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Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
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 Title & Authors
Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
Wang, Ying; Li, Hui; Zhang, YuanDan; Gu, ZhiLiang; Li, ZhiHui; Wang, QiGui;
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Leptin receptor (OBR) is a member of the class I cytokine receptor family. It signals mainly via the JAK/STAT pathway and plays an important role in regulating body energy storage and metabolism. This study was designed to investigate the effects of the OBR gene on chicken growth and body composition. Broiler lines selected divergently for or against abdominal fat were used. Primers for the exon9-region in the OBR gene were designed using chicken genomic sequences from the public genome domain. A C/A single nucleotide polymorphism (SNP) was found and its three genotypes (AA, AB and BB) were identified in this population. The results showed that the OBR polymorphism was associated with fatness traits, such as abdominal fat weight and abdominal fat percentage. This research suggests that OBR or a linked gene has effect on fat deposition in the chicken.
Chicken;OBR Gene;Single Nucleotide Polymorphism (SNP);Abdominal Fat;
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