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Association of Polymorphisms in the Bovine Leptin Gene with Ultrasound Measurements for Improving in Korean Cattle
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 Title & Authors
Association of Polymorphisms in the Bovine Leptin Gene with Ultrasound Measurements for Improving in Korean Cattle
Kong, H.S.; Oh, J.D.; Lee, S.G.; Hong, Y.S.; Song, W.I.; Lee, S.J.; Kim, H.C.; Yoo, B.H.; Lee, H.K.; Jeon, G.J.;
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The identification method that inflects real time ultrasound (RUT) and the potential application of marker assisted selection (MAS) for improvement of a cow population of Hanwoo (Korean Native cattle) was studied. The averages of RUT longissimus muscle area, RUT fat thickness, and RUT marbling score scanned at the 13th rib were 55.78 , 3.70 mm and 3.83 scores, respectively. We investigated the effects of the two SNPs (Kpn2 I and Msp I) in the leptin gene on carcass traits for Hanwoo cows by using ultrasound measurements. Genotype CC of the Kpn2 I had a significantly higher effect on back fat thickness (4.23 mm) and longissimus muscle area (57.57 ) than genotype TT (3.14 mm, 53.93 , respectively, p<0.05). Genotype AA of the Msp I had a significantly higher effect only on marbling score (5.37) than genotype AB (3.57, p<0.05) and BB (3.37, p<0.05). Significant effects of SNPs in the leptin gene were found for the ultrasound measures of body composition in live cattle.
Korean Native Cattle;Leptin Gene;Improvement of Cow;Real Time Ultrasound (RTU);
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Baik, M. G. and K. S. Kim. 2004. Production of Leptin in E. coli and Its Effect on Glucose and Acetate Transport and Expression of Uncoupling Protein-2 Gene in Adipose Tissues of Korean Cattle (Hanwoo). Asian-Aust. J. Anim. Sci. 17(8):1062-1069 crossref(new window)

Barb, C. R., X. Yan, M. J. Azain, R. R. Kraeling, G. B. Rampacek and T. G. Ramsay. 1998. Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Domest. Anim. Endocrinol. 15:77-86 crossref(new window)

Blache, D., R. L. Tellam, L. M. Chagas, M. A. Blackberry, P. E. Vercoe and G. B. Martin. 2000. Level of nutrition affects leptin concentrations in plasma and cerebrospinaluid in sheep. J. Endocrinol. 165:625-637 crossref(new window)

Block, S. S., W .R. Butler, R. A. Ehrhardt, A. W. Bell, M. E. Van- Amburgh and Y. R. Boisclair. 2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171(2):339-348 crossref(new window)

Buchanan, F. C., C. J. Fitzsimmons, A. G. Van Kessel, T. D. Thue, D. C. Winkelman-Sim and S. M. Sshmutz. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Sel. Evol. 34:105- 116 crossref(new window)

Considine, R. V. 1997. Weight regulation, leptin and growth hormone. Horm. Res. 48(Suppl. 5):116-121 crossref(new window)

Delavaud, C., F. Bocquier, Y. Chilliard, D. H. Keisler, A. Gertler and G. Kann. 2000. Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RNA in sheep. J. Endocrinol. 165:519-526 crossref(new window)

Devitt, C. J. B. and J. W. Wilton. 2001. Genetic correlation estimates between ultrasound measurements on yearling bulls and carcass measurement on finished steers. J. Anim. Sci. 79:2790-2797

Dyer, C. J., J. M. Simmons, R. L. Matteri and D. H. Keisler. 1997. Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes. Domest. Anim. Endocrinol. 14:119-128 crossref(new window)

Ehrhardt, R. A., R. M. Slepetis, J. Siegal-Willott, M. E. Van- Amburgh, A. W. Bell and Y. R. Boisclair. 2000. Development of a specific radio immunoas say to measure physiological changes of circulating leptin in cattle and sheep. J. Endocrinol. 166:519-528 crossref(new window)

Fitzsimmons, C. J., S. M. Schmutz, R. D. Bergen and J. J. McKinnon. 1998. A potential association between the BM 1,500 microsatellite and fat deposition in beef cattle. Mamm Genome. 1998 Jun;9(6):432-434 crossref(new window)

Fruhbeck, G., S. A. Jebb and A. M. Prentice. 1998. Leptin: Physiology and pathophysiology. Clin. Physiol. 18:399-419 crossref(new window)

Haegeman, A., A. Van-Zeveren and L. J. Peelman. 2000. New mutation in exon 2 of the bovine leptin gene. Anim. Genet. 2000 Feb;31(1):79 crossref(new window)

Hager, J., K. Clement, S. Francke, C. Dina, J. Raison, N. Lahlou, N. Rich, V. Pelloux, A. Basdevant, B. Guy-Grand, M. North and P. Froguel. 1998. A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels. Int. J. Obes. Relat. Metab. Disord. 22(3):200-205 crossref(new window)

Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley and J. M. Friedman. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Sci. 269:543-546 crossref(new window)

Henry, B. A., J. W. Goding, W. S. Alexander, A. J. Tilbrook, B. J. Canny, F. Dunshea, A. Rao, A. Mansell and I. J. Clarke. 1999. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinol. 140:1175-1182 crossref(new window)

Herring, W. O., L. A. Kriese, J. K. Bertrand and J. Crouch. 1998. Comparison of four real-time ultrasound systems that predict intramuscular fat in beef cattle. J. Anim. Sci. 76:364-370

