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Effects of Modified Montmorillonite Nanocomposite on Growing/Finishing Pigs during Aflatoxicosis
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 Title & Authors
Effects of Modified Montmorillonite Nanocomposite on Growing/Finishing Pigs during Aflatoxicosis
Shi, Y.H.; Xu, Z.R.; Feng, J.L.; Xia, M.S.; Hu, C.H.;
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Experiments were conducted to determine the efficacy of modified montmorillonite nanocomposite (MMN) to reduce the toxic effects of aflatoxin (AF) in growing/finishing pigs. 96 weaned pigs were assigned to four dietary treatment groups (0 g of MMN and 0 mg of AF/kg feed, 3 g of MMN/kg feed, 0.1 mg of AF/kg feed, and 3 g of MMN plus 0.1 mg of AF/kg feed). Body weight gain (BW gain), feed/gain ratio, serum biochemical values and enzyme activities were evaluated. Compared with the control, AF alone markedly reduced BW gain and resulted in a significantly higher feed/gain ratio. There were no differences in BW gain and feed/gain ratio between 0.3% MMN or 0.3% MMN plus AF and the control. These results suggested that the deleterious effects of AF were ameliorated by MMN addition. AF intake markedly increased relative organ weights of liver, kidney, spleen and pancreas, and resulted in significant alterations of serum parameters. However, these parameters for pigs fed diets containing MMN and AF returned to normal values, indicating that MMN had the ability to recover the AF-decreased performance, organ damage and to correct aberrations in serum parameters. These findings in our study suggested that MMN can effectively modulate the toxicity of AF in growing/finishing pigs and may offer a novel approach to the preventive management of aflatoxicosis in animals.
Aflatoxin;Modified Montmorillonite Nanocomposite (MMN);Detoxification;Pigs;
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Abdel-Wahhab, M. A., S. A. Nada and H. A. Amra. 1999. Effect of developmental toxicity in rat. J. Appl. Toxicol. 19:199-204.

AOAC. 1995. Aflatoxins in corn and peanut butter. In: (Ed. P. Cunniff), Official Methods of Analysis of AOAC International. Vol. 2. Method 990. 33, AOAC International, Gaithersburg, MD, p. 18.

Arora, R. G., L. E. Appelgren and A. Bergman. 1978. Distribution of 14C-labeled aflatoxin B1 in mice. Acta Pharmacol. Toxicol. 43:273-279.

Beckman Instruments, Inc. Scientific Instruments Division, Fullerton, CA.

Bonna, R. J., R. J. Aulerich and S. J. Bursian. 1991. Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink. Arch. Environ. Contam. Toxicol. 21:441-447.

Dale, J., M. Kowalska and D. L. Cocke. 1991. Interactions of montmorillonite with organic compounds-adsorptive and catalytic properties. Chemosphere 22:769-798.

Grant, P. G. and T. D. Phillips. 1998. Isothermal adsorption of aflatoxin B1 on HSCAS clay. J. Agric. Food Chem. 46:599-605.

Grosman, M. E., M. M. Elias and E. J. Comin. 1983. Alterations in renal function induced by aflatoxin B1 in the rat. Toxicol. Appl. Pharmacol. 69:319-325.

Harvey, R. B., W. E. Huff and L. F. Kubena. 1988. Progression of aflatoxicosis in growing barrows. Am. J. Vet. Res. 49:482-487.

Harvey, R. B., L. F. Kubena and W. E. Huff. 1989a. Effects of aflatoxin, deoxynivalenol, and their combinations in the diets of growing pigs. Am. J. Vet. Res. 50:602-608.

Harvey, R. B., L. F. Kubena and T. D. Phillips. 1989b. Prevention of aflatoxicosis by addition of hydrate sodium calcium aluminosilicate to the diets of growing barrows. Am. J. Vet. Res. 50:416-420.

Harvey, R. B., L. F. Kubena and W. E. Huff. 1990. Effects of treatment of growing swine with aflatoxin and T-2 toxin. Am. J. Vet. Res. 51:1688-1693.

Harvey, R. B., L. F. Kubena and T. D. Phillips. 1991. Diminution of aflatoxin toxicity to growing lambs by dietary supplementation with hydrate sodium calcium aluminosilicate. Am. J. Vet. Res. 52:152-156.

