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Effects of Fluoride Levels on Lipid Peroxidation and Antioxidant Systems of Growing/Finishing Pigs
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 Title & Authors
Effects of Fluoride Levels on Lipid Peroxidation and Antioxidant Systems of Growing/Finishing Pigs
Tao, X.; Xu, Z.R.; Han, X.Y.; Wang, Y.Z.; Zhou, L.H.;
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Malondialdehyde (MDA) and total antioxidant capacity (T-AOC) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), glutathione transferase (GST) and xanthine oxidase (XOD) activities were analyzed in serum, livers and kidneys of pigs treated with graded doses of fluoride (as NaF). Ninety-six Duroc-Landrace-Yorkshire crossbred growing pigs (48 barrows and 48 gilts, respectively), with similar initial weight 24.141.12kg, were randomly assigned to four different treatments. These treatments containing the following added F: basal control; 50 mg/kg F; 100 mg/kg F and 150 mg/kg F were randomly assigned to four pens (three barrows and three gilts) each in a completely randomized design. The results showed pigs treated with 150 mg/kg F significantly decreased average daily gain (ADG) (p<0.05) and increased feed/gain ratio (F/G) (p<0.05) compared to the controls. In the groups treated with fluoride, the contents of MDA increased, T-AOC levels and the activities of SOD, GSH-PX, CAT, GST and XOD decreased, and most of which altered significantly (p<0.05). The study therefore indicated the mechanism of excess fluoride on the impairment of soft tissues involved in lipid peroxidation and decreased the activities of some enzymes associated with free radical metabolism.
Growing/Finishing Pigs;Fluoride;Growth Performance;Lipid Peroxidation;Antioxidant Systems;
 Cited by
Effects of Oxidative Stress on Growth Performance, Nutrient Digestibilities and Activities of Antioxidative Enzymes of Weanling Pigs,Yuan, Shi-bin;Chen, Dai-wen;Zhang, Ke-ying;Yu, Bing;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 10, pp.1600-1605 crossref(new window)
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