takenoyama, S., S. Kawahara, H. Murata and K. Yamauchi. 1999. Investigation of some preparation procedures of fatty acid methyl esters for capillary gas-liquid chromatographic analysis of conjugated linoleic acid in meat. Anim. Sci. J. 70:336-342.

24.
Yamasaki, M., A Ikeda, A. Hirao, Y. Tanaka, Y. Miyazaki, M. Shimada, K. Sugimachi, H. Tachibana and K. Yamada. 2001. Effect of dietary conjugated linoleic acid on the in vivo growth of rat hematoma dRLh-84. Nutr. Cancer 40:140-148. crossref(new window)

25.
Yamasaki, M., K. Kishihara, K. Mansho, Y. Ogino, M. Kasai, M. Sugano, H. Tachibana and K. Yamada. 2000. Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. Biosci. Biotechnol. Biochem. 64:2159-2164. crossref(new window)