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Effects of Florfenicol and Chromium (III) on Humoral Immune Response in Chicks
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 Title & Authors
Effects of Florfenicol and Chromium (III) on Humoral Immune Response in Chicks
Cao, Jiyue; Li, Kui; Lu, Xiaocong; Zhao, Yaxin;
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One hundred and sixty day-old Hainan chicks were randomly allotted into eight pens to investigate the effect of different dietary concentrations of chromium (Cr) in the form of chromium chloride, and different dosages of florfenicol on humoral immune responses by determining antibody titers to Newcastle disease (ND) vaccines using the hemagglutination inhibition test. The results indicated that ND antibody titers were significantly higher in chicks receiving Cr at low (5 mg/kg feed) and middle (10 mg/kg feed) dose compared with the control (p<0.01). However, ND antibody titers were significantly decreased in chicks receiving Cr at a high dosage of 500 mg/kg feed (p<0.01), though the ND antibody titers of the early days (d 21 and d 28 of age) were higher than that of the control group. It is suggested that excessive Cr intake has detrimental effects on ND antibody production in chicks. No significantly lower response was measured in chicks that received florfenicol at a low dosage of 50 mg/kg feed (p>0.05), but the ND antibody titers were significantly decreased in chicks receiving 200 and 400 mg/kg feed of the drug (p<0.01). The ND antibody titers of group receiving 200 mg/kg feed of florfenicol plus 10 mg/kg Cr were slightly higher than that of the group receiving single florfenicol of 200 mg/kg although, no significant differences were observed between these two treatments. It is suggested that the humoral immune response impaired by florfenicol (200 mg/kg feed) could not be significantly reversed by Cr (10 mg/kg feed).
Chromium;Florfenicol;Hainan Chicks;Humoral Immune Response;Newcastle Disease Virus Antibody Titers;
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Anderson, R. A. 1978. Chromium. In: Traces element in human and animals nutrition, 5th Ed.Vol. 1 (Ed. W. Mertz). Academic press. Inc. New York. p. 255.

Asmatullah, A. Asma, A. Latif and A. R. Shakoori. 1999. Effect of hexavalent chromium on egg laying capacity, hatchability of eggs, thickness of egg shell and post-hatching development of Gallus domesticus. Asian-Aust. J. Anim. Sci. 12:944-950.

Bretzlaff, K. N., C. A. Neff-Damis and R. S. Ott. 1987. Florfenicol in non-lactating dairy cows: Pharmacokinetics binding to plasma protein and effects on phagocytosis by blood neutrophils. J. Vet. Pharmacol. Therap. 10:233-240.

Burton, T. L. 1995. Supplemental chromium: its benefits to the bovine immune system. Anim. Feed Sci. Technol. 53:117.

El-Banna, H. A. 1998. Pharmacokinetics of florfenicol in normal and Pasteurella-infected Muscovy ducks. Br. Poult. Sci. 39:492-496. crossref(new window)

Friedman, A., I. Bartov and D. Sklan. 1998. Humoral immune response impairment following excess vitamin E nutrition in chick and turkey. Poult. Sci. 77:956- 962.

Hu, D. F., J. Z. Shen and X. A. Wu. 2002. The pharmacokinetics of florfenicol in broiler chickens. Chin. J. Anim. Vet. Sci. 33:384-388.

Heugten, E. V. and J. W. Spears. 1997. Immune response and growth of stressed weanling pigs fed diets supplemented with organic or inorganic forms of chromium. J. Anim. Sci. 75:409-416.

Kegley, E. B., J. W. Spears and T. T. Brown. 1996. Immune response and disease resistance of calves fed chromium nicotinic acid complex or chromium chloride. J. Dairy Sci. 79:1278-1283.

Kumari, B. S. and R. K. Chandra. 1993. Overnutrition and immune response. Nutr. Res. 13 (suppl.1): S3-S18.

Luo, X. G., S. F. Li, B. Liu and G. Z. Shao. 2002. Effects of dietary chromium on egg production performance, egg quality, serum biochemical traits and immune responses of heat stressed layers. Chin. J. Anim. Vet. Sci. 33:313-320.

Lundena, T. L., S. Miettinenb and L.G. Lonnstroma. 1999. Effects of florfenicol on the immune response of rainbow trout. Vet. Immunol. Immunopathol. 67:317-325.

Mooney, K. W. and G. L.Cromwell. 1997. Efficacy of chromium picolinate and chromium chloride as potential carcass modifiers in Swine. J. Anim. Sci. 75:2661-2672.

Mowat, D. N. 1993. Chelated chromium for stressed feeder calves. Can. J. Anim. Sci. 73:49-55.

Neu, H. C. and K. P. Fu. 1980. In vitro activity of chloramphenicol and thiamphenicol analogs. Antimicrobial Agents and Chemotherapy. 18:311-316.

Page, M. J. 1990. Effects of florfenicol, chloramphenicol and thiamphenicol on phagocytosis, chemiluminessence and morphology of bovine polymorph onuclear neutrophil leuocytes. J. Dairy Sci. 73:1734-1744.

Page, T. G. and L. L. Southern. 1992. Effect of chromium picolinate on growth and serum and carcass traits of growing finishing pigs. J. Anim. Sci. 71:656.

Skolimowski, I. M., R. C. Knight and D. I. Edwards. 1983. Molecular basis of chloramphenicol and thiamphenicol toxicity of DNA in vitro. Journal of Antimicrobial Chemotherapy 12:535-542.

Syriopoulou, V. P., A. L. Harding, D. A. Goldmann and A. L. Smith. 1981. In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Antimicrobial Agents and Chemotherapy 19:294-297.

Sieroslawska, A., M. Studnicka and A. K. Siwicki. 1998. Antibiotics and cell-mediated immunity in fish-in vitro study. Acta. Vet. Brno. 67:329-334.

Varma, K. J., P. E. Adams, T. E. Powers, J. D. Powers and J. F. Lamendola. 1986. Pharmacokinetics of florfenicol in veal calves. J. Vet. Pharmacol. Therap. 9:412-425.

Yunis, A. A. 1981. Chloramphenicol toxicity and the role of the p-$NO_2$ in aplastic anemia. In: safety problems related to chloramphenicol and thiamphenicol therapy. (Ed. Najean, et al.). Raven. Press. New York. pp. 17-30.

Yunis, A. A., D. R. Manyan and G. K. Arimura. 1973. Comparative effects of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells. J. Labor. Clin. Med. 81:713-718.