Houseknecht, K. L., C. A. Baile, R. L. Matteri and M. C. Spurlock. 1998. The Biology of leptin: A review. J. Anim. Sci. 76:1405-1420

Houseknecht, K. L. and C. P. Portocarrero. 1998. Leptin and its receptors: regulators of whole-body energy homeostasis. Domest. Anim. Endocrinol. 15(6):457-475 crossref(new window)

Ji, S., G. M. Willis, R. R. Scott and M. E. Spurlock. 1998. Partial cloning and expression of the bovine leptin gene. Anim. Biotechnol. 9:1-14 crossref(new window)

Kadokawa, H., D. Blache, Y. Yamada and G. B. Martin. 2001. Relationships between changes in plasma concentrations of leptin before and after parturition and the timing of first postpartum ovulation in high-producing Holstein dairy cows. Reprod. Fertil 12(7-8):405-411

Kim, H. B. 1997. Polymorphism study of obese gene by PCRRFLP for development of DNA marker related to meat quality in Hanwoo (Bos taurus koreanae). A master's thesis. Seoul Univ. Korea

Kim, H. C., D. H. Lee, S. B. Choi and G. J. Jeon. 2003. Relationship between ultrasonic and carcass measures for meat qualities in Hanwoo steers. J. Anim. Sci. Technol. (Kor). 45:183-190 crossref(new window)

Konfortov, B. A., V. E. Licence and J. R. Miller. 1999. Resequencing DNA from a diverse panel of cattle reveals a high level of polymorphism in both intron and exon. Mamm. Genome. 10:1142-1145 crossref(new window)

Lein, S., H. Sundvold, H. Klungland and D. I. Vage. 1997. Two novel polymorphisms in the bovine obesity gene (OBS). Anim. Genet. 28:245

Mendiola, J., M. Janzen, M. Cruz and C. F. Louis. 1997. Cloning and tissue distribution of leptin mRNA in the pig. Anim. Biotechnol. 8:227-236 crossref(new window)

Miller, S. A., D. D. Dykes and H. F. Polesky. 1988. A simple salting out procedure for extracting DNA from human uncleated cells. Nucleic Acids Res. 16:1215 crossref(new window)

Moser, D. W., J. K. Bertrand, I. Misztal, L. A. Kriese and L. L. Benyshek. 1998. Genetic parameter estimates for carcass and yearling ultrasound measurements in Brangus cattle. J. Anim. Sci. 76:2542-2548 crossref(new window)

Ohshiro, Y., K. Ueda, M. Nishi, M. Ishigame, H. Wakasaki, H. Kawashima, H. Furuta, H. Sasaki, T. Sanke, N. Takasu and K. Nanjo. 2000. A polymorphic marker in the leptin gene associated with Japanese morbid obesity. J. Mol. Med. 78(9):516-20 crossref(new window)

Orbak, Z., S. Darcan, M. Coker and D. Goksen. 2001. Maternal and fetal serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3), leptin levels and early postnatal growth in infants born asymmetrically small for gestational age. J. Pediatr Endocrinol. Metab. 14(8):1119-1127

Prins, J. B. and S. O'Rahilly. 1997. Regulation of adipose cell number in man. Clin. Sci. (Lond.). 92:3-11 crossref(new window)

Pomp, D., T. Zou, A. C. Clutter and W. Barendse. 1997.Mapping of leptin to bovine chromosome 4 by linkage analysis of a PCR-based polymorphism. J. Anim. Sci. 75:1427

Raver, N., M. Taouis, S. Dridi, M. Derouet, J. Simon, B. Robinzon, J. Djiane and A. Gertler. 1998. Large-scale preparation of biologically active recombinant chicken obese protein (leptin). Protein Expression and Purification 14:403-408 crossref(new window)

Reverter, A., D. J. Johnston, H. U. Graser, M. L. Wolcott and W. H. Upton. 2000. Genetic analyses of live-animal ultrasound and abattoir carcass traits in Australian Angus and Hereford cattle. J. Anim. Sci. 78:1786-1795

Santos-Alvarez, J., R. Goberna and V. Sanchez-Margalet. 1999. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol. 25:194(1):6-11

Schenkel, F. S., S. P. Miller, X. Ye, S. S. Moore, J. D. Nkrumah, C. Li, J. Yu, I. B. Mandell, J. W. Wilton and J. L. Williams. 2005. Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. J. Anim. Sci. 83(9):2009-2020

Wilkins, R. J. and H. W. Davey. 1997. A polymorphic microsatellite in the bovine leptin gene. Anim. Genet. 28:376 crossref(new window)

Wilson, D. E., G. H. Rouse, C. L. Hays, V. R. Amin and A. Hassen. 1999. Carcass expected progeny differences using real-time ultrasound measures from yearling Angus bulls. J. Anim. Sci. 77(Suppl. 1) 143(Abstr.)

Yoon, D. H., B. H. Cho, B. L. Park, Y. H. Choi, H. S. Cheong, H. K. Lee, E. R. Chung, I. C. Cheong and H. D. Shin. 2005. Highly Polymorphic Bovine Leptin Gene. Asian-Aust. J. Anim. Sci. 18(11):1548-1552 crossref(new window)

Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.) 372:425-432 crossref(new window)