JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
Wang, Ying; Li, Hui; Zhang, YuanDan; Gu, ZhiLiang; Li, ZhiHui; Wang, QiGui;
  PDF(new window)
 Abstract
Leptin receptor (OBR) is a member of the class I cytokine receptor family. It signals mainly via the JAK/STAT pathway and plays an important role in regulating body energy storage and metabolism. This study was designed to investigate the effects of the OBR gene on chicken growth and body composition. Broiler lines selected divergently for or against abdominal fat were used. Primers for the exon9-region in the OBR gene were designed using chicken genomic sequences from the public genome domain. A C/A single nucleotide polymorphism (SNP) was found and its three genotypes (AA, AB and BB) were identified in this population. The results showed that the OBR polymorphism was associated with fatness traits, such as abdominal fat weight and abdominal fat percentage. This research suggests that OBR or a linked gene has effect on fat deposition in the chicken.
 Keywords
Chicken;OBR Gene;Single Nucleotide Polymorphism (SNP);Abdominal Fat;
 Language
English
 Cited by
1.
Identification of Single Nucleotide Polymorphism of H-FABP Gene and Its Association with Fatness Traits in Chickens,;;;;;;

아세아태평양축산학회지, 2007. vol.20. 12, pp.1812-1819 crossref(new window)
2.
Estimation of Interaction Effects among Nucleotide Sequence Variants in Animal Genomes,;;

아세아태평양축산학회지, 2009. vol.22. 1, pp.124-130 crossref(new window)
1.
Leptin in farm animals: where are we and where can we go?, animal, 2011, 5, 02, 246  crossref(new windwow)
2.
Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits, Biochemical Genetics, 2008, 46, 11-12, 828  crossref(new windwow)
3.
Effect of chicken leptin recptor short hairpin RNA on expression of JAK2 , STAT3 , SOCS3 and CPT1 genes in chicken preadipocytes, Animal Science Journal, 2017, 88, 3, 559  crossref(new windwow)
4.
Recent Progress in Avian Leptin Research, The Journal of Poultry Science, 2014, 51, 4, 343  crossref(new windwow)
5.
Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens, Poultry Science, 2014, 93, 8, 1910  crossref(new windwow)
 References
1.
Boldman, K. and D. V. Vleck. 2002. MTDFREML manual, United States Department of Agriculture USA

2.
Chen, C. C., T. Chang and H. Y. Su. 2004. Characterization of porcine leptin receptor polymorphisms and their association with reproduction and production traits. Anim. Biotechnol. 15 (1): 89-102 crossref(new window)

3.
Dunn, I. C., T. Boswell, M. Friedman-Einat, Y. Eshdat, D. W. Burt and I. R. Paton. 2000. Mapping of the leptin receptor gene (lepr) to chicken chromosome 8. Anim. Genet. 31(4): 290-295

4.
Fei, H., H. J. Okano, C. Li, G. H. Lee, C. Zhao, R. Darnell and J. M. Friedman. 1997. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. 94(13): 7001-7005

5.
Gu, Z. L., J. G. Zhao, H. Li, H. Meng, Q. Q. Wang, Q. H. Wang, and D. H. Zhu. 2002 Single Nucleotide Polymorphism Analysis in Chicken Leptin Receptor Exon9. Hereditas (Beijing) 24 (3): 259-262

6.
Horev, G., P. Einat, T. Aharoni, Y. Eshdat and M. Friedman-Einat. 2000. Molecular cloning and properties of the chicken leptinreceptor (CLEPR) gene. Mol. Cell Endocrnol. 162(1-2):95-106 crossref(new window)

7.
Houseknecht, K. L. and C. P. Portacarrero. 1998. Leptin and its receptors: regulators of whole-body energy homeostasis. Domest. Anim. Endocrinol. 15(6): 457-475 crossref(new window)

8.
Li, H., N. Deeb, H. Zhou, A. D. Mitchell, C. M. Ashwell and S. J. Lamont. 2003. Chicken quantitative trait loci for growth and body composition associated with transforming growth factor- $\beta$ genes. Poult. Sci. 82(3): 347-356

9.
Li, C. Y. and H. Li. 2006. Association of MC4R Gene Polymorphisms with Growth and Body Composition Traits in Chicken. Asian-Aust. J. Anim. Sci. 19(6):763-768

10.
Martin, A., E. A. Dunnington, W. B. Gross, W. E. Briles, R. W. Briles and P. B. Siegel. 1990. Production traits and alloantigen systems in lines of chickens selected for high or low antibody responses to sheep erythrocytes. Poult. Sci. 69(6): 871-878

11.
Meng, H., J. G. Zhao, Z. H. Li and H. Li. 2005. Single Nucleotide Polymorphisms on Peroxisome Proliferator-activated Receptor Genes Associated with Fatness Traits in Chicken. Asian-Aust. J. Anim. Sci. 18(9):1221-1225

12.
Ohkubo, T., M. Tanaka and K. Nakashima. 2000. Structure and tissue distribution of chicken leptin receptor (cOB-R) mRNA. Biochim. Biophys. Acta. 1491(1-3):303-308

13.
Pinard-van, D. L. H. M., P. B. Siegel and S. J. Lamont. 1998. Lessons from selection experiments on immune response in the chicken. Poult. Avi. Bio. Rev. 9: 125-141

14.
Quinton, N. D., A. J. Lee, R. J. Ross, R. Eastell and A. I. Blakemore. 2001. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum. Genet. 108 (3):233-236 crossref(new window)

15.
Rothschild, M. F. and M. Soller. 1997. Candidate gene analysis to detect genes controlling traits of economic importance in domestic livestock. Probe Newslett. Agric. Genom. 8:13-20

16.
SAS Institute Inc. 2002. JMP User's Guide. Cary, NC: SAS Institute Inc

17.
Tartaglia, L. A. 1997. The leptin receptor. J. Biol. Chem. 272(10): 6093-6097

18.
Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark and J. Deeds. 1995. Identification and expression cloning of a leptin receptor, OB-R Cell 83(7):1263-1271 crossref(new window)

19.
Wang, W. J., K. Ouyang, J. Ouyang, H. Li, S. Lin and H. Sun. 2004. Polymorphism of Insulin-like Growth Factor I Gene in Six Chicken Breeds and Its Relationship with Growth Traits. Asian-Aust. J. Anim. Sci. 17(3):301-305

20.
Zhang, Y., R. Proenca, M. Maffel, M. Barone, L. Leopold and J. M. Frideman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 374(6251):425-431 crossref(new window)