Harvey, R. B., L. F. Kubena and M. H. Elissalde. 1994. Comparison of two hydrate sodium calcium aluminosilicate compounds to experimentally protect growing barrows from aflatoxicosis. J. Vet. Diagn. Invest. 6:88-92.

Heathcote, J. G. and J. R. Hibbert. 1978. Pathological effects. In aflatoxins: Chemical and Biological Aspects, pp. 83-111. Elsevier Scientific, Amsterdam/Oxford/New York.

Huff, W. E. and J. A. Doeer. 1981. Synergism between aflatoxin and ochratoxin A in broiler chickens. Poult. Sci. 60:550-555.

Huff, W. E., L. F. Kubena and R. B. Harvey. 1986. Progression of aflatoxicosis in broiler chichens. Poult. Sci. 65:1891-1899.

Ikegwuonu, F. L., G. N. Egbunike and G. O. Emerole. 1980. The effects of aflatoxin B1 on some testicular and kidney enzyme activity in rat. Toxicol. 17:9-16.

Ishida, H. and S. Campbell. 2000. General approach to nanocomposite preparation. Chem. Mater. 12(5):1260-1267.

Kececi, T. H., V. Kurtoglu and O. Demet. 1998. Effects of polyvinylpolypyyolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. Br. Poult. Sci. 39:452-458.

Kubena, L. F., T. D. Phillips and W. E. Huff. 1990. Diminution of aflatoxicosis in growing chickens by addition of hydrate sodium calcium aluminosilicate. Poult. Sci. 69:727-735.

Kubena, L. F., W. E. Huff and R. B. Harvey. 1991. Effects of a hydrate sodium calcium aluminosilicate on growing turkey poults during aflatoxicosis. Poult. Sci. 70:1823-1830.

Kubena, L. F., R. B. Harvey and T. D. Phillips. 1993. Effects of hydrate sodium calcium aluminosilicate on aflatoxicosis in broiler chicks. Poult. Sci. 72:651-657.

Lindemann, M. D., D. J. Blodgett and E. T. Kornegay. 1993. Potential ameliorator of aflatoxicosis in weanng/growing swine. J. Anim. Sci. 71:171-178.

Mayura, K., M. A. Abdel-Wahhab and K. S. Mckenzie. 1998. Prevention maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: potential for hidden risks. Toxicol. Sci. 41:175-182.

Mishra, H. N. and Chitrangada Das. 2003. A review on biological control and metabolism of aflatoxin. Crit. Rev. Food Sci. Nutr. 43(3): 245-264.

National Research Council. 1994. Nutrient Requirements of Swine. 4th rev. ed. National Academy Press, Washington, DC.

Ramos, A. J. and E. Hernandez. 1996. In vitro aflatoxin adsorption by means of a montmorillonite silicate. A study of adsorption isotherms. Anim. Feed Sci. Technol. 62:263-269.

Robens, J. F. and J. L. Richard. 1992. Aflatoxins in animal and human health. Rev. Environ. Contam. Toxicol. 127:69-94.

SAS Institute. 1985. SAS User’s Guide: Statistics. Version 6 Edition. SAS Institute Inc., Cary, NC.

Schell, T. C., M. D. Lindemann and E. T. Kornegay. 1993a. Effectiveness of different types of clay for reducing the detrimental effects of aflatoxin-contaminated diets on performance and serum profiles of weaning pigs. J. Anim. Sci. 71:1223-1231.

Schell, T. C., M. D. Lindemann and E. T. Kornegay. 1993b. Effects of feeding aflatoxin-contaminated diets with and without clay to weaning and growing pigs on performance, liver function, and mineral metabolism. J. Anim. Sci. 71:1209-1218.

Smela, M. E., S. S. Currier and E. A. Bailey. 2001. The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis. Carcinogenesis. 22(4):535-545.

Tung, H. T., R. D. Wyatt and P. Thaxton. 1975. Concentrations of serum proteins during aflatoxicosis. Toxicol. Appl. Pharm. 34:320-326.

Vaia, R. A. and E. P. Giannelis. 1997a. Lattice model of polymer melt intercalation in organically-modified layered silicates. Macromolecules. 30:7990-7999.

Vaia, R. A., B. B. Sauer and O. K. Tse. 1997b. Relaxations of confined chains in polymer nanocomposites glass transition properties of poly intercalated in montmorillonite. Polym. Sci. PartB. Polym. Phys. 35:59-67.

Yu, S. 1977. Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA-synthesis. J. Biol. Chem. 252:3245-3251.