Advanced SearchSearch Tips
Association of Leptin Polymorphism with Production, Reproduction and Plasma Glucose Level in Iranian Holstein Cows
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Association of Leptin Polymorphism with Production, Reproduction and Plasma Glucose Level in Iranian Holstein Cows
Moussavi, A. Heravi; Ahouei, M.; Nassiry, M.R.; Javadmanesh, A.;
  PDF(new window)
The objective of this study was to evaluate the association of genetic differences in the bovine leptin gene and milk yield, reproduction, body condition score (BCS), and plasma glucose level in Iranian Holstein cows. In total, two hundred and thirty eight cows were used and genotyped for a restricted fragment length polymorphism at the leptin gene locus. Two genotypes, AA and AB, have been distinguished which have the frequencies of 0.89 and 0.11, respectively. The genotypes were distributed according to the Hardy - Weinberg equilibrium ( = 0.733). During the first 12 wk of lactation, milk yield and composition, live weight, BCS and plasma glucose were measured in 50 cows. Data were analyzed based on a repeated measures ANOVA. During this period, milk yield and composition, live weight, BCS and plasma glucose level were similar among the genotypes. The first cumulative 60-d milk yield, 305-d milk yield, days to first breeding, days open and days from first breeding to conception using previous lactation records were also analyzed using Standard Least Square within mixed models. Fixed effects were year, season, parity and age at calving, and sire. For the reproductive traits the cumulative first 60-d milk yield was also added to the model. Animal was fitted as a random effect. A significant association was detected between the RFLP-AB genotype and 305-d milk yield (p<0.05). The first 60-d cumulative milk yield was similar for the two genotypes (p = 0.21) and tended to be higher in the heterozygous cows. The heterozygous genotypes at the above mentioned locus had a trend to better reproductive performance than the homozygous. The results demonstrate that the RFLP B-allele can yield a higher 305-d milk production with a trend to better reproductive performance.
Holstein Cows;Leptin Polymorphism;Milk Yield;Reproductive Performance;
 Cited by
Characterization of Leptin Levels in Gestating Callipyge Ewes,Fleming-Waddell, J.N.;Keisler, D.H.;Jackson, S.P.;Blanton, J.R. Jr.;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 1, pp.41-44 crossref(new window)
번식장애 한우의 렙틴 및 인슐린 농도 변화,최창용;강다원;

한국수정란이식학회지, 2008. vol.23. 3, pp.189-195
Cloning and Expression of the Duck Leptin Gene and the Effect of Leptin on Food Intake and Fatty Deposition in Mice,Dai, Han Chuan;Long, Liang Qi;Zhang, Xiao Wei;Zhang, Wei Min;Wu, Xiao Xiong;

Asian-Australasian Journal of Animal Sciences, 2007. vol.20. 6, pp.850-855 crossref(new window)
Almeida, S. E. M., E. A. Almeida, J. C. F. Moraes and T. A. Weimer. 2003. Molecular markers in the LEP gene and reproductive performance of beef cattle. J. Anim. Breeding Genet. 120:106-113 crossref(new window)

Block, S. S., W. R. Butler, R. A. Ehrhardt, A. W. Bell, M. E. Van Amburgh and Y. R. Boisclair. 2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171:339-348 crossref(new window)

Buchanan, F. C., A. G. Van Kessel, C. Waldner, D. A. Christensen, B. Laarveld and S. M. Schmutz. 2003. Hot topic: an association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 86:3164-3166

Chen, C. C., T. Chang and H. Y. Su. 2004. Characterization of porcine leptin receptor polymorphisms and their association with reproduction and production traits. Anim. Biotechnol. 15:89-102 crossref(new window)

Fruhbeck, G., S. A. Jebb and A. M. Prentice. 1998. Leptin: physiology and pathophysiology. Clin. Physiol. 18:399-419 crossref(new window)

Hossner, K. L. 1998. Cellular, molecular and physiological aspects of leptin: Potential application in animal production. Can. J. Anim. Sci. 78:463-472

Houseknecht, K. L., C. A. Baile, R. L. Matteri and M. E. Spurlock. 1998. The biology of leptin: a review. J. Anim. Sci. 76:1405- 1420

Kadokawa, H., D. Blache, Y. Yamada and G. B. Martin. 2000. Relationships between changes in plasma concentrations of leptin before and after parturition and the timing of first postpartum ovulation in high-producing Holstein dairy cows. Reprod. Fertil. Dev. 12:405-411 crossref(new window)

Kim, K. S. and M. G. Baik. 2004. Production of leptin in E. coli and its effect on glucose and acetate transport and expression of uncoupling protein-2 gene in adipose tissues of Korean cattle (Hanwoo). Asian-Aust. J. Anim. Sci. 17:1062-1068

