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Detection of Polymorphism of Growth Hormone Gene for the Analysis of Relationship between Allele Type and Growth Traits in Karan Fries Cattle
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 Title & Authors
Detection of Polymorphism of Growth Hormone Gene for the Analysis of Relationship between Allele Type and Growth Traits in Karan Fries Cattle
Pal, Aruna; Chakravarty, A.K.; Bhattacharya, T.K.; Joshi, B.K.; Sharma, Arjava;
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The present study was conducted to detect polymorphism at growth hormone gene in Karan Fries bulls. A 428 bp fragment of growth hormone gene spanning over exon, intron and exon was amplified and digested with AluI restriction enzyme to identify polymorphism at this locus. Karan Fries bulls were found to be polymorphic at this locus. Two genotypes LL and LV were identified in Karan Fries with higher allelic frequency for L allele. In Karan Fries males, the average birth weight, 3 months body weight and daily body weight gains of LL homozygotes were significantly higher than that of LV heterozygotes. Genetic distances of KF bulls with respect to genotype along with 3 months body weight and average daily body weight gain forms a single cluster of bulls with LL genotype, while individuals with LV genotype forms three distinct clusters indicating more influence of L allele on growth traits.
Association;Birth Weight;Cattle;Body Weight;Growth Hormone Gene;Polymorphism;
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Badola, S., T. K. Bhattacharya, T. K. Biswas, P. Kumar and A. Sharma. 2003. Association of beta-lactoglobulin polymorphism with milk production traits in cattle. Asian-Aust. J. Anim. Sci. 16(11):1560-1564.

Bassam, B. J., G. Gaetano-Anolles and P. M. Gresshoff. 1991. Fast and sensitive silver staining of DNA in polyacrylamide gels. Analytical Biochem. 196:80-83.

Biswas, T. K., T. K. Bhattacharya, A. D. Narayan, S. Badola, P. Kumar and A. Sharma. 2003. Growth hormone gene polymorphism and its effect on birth weight in cattle and buffalo. Asian-Aust. J. Anim. Sci. 16(4):494-497.

Boyd, R. D. and D. E. Baumann. 1989. Mechanism of action of somatotropin in growth. In: Current Concepts of Animal Growth Regulation (Ed. D. R. Campion, G. J. Haeesman, R. J. Martin). Plenum Press, New York, pp. 257-293.

Falconer, D. S. and T. F. C. MacKay. 1996. Introduction to quantitative genetics, 4th Edn. Longman Group Ltd., Essex. England.

Gluckman, P. D., B. H. Breier and S. R. Davis. 1987. Physiology of the omatotropic axis with particular reference to the ruminant. J. Dairy Sci. 70:442-466.

Gordon, D. F., D. Quick, C. R. Erwin, J. Donelson and R. A. Maurer. 1983. Nucleotide sequence of the bovine growth hormone chromosomal gene. Mol. Cell. Endocrinol. 33:81-95.

Hart, I. C. and I. D. Johnson. 1986. Manipulation of milk yield with growth hormone. In: Recent Advances in Animal Nutrition (Ed. W. Haresign and D. J. A. Cole). Butterworths, London, UK.

Hediger, R., S. E. Johnson, W. Barendse, R. E. Drinkwater, S. S. Moore and J. Hetzel. 1990. Assignment of the GH gene locus to 19q26qter in cattle and to 11q25qter in sheep by in situ hybridization. Genomics 8:171-174.

Lechniak, D., G. Machnik, M. Szydlowski and M. Switonski. 1999. Growth hormone gene polymorphism and reproductive performance of AI bulls. Theriogenology 52:1145-1152.

Jobson, J. D. 1992. Applied multivariate data analysis, Vol.2. Published by Springer-Verlag, New York Inc.

Lucy, M. C., S. D. Hauser, P. J. Eppard, G. G. Krivi, J. H. Clark, D. E. Bauman and R. J. Collier. 1993. Variants of somatotropin in cattle : Gene frequencies in major dairy breeds and associated milk production. Domestic Anim. Endocrinol. 10:325-333.

Neathery. M. W., C. T. Crowe, G. F. Hartnell, J. J. Veensuizen, J. O. Reagan and D. M. Blackmon. 1991. Effects of sometribove on performance, carcass composition and chemical blood characteristics of dairy calves. J. Dairy Sci. 74:3933-3939.

Sambrook, J., E. F. Fritsch and T. Maniatis. 1989. Molecular cloning - A Laboratory Manual. 2nd Edn., Vol.3, Cold Spring Harbour Laboratory Press, pp. 6:3-4.

Zwierzchowski, L., J. Oprzadek, E. Dymnicki and P. Dzierzbicki. 2001. An association of growth hormone, kappa-casein, betalactoglobulin, leptin and pit-1 loci polymorphism with growth rate and carcass traits in beef cattle. Anim. Sci. Papers and Reports 19:65-77.