Advanced SearchSearch Tips
Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs
Han, X.Y.; Xu, Z.R.; Wang, Y.Z.; Tao , X.; Li, W.F.;
  PDF(new window)
This experiment was conducted to investigate the effect of cadmium levels on weight gain, nutrient digestibility and the retention of iron, copper and zinc in tissues of growing pigs. A total of one hundred and ninety-two crossbred pigs (barrows, DurocLandraceYorkshine, 27.671.33 kg of average initial body weight) were randomly allotted to four treatments. Each treatment had three replicates with 16 pigs per pen. The corn-soybean basal diets were supplemented with 0, 0.5, 5.0, 10.0 mg/kg cadmium respectively, and the feeding experiment lasted for eight-three days. Cadmium chloride was used as cadmium source. The results showed that pigs fed the diet containing 10.0 mg/kg cadmium had lower ADG and FCR than any other treatments (p<0.05). Apparent digestibility of protein in 10.0 mg/kg cadmium-treated group was lower than that of other groups (p<0.05). There was lower iron retention in some tissues of 5.0 mg/kg and 10.0 mg/kg cadmium treatments (p<0.05). However, pigs fed the diet 10.0 mg/kg cadmium had higher copper content in most tissues than that of any other groups (p<0.05). There was a significantly increase of zinc retention in kidney of 10.0 mg/kg cadmium additional group (p<0.05) and zinc concentrations in lymphaden, pancreas and heart of 10.0 mg/kg cadmium treatment were lower than those of the control (p<0.05). This study indicated that relatively high cadmium level (10.0 mg/kg) could decrease pig growth performance and change the retention of iron, copper and zinc in most tissues during extended cadmium exposure period.
Growing Pigs;Cadmium;Growth Performance;Nutrient Digestibility;Iron;Copper;Zinc;
 Cited by
Effect of Cadmium in Feed on Organs and Meat Colour of Growing Pigs, Veterinary Research Communications, 2007, 31, 5, 621  crossref(new windwow)
Ammerman, C. B., S. M. Miller, K. R. Fick and S. L. Hansard II. 1977. Contaminating elements in mineral supplements and 1977their potential toxicity: A review. J. Anim. Sci. 44:485-508.

Anke, M., T. Masaoka, B. Groppel, G. Zervas and W. Arnhold. 1989. The influence off sulpher, molybdenum and cadmium exposure on the growth of goat, cattle and pig. Archiv. Fur. Tierernahrung 39:221-228.

AOAC. 1990. Official Methods of Analysis (15th Ed.). Assocition f Official Analytical Chemists. Washington, DC.

Bafundo, K. W., D. H. Baker and P. R. Fitzgerald. 1984. Eimeria acervulina infection and the zinc-cadmium interrelationship in the chick. Poult. Sci. 63:1828-1832.

Banis, R. J., W. G. Pond, E. F. Walker and J. R. O’Connor. 1969. Dietary cadmium, iron, and zinc interactions in the growing rat, Proc. Soc. Exp. Biol. Med. 130:802-806.

Brzoska, M. M. and J. Moniuszko-Jakoniuk. 2001. Interactions between cadmium and zinc in the organs. Food. Chem. Toxicol. 39:967-980.

Brzoska, M. M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk and J. Rogalska. 2000. Effect of short-term ethanol administration on cadmium retention and bioelement metabolism in rats continuously exposed to cadmium. Alcohol and Alcoholism. 5:439-445.

Chmielnicka, J. and B. Sowa. 1996. Cadmium interaction with essential metals (Zn, Cu, Fe), metabolism, metallothionein, and ceruloplasmin in pregnant rats and fetuses. Ecotoxicol. Environ. Safety 35:277-281.

Coppen-Jaeger, D. E. and M. Wilhelm. 1989. The effects of cadmium on zinc absorption in isolated rat intestinal preparations. Biol. Trace Elem. Res. 21:207-212.

Cotzias, G. C., D. C. Borg and B. Selleck. 1961. Virtual absence of turnover in cadmium metabolism: Cd109 studies in the mouse. Am. J. Physiol.. 201:927–930.

Cousins, R. J., A. K. Baber and J. R. Trout. 1973. Cadmium toxicity in growing swine. J. Nutr. 103:964-972.

Crowe, A. and E. H. Morgan. 1997. Effect of dietary cadmium on iron metabolism in growing rats. Toxicol. Appl. Pharmacol. 145:136-146.

Czarnecki, G. L. and D. H. Baker. 1982. Tolerance of the chick to excess dietary cadmium as influenced by dietary cysteine and by experimental infection with Eimeria acervulina. J. Anim. Sci. 54:983-988.

Davies, N. and J. Campbell. 1977. The effect of cadmium on intestinal copper absorption and binding in the rat. Life Sci. 20:955-960.

Elinder, C. G., M. Nordberg, B. Palm, L. Bjork and L. Jonsson. 1987. Cadmium, zinc, and copper in rabbit kidney metallothionein-relation to kidney toxicity. Environ. Res. 42:553-562.

Elsenhans, B., K. Kolb, K. Schumann and W. Forth. 1994. The longitudinal distribution of cadmium, zinc, copper, iron and metallothionein in the small intestinal mucosa of rats after administration of cadmium chloride. Biol. Trace Elem. Res.41:31-46.

Eybl, V., D. Kotyzova, J. Koutensky, V. Mickova, M. M. Jones and P. K. Singh. 1998. Effect of cadmium chelating agents on organ cadmium and trace element levels in mice. Analyst. 123:25-26.

Foulkes, E. C. 1985. Interactions between metals in rat jejunum:implications on the nature of cadmium uptake. Toxicol. 37:117-125.