Lein, S., H. Sundvold, H. Klungland and D. I. Vage. 1997. Two novel polymorphisms in the bovine obesity gene (OBS). Anim. Genet. 28:245

Leury, B. J., L. H. Baumgard, S. S. Block, N. Segoale, R. A. Ehrhardt, R. P. Rhoads, D. E. Bauman, A. W. Bell and Y. R. Boisclair. 2003. Effect of Insulin and Growth Hormone on Plasma Leptin in the Periparturient Dairy Cow. Am. J. Physiol Regul. Integr. Comp. Physiol. 285:1107-1115

Liefers, S. C., M. F. te Pas, R. F. Veerkamp, Y. Chilliard, C. Delavaud, R. Gerritsen and L. T. van der. 2003. Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mamm. Genome. 14:657-663 crossref(new window)

Liefers, S. C., M. F. te Pas, R. F. Veerkamp and L. T. van der. 2002. Associations between leptin gene polymorphisms and production, live weight, energy balance, feed intake and fertility in Holstein heifers. J. Dairy Sci. 85:1633-1638

Lindersson, M., L. Andersson-Eklund, D. J. De Koning, A. Lunden, A. Maki-Tanila and L. Andersson. 1998. Mapping of Serum Amylase-1 and Quantitative Trait Loci for Milk Production Traits to Cattle Chromosome. J. Dairy Sci. 81:1454-1461

Mackle, T. R., A. M. Bryant, S. F. Petch, J. P. Hill and M. J. Auldist. 1999. Nutritional Influences on the Composition of Milk from Cows of Different Protein Phenotypes in New Zealand. J. Dairy Sci. 82:172-180

Madeja, Z., T. Adamowicz, A. Chmurzynska, T. Jankowski, J. Melonek, M. Switonski and T. Strabel. 2004. Short Communication: Effect of Leptin Gene Polymorphisms on Breeding Value for Milk Production Traits. J. Dairy Sci. 87:3925-3927

Magni, P., M. Motta and L. Martini. 2000. Leptin: a possible link between food intake, energy expenditure, and reproductive function. Regulatory Peptides 92:51-56 crossref(new window)

Nagatani, S., Y. Zeng, D. H. Keisler, D. L. Foster and C. A. Jaffe. 2000. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinol. 141:3965- 3975 crossref(new window)

Nei, M. 1978. Estimation of average heterozygosity and genetic distance from a small number of individuals. Genetics 89:583- 590

Pomp, D., T. Zou, A. C. Clutter and W. Barendse. 1997. Rapid communication: mapping of leptin to bovine chromosome 4 by linkage analysis of a PCR-based polymorphism. J. Anim. Sci. 75:1427

Pryce, J. E., M. P. Coffey and S. Brotherstone. 2000. The genetic relationship between calving interval, body condition score and linear type and management traits in registered Holsteins. J. Dairy Sci. 83:2664-2671

Stone, R. T., S. M. Kappes and C. W. Beattie. 1996. The bovine homolog of the obese gene maps to chromosome-4. Mamm. Genome. 7:399-400 crossref(new window)

Thomas, M. G., R. M. Enns, D. M. Hallford, D. H. Keisler, B. S. Obeidat, C. D. Morrison, J. A. Hernandez, W. D. Bryant, R. Flores, R. Lopez and L. Narro. 2002. Relationships of metabolic hormones and serum glucose to growth and reproductive development in performance-tested Angus, Brangus, and Brahman bulls. J. Anim. Sci. 80:757-767

Veerkamp, R. F., J. K. Oldenbroek, H. J. Van Der Gaast and J. H. J. Werf. 2000. Genetic Correlation Between Days Until Start of Luteal Activity and Milk Yield, Energy Balance, and Live Weights. J. Dairy Sci. 83:577-583

Vega, R. A., H. Hidari, H. Kuwayama, M. Suzuki and D. D. Manalo. 2004a. The relationships of plasma leptin, backfat thickness and TDN intake across finishing stage of Holstein steers. Asian-Aust. J. Anim. Sci. 17:330-336

Vega, R. A., H. Hidari, N. Matsunaga, H. Kuwayama, D. D. Manalo1, H. G. Lee and H. Hata. 2004b. Plasma Leptin and Performance of Purebred and Backcrossed Hereford throughout Grazing and Feedlot Fattening. Asian-Aust. J. Anim. Sci. 17:954-959

Wilkins, R. J. and H. W. Davey. 1997. A polymorphic microsatellite in the bovine leptin gene. Anim. Genet. 28:376