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Effects of Olaquindox and Cyadox on Immunity of Piglets Orally Inoculated with Escherichia coli
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 Title & Authors
Effects of Olaquindox and Cyadox on Immunity of Piglets Orally Inoculated with Escherichia coli
Ding, Mingxing; Yuan, Zonghui; Wang, Yulian; Zhu, Huiling; Fan, Shengxian;
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A 23 factorial arrangement of treatments was used to determine the effects of olaquindox and cyadox on immune response of LandraceLarge-White geld piglets that had been orally given 10 CFU of Escherichia coli (E. coli, O:K). Factors included (1) E. coli inoculation or control, and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. E. coli inoculums were orally administered 7 days after the diets were supplemented with olaquindox and cyadox. The effects of the two antimicrobials were assessed in terms of: (1) average daily gain (ADG), (2) systemic immune response (the number of white blood cells and lymphocytes, leukocyte bactericidal capacity, lymphocyte proliferation response to PHA, immunoglobulin concentrations, and total serous hemolytic complement activity), and (3) intestinal mucosal immunity including the number of intraepithelial lymphocytes (IELs) and immunoglobulin A secreting cells (ASCs) in the intestinal lamina propria. E. coli inoculation reduced ADG (p<0.05) during the period of d 0 to d 14 after the challenge while the antimicrobial supplementations improved ADG (p<0.01) during the experiment. ADG in cyadox-supplemented pigs was higher (p<0.05) than that in olaquindox-supplemented pigs. The antimicrobials decreased IEL and ASC counts in the jejunum and ileum (p<0.01) while E. coli inoculation caused them to increase (p<0.01). Jejunal ASCs in the cyadox-supplemented pigs were lower (p<0.05) than those in the olaquindox-supplemented. E. coli elicited increase (p<0.05) in white blood cell counts, leukocyte bactericidal capacity, lymphocyte proliferation rate, serous IgA concentrations, and serous hemolytic complement activity. The antimicrobials decreased the measured systemic immune parameters, but not significantly (p>0.05). The data suggest that olaquindox and cyadox suppress E. coli-induced immune activation, especially intestinal mucosal immune activation, which may be involved in the observed growth promotion.
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아세아태평양축산학회지, 2007. vol.20. 3, pp.405-411 crossref(new window)
Ahren, C., M. Jertborn and A. M. Svennerholm. 1998. Intestinal immune responses to an inactivated oral enterotoxigenic E. coli vaccine and associated immunoglobulin A responses in blood. Infect. Immun. 66 (7):3311-3326.

Blecha, F., D. S. Pollmann and D. A. Nichols. 1983. Weaning pigs at an early age decreases cellular immunity. J. Anim. Sci. 56:396.

Broz, J. and B. Sevcik. 1979. Determination of the optimum effective dose of the stimulator cyadox in piglet fattening. Biol. Chem. Zivocisne Vyzoby Vet. 15(4):319-325.

Corpet, D. E. 1999. Mechanism of antimicrobial growth promoters used in animal feed. Comptes Rendus de l’ Academie d’ Agriculture de France. 85(7):197-205.

Chu, R. M., R. D. Glock, R. F. Ross and D. P. Cox. 1979. Lymphoid tissues of the small intestine of swine from birth to one month of age. Am. J. Vet. Res. 40:17139.

Giurgea, R., I. Suteu and D. Ioaniciu. 1976. The effect of Mecadox on the immune response and on various chicken lymphatic organs. Arch. Exp. Veterinar. Med. 30(2):293-298.

Grunfeld, C. and K. R. Feingold. 1992. Tumor necrosis factor, Interleukin and interferon induced changes in lipid metabolism as part of host defense. Proc. Soc. Biol. Med. 200:224.

Heugten, E. V., J. W. Spears and M. T. Coffey. 1994. The effect of dietary protein on performance and immune response in weanling pigs subjected to an inflammatory challenge. J. Anim. Sci. 72:2661-2669.

Heugten, E. V. and J. W. Spears. 1997. Immune response and growth of stressed weanling pigs fed diets supplemented with organic or inorganic forms of chromium. J. Anim. Sci. 75:409-416.

Jones, P. H., J. M. Roe and B. G. Miller. 2001. Effects of stressors on immune parameters and on the fecal shedding of enterotoxigenic E. coli in piglets following experimental inoculation. Res. Vet. Sci. 70:9-17.

Liping, Z. and C. Xueqing. 2000. Mianyixue Changyong Shiyanfangfa. Beijin: Renming Junyi Pres. 120-186.

Mestecky, J. and J. R. Meghee. 1987. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40:153-245.

Reyero, C. and W. Stockl. 1977. Isolation of porcine colostral immunoglobulins and preparation of monospecific anti-$\gamma$, anti-$\alpha$, and anti-$\mu$ chain antibodies using agarose-linked immunosorbents. J. Immunol. Methods. 15:211-221.

Roberts, E. S., E. van Heugten, J. W. Spears, P. A. Routh, K. L. Lloyd and G. W. Almond. 2004. Effects of dietary zinc on performance and immune response of growing pigs inoculated with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Asian-Aust. J. Anim. Sci. 17(10):1438-1446.

Sauber, T. E., T. S. Stahly and B. J. Nonnecke. 1999. Effect of level of chronic immune system activation on the lactational performance of sows. J. Anim. Sci. 77(8):1985-1993.

Sarmiento, J. I., T. A. Casey and H. W. Moon. 1988a. Postweaning diarrhea in swine: Experimental model of enterotoxigenic E. coli infection. Am. J. Vet. Res. 49(7):1154-1159.

Sarmiento, J. I. and H. W. Moon. 1988b. Postweaning diarrhea in swine: Effects of oxytetracycline on enterotoxigenic E. coli infection. Am. J. Vet. Res. 149(7):1160-1163.

Shengxian, F., Y. Zonghui, W. Daju, K. Ke, C. Pin and M. Jingzhong. 2000. Antibacterial activity in vitro of cyadox. J. Huazhong Agricultural University 19(1):51-54.

Spierenburg, T. J., L. P. Jager, G. J. Graaf and A. J. Baaea. 1988. Concentration profiles of carbadox, olaquindox and cyadox along the gut of young pigs. Veterinary pharmacology, toxicology and therapy in food producing animals. 4th congress of European Association for veterinary pharmacology and toxicology. Hungary. August 28-September 2. p. 30

Tingshui, C. and G. Yuming. 2004. Effects of Salmonella typhymurium lipopolysaccharide challenge on the performance, immune responses and zinc metabolism of laying hens supplemented with two zinc sources. Asian-Aust. J. Amin. Sci. 17(12):1717-1724.

Uovsova, R. and J. Urbunck. 1983. Effect of various synthetic growth promoters on the nutritive value of compound feed COS2 and A1. Bio. Chem. Zivocisne Vyroby Vet. 19(1):5-14.

Visek, W. J. 1978. The mode of growth promotion by antibiotics. J. Anim. Sci. 46:1447-1469.

Yen, J. T. and W. G. Pond. 1987. Effect of dietary supplementation with vitamin C or carbadox on weanling pigs subjected to crowding stress. J. Anim. Sci. 64(6):1672-1681.