Fox, M. R. S. 1987. Assessment of cadmium, lead and vanadium status of large animals as related to the human food chain. J. Anim. Sci. 65:1744-1752.

Fox, M. R. S., R. M. Jacob, A. O. L. Jones, B. E. Fry and C. L. Stone. 1980. Effects of vitamin C and iron on cadmium metabolism. Annals of the New York Academy of Sciences 355:249-261.

Hamilton, D. and L. Valberg. 1974. Relationship between cadmium and iron absorption. Am. J. Physiol. 227:1033-1037.

Hansen, L. G. and T. D. Hinesly. 1979. Cadmium from soil amended with sewage sludge: effects and residues in swine. Environ. Health. Persp. 28:51-57.

Jacobson, K. B. and J. E. Turner. 1980. The interaction of cadmium and certain other metal ions with proteins and nucleic acids. Toxicol. 16:1-37.

Jones, M. M. and M. G. Cherian. 1990. The search for chelate antagonists for chtonic cadmium intoxication. Toxicol. 62:1-25.

Joshi, J. G. and A. Zimmerman. 1988. Ferritin: an expanded role in metabolic regulation. Toxicol. 48:21-29.

Kanwar, K. C., S. C. Kaushal and R. V. Mehra. 1980. Clearance of orally administered 115mCd from rat tissues. Experientia. 15:1004-1005.

Koizumi, T., T. Yokota and K. Suzuki. 1994. Mechanism of cadmium-induced cytotoxicity in rat hepatocytes. Biol. Trace Elem. Res. 42:31-41.

Kozlowska, K., A. Brzozowska, J. Sulkoeska and W. Roszkowski. 1993. The effect of cadmium on iron metabolism in rats. Nutr. Res. 13:1163-1172.

Lisk, D. J., R. D. Boyd, J. N. Telford, J. G. Babish, G. S. Stoesand, C. A. Bache and W. H. Gutenmann. 1982. Toxicologic studies with swine fed corn grown on municipal sewage sludgeamended soil. J. Anim. Sci. 55:613-619.

Matsubara-Khan, J. and K. Machida. 1975. Cadmium accumulation in the mouse organs during sequential injections of cadmium109. Environ. Res. 10:29-38.

Miccadei, S. and A. Floridi. 1993. Sites of inhibition of mitochondrial electron transport by cadmium. Chem. Biol. Interact. 89:159-167.

Miller, W. J. 1971. Cadmium nutrition and metabolism in ruminants: Relationship to concentrations in tissues and products. Feedstuffs. July 17:24.

Mohan, J., R. P. Moudgal and J. N. Panda. 1992. Effects of cadmium salt on phosphomonoesterases activity and fertilizing ability of fowl spermatozoa. Indian J. Exp. Biol. 30:241-243.

Nasreddin, L. and D. Parent-Massin. 2002. Food contamination by metals and pesticides in the European Union. Should we worry? Toxicol. Lett. 127:29-41.

NRC. 1998. Nutrient Requirements of Swine (10th Ed.) National Academy Press. Washington, DC.

Oishi, S., J.-I. Nakagawa and M. Ando. 2000. Effects of cadmium administration on the endogenous metal balance in rats. Biol. Trace Elem. Res. 76:257-278.

Pond, W. G., P. Chapman and E. Jr. Walker. 1966. Influence of dietary zinc, corn oil and cadmium on certain blood components, weight gain and parakeratosis in young pigs. J. Anim. Sci. 25:122-127.

Pond, W. G. and E. F. Walker.. 1973. Cadmium-induced anemia in growing pigs: protective effect of oral and parenteral iron. J. Anim. Sci. 6:1122-1128.

Rambeck, W. A., H. W. Brehm and W. E. Kollmer. 1991. The effect of increased copper supplements in feed on the development of cadmium residues in swine. Zeitschrift fur Ernahrungswissenschaft. 30:298-306.

Rothe, S., J. Gropp, H. Weiser and W. A. Rambeck. 1994. The effect of vitamin C and zinc on the copper-induced increased of cadmium residues in swine. Zeitschrift fur Ernahrungswissenschaft. 33:61-67.

Raszy, J., H. Docekalova, J. Rubes, V. Gajduskova, J. Masek, L. Rodak and J. Bartos. 1992. Ecotoxicologic relations on a large pig-fattening farm located in a lignite mining area and near and solid-fuel electrical power plant. Vet. Med. 37:435-448.

Schafer, S. G. and W. Forth. 1984. Effect of acute and subchronic exposure to cadmium on the retention of iron in rats. J. Nutr. 114:1989-1996.

Sharma, G., R. Sandhir, R. Nath and K. Gill. 1991. Effect of ethanol on cadmium uptake and metabolism of zinc and copper in rats exposed to cadmium. J. Nutr. 121:87-91.

Sowa, B. and E. Steibert. 1985. Effect of oral cadmium administration to female rats during pregnancy on zinc, copper and iron content in placenta, foetal liver, kidney, intestine and brain. Arch. Toxicol. 56:256-263.

Steibert, E., B. Krol, K. Gralewska, M. Kaminki, O. Kaminska and E. Kusz. 1984. Cadmium-induced changes in the histoenzymatic activity in liver, kidney and duodenum of pregnant rats. Toxicol. Lett. 20:127-132.

Wang, S. C. 1994. Food Hygiene Testing and Technology Handbook. Chemical Industry Press, Beijin, China, pp. 185-189.

Webster, W. S. 1979. Iron deficiency and its role in cadmiuminduced fetal growth retardation. J. Nutr. 109:1640-1645.