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Bootstrap Analysis and Major DNA Markers of BM4311 Microsatellite Locus in Hanwoo Chromosome 6
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 Title & Authors
Bootstrap Analysis and Major DNA Markers of BM4311 Microsatellite Locus in Hanwoo Chromosome 6
Yeo, Jung-Sou; Kim, Jae-Woo; Shin, Hyo-Sub; Lee, Jea-Young;
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LOD scores related to marbling scores and permutation test have been applied for the purpose detecting quantitative trait loci (QTL) and we selected a considerable major locus BM4311. K-means clustering, for the major DNA marker mining of BM4311 microsatellite loci in Hanwoo chromosome 6, has been tried and five traits are divided by three cluster groups. Then, the three cluster groups are classified according to six DNA markers. Finally, bootstrap test method to calculate confidence intervals, using resampling method, has been adapted in order to find major DNA markers. It could be concluded that the major markers of BM4311 locus in Hanwoo chromosome 6 were DNA marker 100 and 95 bp.
Bootstrap Analysis;LOD Score;QTL;Permutation Test;K-means Clustering;
 Cited by
Microsatellite 의 대립유전자 빈도를 이용한 한우의 경제형질과의 연관성 규명,오재돈;공홍식;조병욱;이미랑;전광주;이학교;

생명과학회지, 2008. vol.18. 9, pp.1225-1229 crossref(new window)
Bishop, M. D., S. M. Kappes, J. W. Keele, R. T. Stone, S. L. F. Sunden, G. A. Hawkins, S. S. Toddo, R. Fries, M. D. Grosz, J. Yoo and C. W. Beattier. 1994. A genetic linkage map for cattle. Genetics 136:619-639.

Casas, E., S. D. Shackelford, J. W. Keele, R. T. Stone, S. M. Kappes and M. Koohmaraie. 1999a. Evidence of quantitative trait loci affecting growth and carcass composition traits in cattle segregating the muscle hypertrophy locus. J. Anim. Sci. 77 Supplement(1):126-127.

Casas, E., J. W. Keele, S. M. Kappes and R. T. Stone. 1999b. A quantitative trait locus for birth and yearling weight segregates on chromosome 6 in Bos Taurus cattle. Plant & Animal Genome Ⅶ Conference, San Diego, CA: p. 150.

Chotai, J. 1984. On the lod score method in linkage analysis. Ann. Hum. Genet. 48:359-378.

Churchill, G. A. and R. W. Doerge. 1994. Empirical Threshold Values for Quantitative Trait Mapping, Genetics 138:963-971.

Efron, B. and R. Tibshirani. 1993. 'An Introdction to bootstrap' CHAMPMAN & HALL

Georges, M., D. Nielsen, M. Mackinnon, A. Mishra, R. Okimoto, A. T. Pasquino, L. S. Sargeant, A. Sorenson, M. R. Steele, X. Zhao, J. E. Womack and I. Hoeschele. 1995. Mapping quantitative trait loci controlling milk production in dairy cattle by exploting progeny testing. Genetics 139:907-920.

Good, P. 1994. Permutation Test: A peactical Guide to resampling for testing Hypothesis, Spring-Verlag, New York.

Hirano, T., N. Kobayashi, T. Nakamaru, K. Hara and Y. Sugimoto. 1998. Linkage analysis of meat quality in Wagyu. 26th International Conference on Animal Genetics, Auckland, New Zealand:E019.

Kim, J. W., S. I. Park and J. S. Yeo. 2003. Linkage Mapping and QTL on Chromosome 6 in Hanwoo (Korean Cattle). Asian-Aust. J. Anim. Sci. 16(10):1402-1405.

Kim, J. W., T. K. Jang, Y. A. Park and J. S. Yeo. 2000. Linkage mapping of chromosome 6 in the Korean Cattle (Hanwoo). Asian-Aust. Anim. Sci.13 (Suppl.):235.

Kim, M. J., J. Y. Lee, J. S. Yeo, Y. W. Lee and Y. J. Joe. 2003. A major DNA mining of BM4311 in Hanwoo. Proceedings of the Spring Conference, Cheju National Univ. 305-311.

Knott, S. A. and C. S. Haley. 1992. Aspects of maximum likelihood method methods for the mapping of quantitative trait loci in line crosses. Genet. Res. 60:139-151.

Lander, E. and D. Bostein. 1989. Mapping mendelian factors underlying quantative traits using RFLP linkage maps. Genetics 121:185-199.

McPherron, A. C. and S. J. Lee. 1997. Double muscling in cattle due to mutations in the myostatin gene. Proc. Netl. Acad. Sci. USA 23:12457-12461.

Ott, Jurg. 1999. Analysis of human genetic linkage, 3rd ed. The Johns Hopkins university press.

Mannen, H. S., F. Tsuji, F. Mukai, N. Goto and S. Ohtagaki. 1993. Genetic Similarity using DNA fingerprinting in cattle to determine relationship coefficient. J. Hered. 84:166-169.

Peter, M. Visscher, Robin Thompson and Chris S. Haley. 1996. Confidence Intervals in QTL Mapping by Bootstrapping. Genetics 143:1013-1020.

Phillip, G. 1994. 'Permutation Test' Springer-Verlag.

Rassman, K., C. Scholotterer and D. Tautz. 1991. Isolation of simple-sequence loci for use in polymerase chain reaction base DNA fingerprinting. Electrophoresis 12:113-118.

Roslin Institute 2000. Bovine gene map. URL=

Stone, R. T., E. Casas, S. M. Cappes and J. W. Keele. 1999. Status of mapping bovine QTL at the U.S. meat animal research center. Plant-Animal Genome VII Conference, San Diego, CA:W34.

Taylor, J. F., S. K. Davis, J. O. Sanders, J. W. Turner, R. K. Miller and S. B. Smith. 1998. Identification of QTLs for growth and carcass quality in a cross between Bos indicus and Bos taurus. Plant-Animal Genome VII Conference, San Diego, CA:W19.

Weller, J. I. 1986. Maximum likelihood techniques for the mapping and analysis quantitative trait loci with the aid of genetic markers. Biometrics 42:627-640. crossref(new window)